Results 31 to 40 of about 112,427 (348)

Drug-induced hypersensitivity syndrome with rapid hematopoietic reconstitution during treatment for acute myeloid leukemia

Haematologica, 2008
Drug-induced hypersensitivity syndrome (DIHS) is a rare but severe life-threatening, drug-induced, systemic hypersensitivity reaction. We report two patients who developed DIHS during treatment for acute myeloid leukemia.
Hiroshi I. Suzuki, Takashi Asai, Zenshiro Tamaki, Akira Hangaishi, Shigeru Chiba, Mineo Kurokawa   +5 more
doaj   +1 more source

Safety and physiological effects of two different doses of elosulfase alfa in patients with morquio a syndrome: A randomized, double-blind, pilot study. [PDF]

, 2015
The primary treatment outcomes of a phase 2, randomized, double-blind, pilot study evaluating safety, physiological, and pharmacological effects of elosulfase alfa in patients with Morquio A syndrome are herewith presented.
Berger, Kenneth I, Burton, Barbara K, Genter, Fred, Harmatz, Paul, Jones, Simon A, Lau, Heather, Lewis, Gregory D, Mitchell, John J, Muschol, Nicole, Pastores, Gregory M, Shaywitz, Adam J, Sparkes, Rebecca, Sutton, V Reid, Tarnopolsky, Mark, Treadwell, Marsha   +14 more
core   +1 more source

Contemporary management of pain in cirrhosis: Toward precision therapy for pain

Hepatology, EarlyView., 2022
Abstract Chronic pain is highly prevalent in patients with cirrhosis and is associated with poor health‐related quality of life and poor functional status. However, there is limited guidance on appropriate pain management in this population, and pharmacologic treatment can be harmful, leading to adverse outcomes, such as gastrointestinal bleeding ...
Alexis Holman, Neehar Parikh, Dan J. Clauw, David A. Williams, Elliot B. Tapper   +4 more
wiley   +1 more source

A Case of Sublingual Ranula That Responded Successfully to Localized Injection Treatment with OK-432 after Healing from Drug Induced Hypersensitivity Syndrome

Case Reports in Dentistry, 2016
A ranula is a mucus retention cyst or pseudocyst caused by leakage of mucus from the sublingual gland and generally occurs in the oral floor. In addition, drug induced hypersensitivity syndrome (DIHS) is a rare but well-recognized serious adverse effect ...
Kunio Yoshizawa, Akinori Moroi, Shuichi Kawashiri, Koichiro Ueki   +3 more
doaj   +1 more source

Arabidopsis RecQl4A suppresses homologous recombination and modulates DNA damage responses [PDF]

, 2005
The DNA damage response and DNA recombination are two interrelated mechanisms involved in maintaining the integrity of the genome, but in plants they are poorly understood.
Bachrati, Bagherieh-Najjar, Bai, Blackburn, Bundock, Cohen, Courcelle, Cromie, De Silva, Dellaporta, Ellis, Fitzgerald, Frei, Gallego, Gallego, Gallego, Gherbi, Gray, Hanada, Hanin, Harrigan, Hartung, Henson, Imamura, Jackson, Jacques Hille, Johnson, Kitao, Krysan, Li, Lovett, Lowndes, McGlynn, McHugh, Mengiste, Michel, Mohammad B. Bagherieh-Najjar, Nakayama, Nakayama, Nugent, Onno M.H. Vries, Osborn, Pastink, Paul P. Dijkwel, Pierce, Puchta, Reiss, Riha, Riha, Rothstein, Sambrook, Seigneur, Sengupta, Sessions, Simon, Sinclair, Sladek, Sundaresan, Swoboda, Tercero, Ui, Valvekens, Watt, Wu, Yamagata   +64 more
core   +3 more sources

Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire [PDF]

, 2012
Idiosyncratic adverse drug reactions are unpredictable, dose independent and potentially life threatening; this makes them a major factor contributing to the cost and uncertainty of drug development. Clinical data suggest that many such reactions involve
A. Lucas, A. M. English, A. Sette, A. Wriston, B. J. Grant, B. Peters, C. A. F. de Oliveira, C. Oseroff, Cahalan, Chessman, Chung, D. A. Ostrov, D. F. Hunt, Day, E. Phillips, Faletto, Friesner, H. M. Grey, H. Mei, Harndahl, J. Jakoncic, J. Shabanowitz, J. Sidney, Ko, L. Shi, L. Yang, Lavergne, M. Harndahl, Mallal, Martin, Melroy, Phillips, Pichler, Rudolph, S. Buus, S. Lu, S. Mallal, S. Southwood, Shastri, Shimizu, Sidney, Sidney, Tenzer, Udeshi, Y. A. Pompeu, Yang, Yang, Yewdell   +47 more
core   +4 more sources

Severe drug hypersensitivity syndrome due to sulphasalazine in patient with rheumatoid arthritis

Reumatismo, 2011
Drug Hypersensitivity Syndrome, also known as Drug Rash with Eosinophilia and Systemic Symptoms is a severe adverse reaction characterized by clinical manifestations including fever, skin eruption, lymphoadenopathy, associated with eosinophilia ...
W. Grassi, C. Bertolazzi, L. Bugatti, E. Filippucci, M. Gutierrez   +4 more
doaj   +1 more source

Tools to improve the diagnosis and management of T-cell mediated adverse drug reactions

Frontiers in Medicine, 2022
Delayed drug T-cell immune-mediated hypersensitivity reactions have a large clinical heterogeneity varying from mild maculopapular exanthema (MPE) to severe cutaneous adverse reactions (SCARs) such as acute generalized exanthematous pustulosis (AGEP ...
Ana Maria Copaescu, Ana Maria Copaescu, Ana Maria Copaescu, Moshe Ben-Shoshan, Moshe Ben-Shoshan, Jason A. Trubiano, Jason A. Trubiano, Jason A. Trubiano, Jason A. Trubiano   +8 more
doaj   +1 more source

Hypothyroidism and nephrotic syndrome: why, when and how to treat [PDF]

, 2017
Hypothyroidism, characterised by low/normal free thyroxine (FT4) and free tri-iodothyronine (FT3) with elevated thyroid-stimulating hormone (TSH), is a well-known complication of nephrotic syndrome (NS).
Barbano, Biagio, Cianci, Rosario, Di Mario, Francesca, Gigante, Antonietta, Isidori, Andrea, Pofi, Riccardo, Rivoli, Laura, Rosato, Edoardo   +7 more
core   +1 more source

Sweet syndrome-like cutaneous drug reaction [PDF]

Anais Brasileiros de Dermatologia, 2017
: Cutaneous drug reactions are adverse reactions to medications that may present with different clinical features, ranging from localized to generalized lesions.
Lissandra Melati da Silva, Raquel de Almeida Boechat, Iale Oliveira da Hora, José Roberto Pereira Pegas   +3 more
doaj   +2 more sources