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Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators [PDF]

Biomedicines, 2023
Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu, Wan-Chun Chang, Shih-Cheng Pao, Shuen-Iu Hung   +3 more
doaj   +3 more sources

Drug hypersensitivity in drug-resistant tuberculosis [PDF]

World Allergy Organization Journal, 2023
Objective: To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods: This was a retrospective study.
Zeynep Yegin Katran, MD, İsmet Bulut, MD, Aylin Babalık, MD, Metin Keren, MD, Fatma Merve Tepetam, MD, Selver Seda Mersin, MD, Cihan Örçen, MD, Tuğçe Yakut, MD, Dilek Yavuz, MD   +8 more
doaj   +4 more sources

The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity

Frontiers in Immunology, 2021
The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu, Yun-Shiuan Olivia Hsu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Yun Fu, Yun Fu, Yun Fu, Yun Fu, Chuang-Wei Wang, Chuang-Wei Wang, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Yu-Fen Lin, Yu-Fen Lin, Wen-Cheng Chang, Wen-Cheng Chang, Wen-Cheng Chang, Kun-Yun Yeh, Kun-Yun Yeh, Shuen-Iu Hung, Shuen-Iu Hung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen   +43 more
doaj   +2 more sources

Desensitization for the prevention of drug hypersensitivity reactions. [PDF]

Korean J Intern Med, 2022
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose.
Kang SY, Seo J, Kang HR.
europepmc   +2 more sources

An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity

Journal of Immunology Research, 2018
Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced ...
Chun-Bing Chen, Riichiro Abe, Ren-You Pan, Chuang-Wei Wang, Shuen-Iu Hung, Yi-Giien Tsai, Wen-Hung Chung   +6 more
doaj   +2 more sources

Variability of the Genes Involved in the Cellular Redox Status and Their Implication in Drug Hypersensitivity Reactions

Antioxidants, 2021
Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics.
Pedro Ayuso, Elena García-Martín, José A. G. Agúndez   +2 more
doaj   +2 more sources

Viral infections and drug hypersensitivity

Allergy, 2022
Virus infections and T‐cell‐mediated drug hypersensitivity reactions (DHR) can influence each other. In most instances, systemic virus infections appear first.
W. Pichler, M. Brüggen
semanticscholar   +3 more sources

Multiple Drug Hypersensitivity [PDF]

International Archives of Allergy and Immunology, 2017
Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs.
W. Pichler, Y. Srinoulprasert, J. Yun, O. Hausmann   +3 more
semanticscholar   +4 more sources

Hypersensitivity to Antituberculous Drugs [PDF]

BMJ, 1964
J. H. Mitchell
openalex   +5 more sources

Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions

Frontiers in Immunology, 2018
The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to
Grzegorz Porebski, Kamila Kwiecien, Magdalena Pawica, Mateusz Kwitniewski   +3 more
doaj   +2 more sources