Results 11 to 20 of about 171,263 (267)

IC50: an unsuitable measure for large-sized prostate cancer spheroids in drug sensitivity evaluation

Biomolecules & Biomedicine, 2022
Preclinical models of tumors have the potential to become valuable tools for commercial drug research and development, and 3D culture systems are gaining traction in this area, particularly in prostate cancer (PCa) research.
Yipeng Xu, Gabriela Pachnikova, He Wang, Yaoyao Wu, Dorothea Przybilla, Reinhold Schäfer, Zihao Chen, Shaoxing Zhu, Ulrich Keilholz   +8 more
doaj   +1 more source

Drug-Eluting Stents in Preclinical Studies [PDF]

Circulation: Cardiovascular Interventions, 2008
Coronary drug-eluting stents are commonplace in clinical practice with acceptable safety and efficacy. Preclinical evaluation of novel drug-eluting stent technologies has great importance for understanding safety and possibly efficacy of these technologies, and well-defined preclinical testing methods clearly benefit multiple communities within the ...
Robert S, Schwartz, Elazer, Edelman, Renu, Virmani, Andrew, Carter, Juan F, Granada, Greg L, Kaluza, Nicolas A F, Chronos, Keith A, Robinson, Ron, Waksman, Judah, Weinberger, Gregory J, Wilson, Robert L, Wilensky   +11 more
openaire   +2 more sources

Assessing Drug-Induced Mitochondrial Toxicity in Cardiomyocytes: Implications for Preclinical Cardiac Safety Evaluation

Pharmaceutics, 2022
Drug-induced cardiotoxicity not only leads to the attrition of drugs during development, but also contributes to the high morbidity and mortality rates of cardiovascular diseases. Comprehensive testing for proarrhythmic risks of drugs has been applied in
Xiaoli Tang, Zengwu Wang, Shengshou Hu, Bingying Zhou   +3 more
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Pre-Clinical Tools for Predicting Drug Efficacy in Treatment of Tuberculosis

Microorganisms, 2022
Combination therapy has, to some extent, been successful in limiting the emergence of drug-resistant tuberculosis. Drug combinations achieve this advantage by simultaneously acting on different targets and metabolic pathways.
Hasmik Margaryan, Dimitrios D. Evangelopoulos, Leticia Muraro Wildner, Timothy D. McHugh   +3 more
doaj   +1 more source

Computational Approaches in Preclinical Studies on Drug Discovery and Development

Frontiers in Chemistry, 2020
Because undesirable pharmacokinetics and toxicity are significant reasons for the failure of drug development in the costly late stage, it has been widely recognized that drug ADMET properties should be considered as early as possible to reduce failure ...
Fengxu Wu, Fengxu Wu, Yuquan Zhou, Yuquan Zhou, Langhui Li, Langhui Li, Xianhuan Shen, Xianhuan Shen, Ganying Chen, Ganying Chen, Xiaoqing Wang, Xiaoqing Wang, Xianyang Liang, Xianyang Liang, Mengyuan Tan, Mengyuan Tan, Zunnan Huang, Zunnan Huang, Zunnan Huang   +18 more
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Study on Research and Development Status and Application of 90Y Microspheres

Journal of Isotopes, 2022
With 90Y microspheres, radioactive microspheres are perfused to tumor feeding arteries through minimally invasive intervention, and then diffused and retained in small vessels of tumor terminals along with blood flow, so as to high selectively kill tumor
GAO Jie;LIU Xiaoming;ZHOU Wenhua;WANG Hongliang;ZHAO Xiaosheng;GE Qiang;LI Jianguo
doaj  

In vitro bactericidal activities of two novel dihydropyridine derivatives against Mycobacterium tuberculosis

Journal of Infection in Developing Countries, 2017
Introduction: Introducing new and effective antitubercular agents is important in tuberculosis control programs. In this study, the in vitro antitubercular activity of two novel 1,4-dihydropyridine derivatives (F-27, Cl-33) were screened against a total
Mehdi Zandhaghighi, Farzin Hadizadeh, Saman Soleimanpour, Zahra Meshkat, Seyed Abdolrahim Rezaee, Mohammad Derakhshan, Kiarash Ghazvini   +6 more
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Synthetic Studies to Help Elucidate the Metabolism of the Preclinical Candidate TBAJ-876—A Less Toxic and More Potent Analogue of Bedaquiline

Molecules, 2020
Bedaquiline is a novel drug approved in 2012 by the FDA for treatment of drug-resistant tuberculosis (TB). Although it shows high efficacy towards drug-resistant forms of TB, its use has been limited by the potential for significant side effects.
Peter J. Choi, Daniel Conole, Hamish S. Sutherland, Adrian Blaser, Amy S.T. Tong, Christopher B. Cooper, Anna M. Upton, Brian D. Palmer, William A. Denny   +8 more
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Effects of a new thyrotropic drug isolated from Potentilla alba on the male reproductive system of rats and offspring development

BMC Complementary Medicine and Therapies, 2021
Background The dysfunction of the thyroid gland is a common medical condition. Nowadays, patients frequently use medicinal herbs as complementary or alternative options to conventional drug treatments. These patients may benefit from treatment of thyroid
Lubov V. Krepkova, Valentina V. Bortnikova, Aleksandra N. Babenko, Praskovya G. Mizina, Vladimir A. Mkhitarov, Kathleen M. Job, Catherine M. Sherwin, Elena Y. Enioutina   +7 more
doaj   +1 more source

Hydrogel-Based Strategies for the Prevention and Treatment of Radiation-Induced Skin Injury: Progress and Mechanistic Insights

Biomimetics
Radiation-induced skin injury (RISI) is one of the most common complications of radiotherapy, severely compromising patients’ quality of life. However, no standardized treatment has yet been established.
Yinhui Wang, Huan Liu, Yushan He, Mei Li, Jie Gao, Zongtai Han, Jiayu Zhou, Jianguo Li   +7 more
doaj   +1 more source