Results 21 to 30 of about 933,502 (358)
Pharmaceutical Fronts, 2022 This study aims to identify the chemical components in Sophorae Fructus, and explore the mass spectrometric cleavage rules using the UPLC-Q-TOF-MS/MS method. The main characteristic fragments of the compounds were analyzed by electrospray ionization (ESI)
Zi-Hui He +3 more
doaj +1 more source
Recent Research Advances in Small-Molecule Pan-PIM Inhibitors
Pharmaceutical Fronts, 2022 PIM kinase is consequently emerging as a promising target for cancer therapeutics and immunomodulation. PIM kinases are overexpressed in a variety of hematological malignancies and solid tumors, and their inhibition has become a strong therapeutic ...
Lei Xu +5 more
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Potential therapies against SARS-CoV-2 virus evaluated in large-scale clinical trials [PDF]
Romanian Journal of Pharmaceutical Practice, 2022 COVID-19 is a viral disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The pathogenesis of SARS-CoV-2 infection in humans manifests as mild symptoms to severe respiratory failure.
Alin-Viorel Focsa +4 more
doaj +1 more source
Pharmaceutical Fronts, 2021 A series of mono- or bis-quaternary ammonium salts derived from cinchonidine or quinine was synthesized and screened as potent phase-transfer catalysts for the reaction of aza-Michael cyclization, the key step in the synthesis of letermovir.
Liang Chen +7 more
doaj +1 more source
The Effects of Industry Sponsorship on Comparator Selection in Trial Registrations for Neuropsychiatric Conditions in Children [PDF]
, 2013 Pediatric populations continue to be understudied in clinical drug trials despite the increasing use of pharmacotherapy in children, particularly with psychotropic drugs.
Bourgeois, Florence T. +3 more
core +3 more sources
Menthol sensory qualities and smoking topography: a review of tobacco industry documents. [PDF]
, 2011 ObjectiveTo determine what the tobacco industry knew about the potential effects of menthol on smoking topography-how a person smokes a cigarette.MethodsA snowball strategy was used to systematically search the Legacy Tobacco Documents Library (http ...
McCandless, Phyra M, Yerger, Valerie B
core +2 more sources
Prevalence of tablet splitting in a Brazilian tertiary care hospital
Pharmacy Practice, 2020 Background: Although a highly common practice in hospital care, tablet splitting can cause dose variation and reduce drug stability, both of which impair drug therapy. Objective: To determine the overall prevalence of tablet splitting in hospital care
Vivianne V. Melo +6 more
doaj +1 more source
Chiral Analysis of the Key Intermediates of Tenofovir Alafenamide Fumarate
Pharmaceutical Fronts, 2023 (R)-Tenofovir phenyl ester ((R)-1) and (R)-tenofovir diphenyl ester ((R)-2) are key intermediates for the practical synthesis of tenofovir alafenamide fumarate, which is a mainstay antiretroviral for the treatment of chronic hepatitis B and HIV-1 ...
Man Li, Ting Zhou, Qing-Wen Zhang
doaj +1 more source
Synthesis and Antitumor Activity of (3-Hydroxyacrylato-O,O′) Diammineplatinum(II)
Pharmaceutical Fronts, 2021 As an indispensable part of cancer chemotherapy, platinum drugs still play an important role in cancer treatment. In this study, two platinum(II) complexes with Michael acceptor 3-hydroxyacrylic acid as the leaving group were synthesized from cis ...
Yong-Zhi Shu +6 more
doaj +1 more source