Results 1 to 10 of about 4,057,983 (352)
Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators. [PDF]
Biomedicines, 2023 Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Chu MT, Chang WC, Pao SC, Hung SI.
europepmc +4 more sources
Desensitization for the prevention of drug hypersensitivity reactions. [PDF]
Korean J Intern Med, 2022 Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose.
Kang SY, Seo J, Kang HR.
europepmc +2 more sources
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity
Frontiers in Immunology, 2021 The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Y. Hsu +10 more
semanticscholar +3 more sources
Antioxidants, 2021 Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics.
P. Ayuso +2 more
semanticscholar +3 more sources
Allergy. European Journal of Allergy and Clinical Immunology, 2023 Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests.
C. Mayorga +11 more
semanticscholar +1 more source
Viral infections and drug hypersensitivity
Allergy. European Journal of Allergy and Clinical Immunology, 2022 Virus infections and T‐cell‐mediated drug hypersensitivity reactions (DHR) can influence each other. In most instances, systemic virus infections appear first.
W. Pichler, M. Brüggen
semanticscholar +1 more source
An Updated Review of the Diagnostic Methods in Delayed Drug Hypersensitivity
Frontiers in Pharmacology, 2021 Delayed drug hypersensitivity reactions are clinically diverse reactions that vary from isolated benign skin conditions that remit quickly with no or symptomatic treatment, drug discontinuation or even continued drug treatment, to the other extreme of ...
A. Copaescu +4 more
semanticscholar +1 more source
The important role of non‐covalent drug‐protein interactions in drug hypersensitivity reactions
Allergy. European Journal of Allergy and Clinical Immunology, 2021 Drug hypersensitivity reactions (DHR) are heterogeneous and unusual immune reactions with rather unique clinical presentations. Accumulating evidence indicates that certain non‐covalent drug‐protein interactions are able to elicit exclusively effector ...
W. Pichler
semanticscholar +1 more source
The newly developed CRF1-receptor antagonists, NGD 98-2 and NGD 9002, suppress acute stress-induced stimulation of colonic motor function and visceral hypersensitivity in rats. [PDF]
, 2013 Corticotropin releasing factor receptor 1 (CRF1) is the key receptor that mediates stress-related body responses. However to date there are no CRF1 antagonists that have shown clinical efficacy in stress-related diseases.
Czimmer, József +7 more
core +7 more sources
International Journal of Molecular Sciences, 2021 Drug-induced hypersensitivity syndrome/drug reaction with eosinophilia and systemic symptoms (DIHS/DRESS) is a severe type of adverse drug eruption associated with multiorgan involvement and the reactivation of human herpesvirus 6, which arises after ...
F. Miyagawa, H. Asada
semanticscholar +1 more source