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Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators [PDF]

Biomedicines, 2023
Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu, Wan-Chun Chang, Shih-Cheng Pao, Shuen-Iu Hung   +3 more
doaj   +3 more sources

The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity

Frontiers in Immunology, 2021
The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu, Yun-Shiuan Olivia Hsu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Yun Fu, Yun Fu, Yun Fu, Yun Fu, Chuang-Wei Wang, Chuang-Wei Wang, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Yu-Fen Lin, Yu-Fen Lin, Wen-Cheng Chang, Wen-Cheng Chang, Wen-Cheng Chang, Kun-Yun Yeh, Kun-Yun Yeh, Shuen-Iu Hung, Shuen-Iu Hung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen   +43 more
doaj   +2 more sources

High occurrence of simultaneous multiple-drug hypersensitivity syndrome induced by first-line anti-tuberculosis drugs [PDF]

World Allergy Organization Journal, 2021
Background: Multiple drug hypersensitivity syndrome (MDHS) results in treatment delay or failure and often results in severe drug hypersensitivity reactions.
Da Woon Sim, Hye Su You, Ji Eun Yu, Young-Il Koh   +3 more
doaj   +2 more sources

Drug hypersensitivity in drug-resistant tuberculosis [PDF]

World Allergy Organization Journal, 2023
Objective: To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods: This was a retrospective study.
Zeynep Yegin Katran, MD, İsmet Bulut, MD, Aylin Babalık, MD, Metin Keren, MD, Fatma Merve Tepetam, MD, Selver Seda Mersin, MD, Cihan Örçen, MD, Tuğçe Yakut, MD, Dilek Yavuz, MD   +8 more
doaj   +2 more sources

CNS tuberculoma in an immunocompetent patient: A case report of multi-drug hypersensitivity to RIPE therapy. [PDF]

IDCases, 2023
Huber B, Joshi S.
europepmc   +2 more sources

Drug Rash With Eosinophilia and Systemic Symptoms (DRESS) Due to Multiple Anti-Epileptic Drug Hypersensitivity. [PDF]

Cureus
Ajon ARS, Camara PTA.
europepmc   +3 more sources

Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population

Frontiers in Pharmacology, 2022
Vancomycin is a commonly used antibiotic; however, it can cause life-threatening severe cutaneous adverse reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS).
Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Wei-Chen Lin, Wei-Chen Lin, Wei-Ti Chen, Wei-Ti Chen, Wei-Ti Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Hsin-Han Hou, Rosaline Chung-Yee Hui, Rosaline Chung-Yee Hui, Jennifer Wu, Jennifer Wu, Jennifer Wu, Chih-Jung Chang, Chih-Jung Chang, Ya-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Taiwan Severe Cutaneous Adverse Reaction Consortium   +42 more
doaj   +1 more source

Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation

Folia Medica Indonesiana, 2021
Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological
Nur Moya Isyroqiyyah, Gatot Soegiarto, Yuani Setiawati   +2 more
doaj   +1 more source

Hypersensitivity reactions to small molecule drugs

Frontiers in Immunology, 2022
Drug hypersensitivity reactions induced by small molecule drugs encompass a broad spectrum of adverse drug reactions with heterogeneous clinical presentations and mechanisms.
Jiayin Han, Chen Pan, Xuan Tang, Qi Li, Yan Zhu, Yushi Zhang, Aihua Liang   +6 more
doaj   +1 more source

Prospective genetic screening decreases the incidence of Abacavir hypersensitivity reactions in the Western Australian HIV cohort study [PDF]

, 2005
Abacavir therapy is associated with significant drug hypersensitivity in ∼8% of recipients, with retrospective studies indicating a strong genetic association with the HLA-B*5701 allelle.
Almeida, C., Mallal, S., Martin, A., McKinnon, E., Nolan, D., Rauch, A.   +5 more
core   +2 more sources