Results 31 to 40 of about 222,974 (348)

Action following the discovery of a global association between the whole genome and adverse event risk in a clinical drug-development programme [PDF]

, 2008
Observation of adverse drug reactions during drug development can cause closure of the whole programme. However, if association between the genotype and the risk of an adverse event is discovered, then it might suffice to exclude patients of certain ...
Breiman, Breslow, Dudbridge, Díaz-Uriarte, Efron, Fielding, Genkin, Graven, Hastie, Izmirlian, Kelly, Lindley, Park, Ripley, Roses, Roses, Tibshirani, Troyanskaya, Wille, Xiong, Yuan, Zaykin   +21 more
core   +1 more source

HLA Associations and Clinical Implications in T-Cell Mediated Drug Hypersensitivity Reactions: An Updated Review

Journal of Immunology Research, 2014
T-cell mediated drug hypersensitivity reactions may range from mild rash to severe fatal reactions. Among them, drug reaction with eosinophilia and systemic symptoms (DRESS) or drug-induced hypersensitivity syndrome (DIHS), Stevens-Johnson syndrome ...
Chi-Yuan Cheng, Shih-Chi Su, Chi-Hua Chen, Wei-Li Chen, Shin-Tarng Deng, Wen-Hung Chung   +5 more
doaj   +1 more source

A Novel System to Diagnose Cutaneous Adverse Drug Reactions Employing the Cellscan—Comparison with Histamine Releasing Test and Inf-γ Releasing Test

Clinical and Developmental Immunology, 2005
Background: There are several mechanisms to describe allergic drug reactions yet the methods to diagnose them are limited.
Ilan Goldberg, Boris Gilburd, Martine Szyper Kravitz, Shmuel Kivity, Berta Ben Chaim, Tirza Klein, Yael Schiffenbauer, Ela Trubniykovr, Sarah Brenner, Yehuda Shoenfeld   +9 more
doaj   +1 more source

Mas-related G-protein–coupled receptors inhibit pathological pain in mice [PDF]

, 2010
An important objective of pain research is to identify novel drug targets for the treatment of pathological persistent pain states, such as inflammatory and neuropathic pain.
Altier, Baron, Basbaum, Cai, Calignano, Callaghan, Caterina, Chen, Chen, Coderre, Costigan, Costigan, D. J. Anderson, De Felipe, Delmas, Dong, Gerevich, Guan, Guan, Herrero, Honan, Ikeda, Julius, Knabl, Kusudo, Lembo, Li, Li, Liu, Liu, Lu, MacDermott, MacPherson, Malmberg, Melzack, Melzack, Miraucourt, Ndong, Neumann, Q. Liu, Rau, Rodriguez Parkitna, S. N. Raja, Scholz, Seal, Woolf, X. Dong, Y. Guan, Z. Tang, Zeng   +49 more
core   +2 more sources

The Induction of Oxidative/Nitrosative Stress, Inflammation, and Apoptosis by a Ferric Carboxymaltose Copy Compared to Iron Sucrose in a Non-Clinical Model [PDF]

, 2015
Introduction: Ferric carboxymaltose is a next-generation polynuclear iron(III)-hydroxide carbohydrate complex for intravenous iron therapy belonging to the class of so-called non-biological complex drugs.
Angerosa, Margarita, Cao, Gabriel Fernando, Toblli, Jorge Eduardo   +2 more
core   +1 more source

Clinical Characteristics and Disease Burden of Patients with Moderate-to-Severe Generalized Pustular Psoriasis Flares in Taiwan

Dermatology and Therapy
Introduction Generalized pustular psoriasis (GPP) is a rare and severe psoriasis subtype characterized by the rapid onset of coalescing sterile pustules over broad body areas and systemic inflammation.
Chun-Wei Lu, Chien-Yu Tseng, Chuang-Wei Wang, Shang-Hung Lin, Chun-Bing Chen, Rosaline Chung-Yee Hui, Ching-Chi Chi, Yu-Huei Huang, Chih-Hung Lee, Fang-Ju Lin, Wen-Hung Chung   +10 more
doaj   +1 more source

The Mechanism of Onychomadesis (Nail Shedding) and Beau’s Lines Following Hand-Foot-Mouth Disease

Viruses, 2019
Background: Nail changes, including onychomadesis (nail shedding) and Beau’s line, following hand-foot-mouth disease (HFMD) are a common emergence at the stage of late complications of HFMD. However, the exact mechanism is still unknown. Therefore,
Hsiu-Hui Chiu, Ming-Tsan Liu, Wen-Hung Chung, Yu-Shien Ko, Chin-Fang Lu, Cheng-Che E. Lan, Chun-Wei Lu, Kai-Che Wei   +7 more
doaj   +1 more source

A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors [PDF]

, 2019
Alcohol produces both stimulant and sedative effects in humans and rodents. In humans, alcohol abuse disorder is associated with a higher stimulant and lower sedative responses to alcohol.
Bocarsly, Miriam E., da Silva e Silva, Daniel, Dobbs, Lauren K., Kolb, Vanessa, Luderman, Kathryn D., Rubinstein, Marcelo, Shashikiran, Sannidhi, Sibley, David R., Álvarez, Verónica Alicia   +8 more
core   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Immune checkpoint inhibitor-induced severe epidermal necrolysis mediated by macrophage-derived CXCL10 and abated by TNF blockade

Nature Communications
Immune checkpoint inhibitors (ICI) represent new anticancer agents and have been used worldwide. However, ICI can potentially induce life-threatening severe cutaneous adverse reaction (SCAR), such as Stevens-Johnson syndrome/toxic epidermal necrolysis ...
Chun-Bing Chen, Shuen-Iu Hung, John Wen-Cheng Chang, Chan-Keng Yang, David Hui-Kang Ma, Yu-Chuan Teng, Chun-Wei Lu, Wei-Ti Chen, Hsiao-Yin Yang, Cheng-Chang Tsai, Chih Liang Wang, Pin-Hsuan Chiang, Jennifer Wu, Ya-Wen Tsai, Lai-Ying Lu, Yang Yu-Wei Lin, Rosaline Chung-Yee Hui, Fu-Mei Hsieh, Chao-Kai Hsu, Chaw-Ning Lee, Yi-Ju Chen, Chih-Chiang Chen, Yilei Cui, Hung-Chih Hsu, Ya-Ching Chang, Chih-Jung Chang, Ho-Chen Lin, Chee Jen Chang, Yu-Jr Lin, Cheng-Lung Ku, Chuang-Wei Wang, Wen-Hung Chung   +31 more
doaj   +1 more source