Results 1 to 10 of about 3,911,739 (284)
Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators [PDF]
Biomedicines, 2023 Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu +3 more
doaj +3 more sources
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity [PDF]
Frontiers in Immunology, 2021 The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu +43 more
doaj +3 more sources
Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions [PDF]
Frontiers in Immunology, 2018 The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to
Grzegorz Porebski +3 more
doaj +5 more sources
Drug hypersensitivity in drug-resistant tuberculosis [PDF]
World Allergy Organization Journal, 2023 Objective: To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods: This was a retrospective study.
Zeynep Yegin Katran, MD +8 more
doaj +4 more sources
An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity
Journal of Immunology Research, 2018 Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced ...
Chun-Bing Chen +6 more
doaj +2 more sources
Drug hypersensitivity in students from São Paulo, Brazil [PDF]
Clinics, 2010 BACKGROUND: Drug hypersensitivity is responsible for substantial mortality and morbidity, and increased health costs. However, epidemiological data on drug hypersensitivity in general or specific populations are scarce.
Luis Felipe Chiaverini Ensina +5 more
doaj +7 more sources
Viral infections and drug hypersensitivity
Allergy, 2022 AbstractVirus infections and T‐cell‐mediated drug hypersensitivity reactions (DHR) can influence each other. In most instances, systemic virus infections appear first. They may prime the reactivity to drugs in two ways: First, by virus‐induced second signals: certain drugs like β‐lactam antibiotics are haptens and covalently bind to various soluble and
Werner J. Pichler +1 more
openaire +3 more sources
Pharmacogenetics of hypersensitivity drug reactions [PDF]
Therapies, 2017 Adverse drug reactions are a significant cause of morbidity and mortality and represent a major burden on the healthcare system. Some of those reactions are immunologically mediated (hypersensitivity reactions) and can be clinically subdivided into two ...
Becquemont, Laurent, Negrini, Simone
core +6 more sources
Multiple Drug Hypersensitivity [PDF]
International Archives of Allergy and Immunology, 2017 Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS).
Werner J. Pichler +3 more
openaire +4 more sources