Results 111 to 120 of about 112,427 (348)

Immune or genetic-mediated disruption of CASPR2 causes pain hypersensitivity due to enhanced primary afferent excitability [PDF]

, 2018
Human autoantibodies to contactin-associated protein-like 2 (CASPR2) are often associated with neuropathic pain, and CASPR2 mutations have been linked to autism spectrum disorders, in which sensory dysfunction is increasingly recognized.
Bennett, David L., Buckley, Camilla, Carroll, Liam, Cervellini, Ilaria, Chisholm, Kim I., Clark, Alex J, Coutinho, Ester, Dawes, John M., Dickenson, Anthony H., Galino, Jorge, Giannoccaro, Maria Pia, Gutierrez-Mecinas, Maria, Iwagaki, Noboru, Jacobson, Leslie, Kuehn, Hannah, Kühnemund, Johannes, Lang, Bethan, Leite, M Isabel, Lewin, Gary R., McMahon, Stephen B., Menassa, David A., Middleton, Steven J., Patel, Ryan, Peck, Liam J., Peles, Elior, Pettingill, Philippa, Sanna, Maria D., Shakir, Akila, Sheridan, Joseph, Tewari, Damini, Themistocleous, Andreas C., Todd, Andrew J., Trendafilova, Teodora, Vincent, Angela, Walcher, Jan, Weir, Greg A., Werynska, Karolina, West, Steven J., Wildner, Hendrik, Zeilhofer, Hanns Ulrich   +39 more
core   +2 more sources

Engineered extracellular vesicles for precision renal therapy: Bioengineering strategies and clinical translation

Interdisciplinary Medicine, EarlyView.
Engineered extracellular vesicles (EVs) offer a versatile platform for kidney‐targeted therapy. This review summarizes bioengineering strategies, including cargo loading, surface modification, biomimetic fabrication, and biomaterial integration. We highlight translational challenges and propose future solutions to accelerate the clinical application of
Linru Shi, Bei Li, Wanzhu Liu, Haifeng Wu, Wenrong Xu, Cheng Ji, Hui Qian   +6 more
wiley   +1 more source

Dapsone induced cholangitis as a part of dapsone syndrome: a case report

BMC Gastroenterology, 2003
Background Dapsone can rarely cause a hypersensitivity reaction called dapsone syndrome, consisting of fever, hepatitis, exfoliative dermatitis, lymphadenopathy and hemolytic anemia.
Choudhuri Gourdas, Dhingra Sadhna, Kumar Ashish, Itha Srivenu   +3 more
doaj   +1 more source

Exploring the Chemical Complexity and Toxicological Behaviour of Semi‐permanent Make‐Up Pigments: A Systematic Review

Journal of Applied Toxicology, EarlyView.
ABSTRACT Semi‐permanent make‐up (SPMU), or micropigmentation, involves implanting pigments into the dermal layer of the skin for cosmetic enhancement. Unlike topical cosmetics, which are rapidly cleared from the body, SPMU pigments persist in living tissues, raising unique toxicological considerations.
T. A. N. Kaye, M. B. Komane, A. P. Manyisane, R. Manganyi   +3 more
wiley   +1 more source

Sildenafil-induced drug reaction with eosinophilia and systemic symptoms

Urology Case Reports
Drug reaction with eosinophilia and systemic symptoms (DRESS)/drug-induced hypersensitivity syndrome (DIHS) is a life-threatening, multi-organ adverse drug reaction with a mortality rate of approximately 10 %–20 %.
Amel Chabbouh, Faten Rebhi, Malek Ben Slimene, Kahena Jaber, Abderaouf Dhaoui   +4 more
doaj   +1 more source

Lamotrigine-induced hypersensitivity syndrome with histologic features of cd30+ lymphoma

Indian Journal of Dermatology, 2016
Drug rash with eosinophilia and systemic symptoms (DRESS) syndrome or drug-induced hypersensitivity syndrome (DIHS) is a severe adverse drug reaction. It can present with clinical, paraclinical, and histological findings mimicking skin and/or systemic ...
Farid Stephan, Roger Haber, Elio Kechichian, Francois Kamar   +3 more
doaj   +1 more source

Plasma Corticotropin-Releasing Factor Receptors and B7-2⁺ Extracellular Vesicles in Blood Correlate with Irritable Bowel Syndrome Disease Severity. [PDF]

, 2019
Extracellular vesicles (EVs) are composed of bilayer membranes that are released by different cell types and are present in bodily fluids, such as blood, urine, and bile. EVs are thought to play a key role in intracellular communication.
Bhargava, Aditi, Chang, Lin, Hagiwara, Shin-Ichiro, Hasdemir, Burcu, Heyman, Melvin B   +4 more
core   +1 more source

Oral PHGG ameliorates atopic dermatitis‐like dermatitis with concurrent modulation of colonic IgA and cecal microbiota: implications for the gut–skin axis

Journal of the Science of Food and Agriculture, EarlyView.
Abstract BACKGROUND Atopic dermatitis (AD) is increasingly recognized as a systemic inflammatory disorder linked to intestinal immune and microbiome dysregulation. However, whether dietary galactomannan fibers can mitigate AD through coordinated modulation of the gut–skin axis remains unexplored.
Derrick Kakooza, Hyeonjun Yu, Jonghyun Jeong, Jung Cheul Shin, Woo Jung Kim, Sung‐Kwon Moon, Hoon Kim   +6 more
wiley   +1 more source

Clinical Effect Analysis of Spinal Cord Electrical Stimulator Implantation for Diabetic Foot

Neuromodulation: Technology at the Neural Interface, EarlyView., 2021
Abstract Objective To investigate the clinical effect of spinal cord electrical stimulator implantation in the treatment of diabetic foot (DF). Materials and Methods We recruited 19 patients with DF who were admitted to Shengjing Hospital of China Medical University between January 2018 and May 2020.
Peng‐Bo Zhou, Min Bao
wiley   +1 more source

Thiotepa hyperpigmentation preceding epidermal necrosis: malignant intertrigo misdiagnosed as Stevens-Johnson syndrome-toxic epidermal necrolysis overlap [PDF]

, 2020
Thiotepa is a common alkylating agent known to precipitate cutaneous reactions consistent with toxic erythema of chemotherapy, including erythema and hyperpigmentation.
Choate, Evan A, Sarantopoulos, George P, Truong, Allison K, Worswick, Scott D   +3 more
core