High occurrence of simultaneous multiple-drug hypersensitivity syndrome induced by first-line anti-tuberculosis drugs [PDF]
World Allergy Organization Journal, 2021 Background: Multiple drug hypersensitivity syndrome (MDHS) results in treatment delay or failure and often results in severe drug hypersensitivity reactions.
Da Woon Sim +3 more
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Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators [PDF]
Biomedicines, 2023 Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu +3 more
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The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity
Frontiers in Immunology, 2021 The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu +43 more
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Frontiers in Pharmacology, 2022 Vancomycin is a commonly used antibiotic; however, it can cause life-threatening severe cutaneous adverse reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS).
Chuang-Wei Wang +42 more
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The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]
, 2013 Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József +7 more
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Folia Medica Indonesiana, 2021 Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological
Nur Moya Isyroqiyyah +2 more
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Multiple Drug Hypersensitivity [PDF]
International Archives of Allergy and Immunology, 2017 Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS).
Werner J, Pichler +3 more
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Hypersensitivity reactions to small molecule drugs
Frontiers in Immunology, 2022 Drug hypersensitivity reactions induced by small molecule drugs encompass a broad spectrum of adverse drug reactions with heterogeneous clinical presentations and mechanisms.
Jiayin Han +6 more
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Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study [PDF]
, 2005 Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle.
Almeida, C. +5 more
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Update on pathobiology in Stevens-Johnson syndrome and toxic epidermal necrolysis
Dermatologica Sinica, 2013 Stevens-Johnson syndrome (SJS) and toxic epidermal necrosis (TEN) are rare but life-threatening severe cutaneous adverse reactions (SCARs), which are mainly induced by a variety of drugs. Once considered to be unpredictable, significant progress has been
Shih-Chi Su, Wen-Hung Chung
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