Delayed Drug Hypersensitivity Reactions: Molecular Recognition, Genetic Susceptibility, and Immune Mediators [PDF]
Drug hypersensitivity reactions are classified into immediate and delayed types, according to the onset time. In contrast to the immediate type, delayed drug hypersensitivity mainly involves T lymphocyte recognition of the drug antigens and cell ...
Mu-Tzu Chu+3 more
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The Roles of Immunoregulatory Networks in Severe Drug Hypersensitivity [PDF]
The immunomodulatory effects of regulatory T cells (Tregs) and co-signaling receptors have gained much attention, as they help balance immunogenic and immunotolerant responses that may be disrupted in autoimmune and infectious diseases.
Yun-Shiuan Olivia Hsu+43 more
doaj +3 more sources
Drug hypersensitivity in drug-resistant tuberculosis [PDF]
Objective: To evaluate drug resıstant tuberculosis patients who developed drug hypersensitivity to antituberculosis drug. Methods: This was a retrospective study.
Zeynep Yegin Katran, MD+8 more
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Mas-Related G Protein-Coupled Receptor-X2 (MRGPRX2) in Drug Hypersensitivity Reactions [PDF]
The human ortholog MRGPRX2 and the mice ortholog, Mrgprb2 are activated by basic secretagogues and neurokinins. A number of commonly used small-molecule drugs (e.g., neuromuscular blocking agents, fluoroquinolones, vancomycin) have been recently shown to
Grzegorz Porebski+3 more
doaj +5 more sources
Desensitization for the prevention of drug hypersensitivity reactions. [PDF]
Drug desensitization is the temporary induction of tolerance to a sensitized drug by administering slow increments of the drug, starting from a very small amount to a full therapeutic dose.
Kang SY, Seo J, Kang HR.
europepmc +2 more sources
An Updated Review of the Molecular Mechanisms in Drug Hypersensitivity
Drug hypersensitivity may manifest ranging from milder skin reactions (e.g., maculopapular exanthema and urticaria) to severe systemic reactions, such as anaphylaxis, drug reactions with eosinophilia and systemic symptoms (DRESS)/drug-induced ...
Chun-Bing Chen+6 more
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Drug hypersensitivity in students from São Paulo, Brazil [PDF]
BACKGROUND: Drug hypersensitivity is responsible for substantial mortality and morbidity, and increased health costs. However, epidemiological data on drug hypersensitivity in general or specific populations are scarce.
Luis Felipe Chiaverini Ensina+5 more
doaj +7 more sources
Viral infections and drug hypersensitivity
AbstractVirus infections and T‐cell‐mediated drug hypersensitivity reactions (DHR) can influence each other. In most instances, systemic virus infections appear first. They may prime the reactivity to drugs in two ways: First, by virus‐induced second signals: certain drugs like β‐lactam antibiotics are haptens and covalently bind to various soluble and
Werner J. Pichler+1 more
openaire +3 more sources
Repurposing HLA genotype data of renal transplant patients to prevent severe drug hypersensitivity reactions. [PDF]
Introduction: Specific alleles in human leukocyte antigens (HLAs) are associated with an increased risk of developing drug hypersensitivity reactions induced by abacavir, allopurinol, carbamazepine, oxcarbazepine, phenytoin, lamotrigine, or ...
Manson LEN+6 more
europepmc +3 more sources
Pharmacogenetics of hypersensitivity drug reactions [PDF]
Adverse drug reactions are a significant cause of morbidity and mortality and represent a major burden on the healthcare system. Some of those reactions are immunologically mediated (hypersensitivity reactions) and can be clinically subdivided into two ...
Becquemont, Laurent, Negrini, Simone
core +6 more sources