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Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators [PDF]
Biomedicines, 2023 Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu +3 more
doaj +3 more sources
The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity
Frontiers in Immunology, 2021 The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu +43 more
doaj +2 more sources
Desensitization for the prevention of drug hypersensitivity reactions. [PDF]
Korean J Intern Med, 2022 Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose.
Kang SY, Seo J, Kang HR.
europepmc +2 more sources
Recognizing Drug Hypersensitivity in Pigmented Skin. [PDF]
Immunol Allergy Clin North Am, 2022 The imagery of pigmented skin is underrepresented in teaching materials such as textbooks, journals, and online references, and this has resulted in poorer diagnostic and management outcomes of skin pathology, including delayed cutaneous drug ...
Lehloenya RJ +3 more
europepmc +2 more sources
Drug hypersensitivity in drug-resistant tuberculosis [PDF]
World Allergy Organization Journal, 2023 Objective: To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods: This was a retrospective study.
Zeynep Yegin Katran, MD +8 more
doaj +2 more sources
An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity
Journal of Immunology Research, 2018 Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced ...
Chun-Bing Chen +6 more
doaj +2 more sources
Multiple Drug Hypersensitivity [PDF]
International Archives of Allergy and Immunology, 2017 Multiple drug hypersensitivity (MDH) is a syndrome that develops as a consequence of massive T-cell stimulations and is characterized by long-lasting drug hypersensitivity reactions (DHR) to different drugs. The initial symptoms are mostly severe exanthems or drug rash with eosinophilia and systemic symptoms (DRESS).
Werner J, Pichler +3 more
openaire +3 more sources
Antioxidants, 2021 Adverse drug reactions are a major cause of morbidity and mortality. Of the great diversity of drugs involved in hypersensitivity drug reactions, the most frequent are non-steroidal anti-inflammatory drugs followed by β-lactam antibiotics.
Pedro Ayuso +2 more
doaj +2 more sources
Allergy. European Journal of Allergy and Clinical Immunology, 2023 Diagnosing immediate drug hypersensitivity reactions (IDHRs) can pose a significant challenge and there is an urgent need for safe and reliable tests.
C. Mayorga +11 more
semanticscholar +1 more source
Biomarkers of immediate drug hypersensitivity
Allergy. European Journal of Allergy and Clinical Immunology, 2023 Immediate drug hypersensitivity reactions (IDHRs) are a burden for patients and the health systems. This problem increases when taking into account that only a small proportion of patients initially labelled as allergic are finally confirmed after an ...
C. Mayorga +5 more
semanticscholar +1 more source