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Evaluation of Nanoparticle Drug-Delivery Systems used in Preclinical Studies
Therapeutic Delivery, 2021Multifunctional nanoparticles have been identified as a promising drug-delivery system for sustainable drug release. The structural and size tunability and disease-targeting ability of nanoparticles have made them more suitable for multiple drug loading and delivery, thereby enhancing therapeutic results through synergistic effects.
Nagaraja Sreeharsha +3 more
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Preclinical evaluation of UC781 microbicide vaginal drug delivery
Drug Delivery and Translational Research, 2011UC781 is a potent nonnucleoside reverse transcriptase inhibitor being investigated as a potential microbicide to prevent transmission of HIV-1 both vaginally and rectally. This study was designed to investigate the in vitro drug release, in vitro permeability/safety, and in vivo pharmacokinetics in rabbits of a vaginal gel prepared with micronized or ...
David R. Friend +3 more
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Bupropion-induced convulsions: Preclinical evaluation of antiepileptic drugs
Epilepsy Research, 2005Bupropion, a unique, non-nicotine smoking cessation aid and an effective antidepressant, is well known to produce seizures following overdosing in humans. However, the experimental background for the usefulness of antiepileptic drugs in the protection against bupropion-induced convulsions has not been established yet.
Tomasz Mróz +4 more
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Technological Advances in Preclinical Drug Evaluation: The Role of -Omics Methods
Current Medicinal Chemistry, 2020Preclinical drug development is an essential step in the drug development process where the evaluation of new chemical entities occurs. In particular, preclinical drug development phases include deep analysis of drug candidates’ interactions with biomolecules/targets, their safety, toxicity, pharmacokinetics, metabolism by use of assays in vitro and ...
Radan Spaventi +4 more
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Evaluation of Drug Candidates for Preclinical Development [PDF]
, 2009 Evaluation of drug candidates for preclinical development , Evaluation of drug candidates for preclinical development , کتابخانه مرکزی دانشگاه علوم پزشکی ...
Chao Han, Charles B. Davis, Binghe Wang
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Evaluating the efficacy of prototype antiseizure drugs using a preclinical pharmacokinetic approach
Epilepsia, 2022SummaryObjectivePharmacokinetics (PK) of a drug drive its exposure, efficacy, and tolerability. A thorough preclinical PK assessment of antiseizure medications (ASMs) is therefore essential to evaluate the clinical potential. We tested protection against evoked seizures of prototype ASMs in conjunction with analysis of plasma and brain PK as a proof-of-
Jeffrey A. Mensah +5 more
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NCI Specialized Procedures in Preclinical Drug Evaluations
2004Agents now come to the U.S. National Cancer Institute (NCI) from many sources for preclinical evaluation and/or potential development (1). In most cases, experimental agents have limited antiproliferative data against a broad spectrum of human cancers, and these agents usually are then tested in the NCI’ s in vitro anticancer drug screen. Data from the
Michael C. Alley +4 more
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Treatment of schizophrenia: A clinical and preclinical evaluation of neuroleptic drugs
Pharmacology & Therapeutics, 1993Forty years after the first clinical report on the effectiveness of chlorpromazine in psychiatric patients, neuroleptic drugs are still the most widely used drugs in the treatment of schizophrenia. Indeed, there are no other drugs which have proven to be as effective in the treatment of this severe psychiatric disorder.
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Human skin-on-a-chip for mpox pathogenesis studies and preclinical drug evaluation
Trends in Pharmacological Sciences, 2023Timely intervention of preventative and therapeutic measures abated a 2022 mpox global outbreak. However, the high transmissibility and unique pathological characteristics of mpox demand further investigation. Here, we discuss the potentials of human skin-on-a-chip as a valuable model for mpox disease evaluation, to achieve in-depth physiological ...
Jia Zhu, Hasan E. Abaci
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