Results 11 to 20 of about 1,227,223 (348)
Disease modeling and drug screening using human airway organoids: a systematic review [PDF]
Organoid, 2021 Increasing levels of fine environmental dust particles due to industrialization and emerging respiratory illnesses, such as coronavirus disease 2019, pose serious threats to human life.
Do Hyun Kim, Sung Won Kim
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Frontiers in Pharmacology, 2021 Huntington’s disease (HD) is a life-threatening neurodegenerative disorder. Altered levels and functions of the purinergic ionotropic P2X7 receptors (P2X7Rs) have been found in animal and cellular models of HD, suggesting their possible role in the ...
Alberto Martire +5 more
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Advances in preclinical evaluation of experimental antibody-drug conjugates
Cancer Drug Resistance, 2021 The ability to chemically modify monoclonal antibodies with the attachment of specific functional groups has opened up an enormous range of possibilities for the targeted treatment and diagnosis of cancer in the clinic. As the number of such antibody-based drug candidates has increased, so too has the need for more stringent and robust preclinical ...
Lyons, Scott K +2 more
openaire +4 more sources
Food and Agricultural Immunology, 2021 Emerging evidence indicates that blood–retinal barrier (BRB) damage is the main cause of diabetic retinopathy (DR), and the downregulation of tight proteins (TJs) located between endothelial cells and the activation of NLRP3 inflammasome-mediated ...
Jing Wei +8 more
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Application of Genomics in Preclinical Drug Safety Evaluation [PDF]
Basic & Clinical Pharmacology & Toxicology, 2006 Abstract: Understanding the response of biological systems to xenobiotics is fundamental to the evaluation of drug safety. Toxicologists have traditionally gathered pathological, morphological, chemical and biochemical information from in vivo studies of preclinical species in order to assess drug safety and to determine how new drugs can be safely ...
Michael K. McMillian +2 more
openaire +3 more sources
Animal models of chemotherapy-induced cognitive decline in preclinical drug development
Psychopharmacology, 2021 Chemotherapy-induced cognitive impairment (CICI), chemobrain, and chemofog are the common terms for mental dysfunction in a cancer patient/survivor under the influence of chemotherapeutics.
Jeena John +4 more
semanticscholar +1 more source
P046: Preclinical evaluation of novel repurposed drug combinations in Hodgkin lymphoma
HemaSphere, 2022 Mia Lohmann +10 more
doaj +2 more sources
Scientific Reports, 2021 Nonalcoholic fatty liver disease (NAFLD) is the most common liver disease and strongly correlates with the growing incidence of obesity and type II diabetes.
Victoria L. Slaughter +10 more
semanticscholar +1 more source
Cancer Medicine, 2023 Background Anti‐angiogenic therapy with bevacizumab (BEV), an anti‐VEGF antibody, plays a critical role in the treatment of ovarian cancer. However, despite an encouraging initial response, most tumors become resistant to BEV over time, and a new ...
Tianyue Zhai +6 more
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Frontiers in Pharmacology, 2022 Many medicinal plants species from European -such as Artemisia absinthium, Equisetum arvense, Lamium album, Malva sylvestris, Morus nigra, Passiflora incarnata, Frangula purshiana, and Salix alba- as well as Latin American traditions -such as Libidibia ...
Andre Luis Dias Araujo Mazzari +13 more
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