Results 261 to 270 of about 265,822 (283)
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Orthotopic models of cancer for preclinical drug evaluation
European Journal of Cancer, 2004Considering the enormous effort that has taken place over the years to discover new chemotherapeutic drugs for treating the common cancers, the conventional murine and xenograft test systems used to test efficacy for drug development have identified only a limited number of useful agents that are active clinically at well tolerated doses.
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Drug Discovery Today, 2023
The formation of reactive metabolites (RMs) is thought to be one of the pathogeneses for some idiosyncratic adverse drug reactions (IADRs) which are considered one of the leading causes of some drug attritions and/or recalls. Minimizing or eliminating the formation of RMs via chemical modification is a useful tactic to reduce the risk of IADRs and time-
Chunyong, He, Yuchang, Mao, Hong, Wan
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The formation of reactive metabolites (RMs) is thought to be one of the pathogeneses for some idiosyncratic adverse drug reactions (IADRs) which are considered one of the leading causes of some drug attritions and/or recalls. Minimizing or eliminating the formation of RMs via chemical modification is a useful tactic to reduce the risk of IADRs and time-
Chunyong, He, Yuchang, Mao, Hong, Wan
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Preclinical evaluation of behavioral deficits following hypnotic drug treatment
Pharmacology Biochemistry and Behavior, 1986Most hypnotic medications result in performance decrements, or "hangover effects," the morning after bedtime ingestion. However, the severity of hangover effects with new compounds is difficult to predict prior to clinical trials. This paper describes a preclinical procedure that is predictive of human hangover effects following bedtime ingestion of ...
Louis C. Iorio +2 more
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The Scientific Basis of Drug-Drug Interactions: Mechanism and Preclinical Evaluation
Drug Information Journal, 1998Pharmacokinetic drug-drug interactions (PDDI), in which the pharmacokinetic clearance of one drug is altered by a coadministered drug, can be divided mechanistically into two general categories: 1. Inhibitory PDDI—the inhibition of the metabolic clearance of one drug by a coadministered drug, and 2.
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Automated electrophysiology in the preclinical evaluation of drugs for potential QT prolongation
Journal of Pharmacological and Toxicological Methods, 2005The human ether-a-go-go-related gene (hERG) potassium channel plays a major role in the electrical conductances involved in human heart repolarization. Drugs that decrease hERG K(+) currents are at risk to produce a prolongation of the cardiac action potential, resulting in an increase of the QT interval.
Liang Guo, Heather Guthrie
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EGFR-targeted anti-cancer drugs in radiotherapy: Preclinical evaluation of mechanisms
Radiotherapy and Oncology, 2007Preclinical and clinical results indicate that the EGFR can mediate radioresistance in different solid human tumours. Combination of radiotherapy and EGFR inhibitors can improve local tumour control compared to irradiation alone and has been introduced into clinical radiotherapy practice.
Michael Baumann +6 more
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Preclinical evaluation of the urokinase receptor-derived peptide UPARANT as an anti-inflammatory drug [PDF]
Inflammation Research, 2017 Inflammation plays a key role in the pathogenesis of several chronic diseases. The urokinase plasminogen activator receptor (uPAR) exerts a plethora of functions in both physiological and pathological processes, including inflammation.In this study, we evaluated the anti-inflammatory effect of a novel peptide ligand of uPAR, UPARANT, in different ...
Boccella, Serena +7 more
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Preclinical Drug Evaluation with Human Melanoma Xenografts
1988In 1974 there was an increasing awareness at the National Cancer Institute of the U.S.A. that important drugs might have been missed by the conventional murine tumor screening system then employed. Differences in biochemistry and cell biology of murine vs. human tumors were increasingly well understood.
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Expert Opinion on Drug Discovery, 2011
There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span, maintaining normal physiological function, and alleviating the onset and severity of age-associated diseases. This review looks at the current screening approaches used to evaluate the efficacy of such
Peter А Egormin +14 more
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There is a growing scientific and public interest in the development of new antiaging drugs for the purposes of extending mean and/or maximum life span, maintaining normal physiological function, and alleviating the onset and severity of age-associated diseases. This review looks at the current screening approaches used to evaluate the efficacy of such
Peter А Egormin +14 more
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ChemInform Abstract: Drug Safety Evaluation at the Preclinical Stage
ChemInform, 1991AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
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