Results 1 to 10 of about 84,439 (181)

Drug hypersensitivity in students from São Paulo, Brazil [PDF]

Clinics, 2010
BACKGROUND: Drug hypersensitivity is responsible for substantial mortality and morbidity, and increased health costs. However, epidemiological data on drug hypersensitivity in general or specific populations are scarce.
Luis Felipe Chiaverini Ensina, Maria Helena Lopes Amigo, Thais Koch, Evelyn Guzman, Renata Paoli, Inês Cristina Camelo Nunes   +5 more
doaj   +7 more sources

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve immune mechanisms, and genetic association studies have identified strong linkage between drug ...
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
arxiv   +6 more sources

Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions [PDF]

Frontiers in Immunology, 2018
The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to
Grzegorz Porebski, Kamila Kwiecien, Magdalena Pawica, Mateusz Kwitniewski   +3 more
doaj   +4 more sources

Diclofenac Hypersensitivity: Antibody Responses to the Parent Drug and Relevant Metabolites [PDF]

, 2010
Background: Hypersensitivity reactions against nonsteroidal antiinflammatory drugs (NSAIDs) like diclofenac (DF) can manifest as Type I-like allergic reactions including systemic anaphylaxis.
A Ding, A Hartl, A Salama, A Szczeklik, AB Riemer, AJ Bircher, AL de Weck, Andrea Harrer, C Sirichaiwat, D Bougie, Derya Unutmaz, DJ Naisbitt, Fatima Ferreira, G Tojo, G Wilkinson, GJ Mulder, H Karasuyama, H Spahn-Langguth, J Ring, J Wen, JR Kenny, L Jackson Roberts, L Vogel, Lothar Vogel, M Guzman, M Himly, M Himly, Martin Himly, MH Bluth, Michaela Braitsch, NR Pumford, PZ Zia-Amirhosseini, R Asero, R Bort, Robert Grims, Roland Lang, S Kaul, Thomas Hawranek, V Kvedariene, W Aberer, W Tang, W Tang, W Tang, Walther Schmid, Werner Aberer, Z Yan   +45 more
core   +12 more sources

Drug Hypersensitivity Associated with Dental Treatments [PDF]

Pesquisa Brasileira em Odontopediatria e Clínica Integrada
Objective: To characterize drug hypersensitivity associated with dental treatments. Material and Methods: Data from 5,302 dental patients extracted from the Faculty of Dental Medicine were used to investigate drug use history, drug hypersensitivity, and ...
Ricardo Dias de Castro, Mariana Bezamat, Alexandre Rezende Vieira   +2 more
doaj   +2 more sources

Hypersensitivity reactions to anticoagulant drugs: diagnosis and management options [PDF]

Allergy: European Journal of Allergy and Clinical Immunology, 2006
Andreas J. Bircher, T. Harr, L. Hohenstein, Dimitrios A. Tsakiris   +3 more
exaly   +2 more sources

The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity

Frontiers in Immunology, 2021
The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu, Yun-Shiuan Olivia Hsu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Kun-Lin Lu, Yun Fu, Yun Fu, Yun Fu, Yun Fu, Chuang-Wei Wang, Chuang-Wei Wang, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Yu-Fen Lin, Yu-Fen Lin, Wen-Cheng Chang, Wen-Cheng Chang, Wen-Cheng Chang, Kun-Yun Yeh, Kun-Yun Yeh, Shuen-Iu Hung, Shuen-Iu Hung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen   +43 more
doaj   +1 more source

Associations of HLA-A and HLA-B with vancomycin-induced drug reaction with eosinophilia and systemic symptoms in the Han-Chinese population

Frontiers in Pharmacology, 2022
Vancomycin is a commonly used antibiotic; however, it can cause life-threatening severe cutaneous adverse reactions, such as drug reaction with eosinophilia and systemic symptoms (DRESS).
Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Chuang-Wei Wang, Wei-Chen Lin, Wei-Chen Lin, Wei-Ti Chen, Wei-Ti Chen, Wei-Ti Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Bing Chen, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Chun-Wei Lu, Hsin-Han Hou, Rosaline Chung-Yee Hui, Rosaline Chung-Yee Hui, Jennifer Wu, Jennifer Wu, Jennifer Wu, Chih-Jung Chang, Chih-Jung Chang, Ya-Ching Chang, Ya-Ching Chang, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Wen-Hung Chung, Taiwan Severe Cutaneous Adverse Reaction Consortium   +42 more
doaj   +1 more source

Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators

Biomedicines, 2023
Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu, Wan-Chun Chang, Shih-Cheng Pao, Shuen-Iu Hung   +3 more
doaj   +1 more source

Profile of Drug Hypersensitivity Patients Hospitalized in Dr. Soetomo Hospital, Surabaya, Indonesia: Preliminary Data of 6 Months Observation

Folia Medica Indonesiana, 2021
Drug hypersensitivity is defined as an untoward response to medication which is noxious and unintended, and which occurs at doses normally used in human either for the prophylaxis, diagnosis, or therapy of disease or for the modification of physiological
Nur Moya Isyroqiyyah, Gatot Soegiarto, Yuani Setiawati   +2 more
doaj   +1 more source