Results 41 to 50 of about 7,440,138 (398)
Pharmaceutical Fronts, 2020 Adalimumab, a full-length monoclonal antibody, is widely used as an anti-tumor necrosis factor-α (anti-TNF-α) agent. In this article, we aimed to prolong the in vivo half-life of adalimumab antigen-binding fragment (Fab) through Sortase A (SrtA)-mediated
Qing-Bin Zhang +5 more
doaj +1 more source
Pharmaceutical Fronts, 2021 A series of mono- or bis-quaternary ammonium salts derived from cinchonidine or quinine was synthesized and screened as potent phase-transfer catalysts for the reaction of aza-Michael cyclization, the key step in the synthesis of letermovir.
Liang Chen +7 more
doaj +1 more source
Using transcriptomics to guide lead optimization in drug discovery projects : lessons learned from the QSTAR project [PDF]
, 2015 The pharmaceutical industry is faced with steadily declining R&D efficiency which results in fewer drugs reaching the market despite increased investment.
Bender, Andreas +10 more
core +2 more sources
Knowledge-Driven New Drug Recommendation [PDF]
arXiv, 2022 Drug recommendation assists doctors in prescribing personalized medications to patients based on their health conditions. Existing drug recommendation solutions adopt the supervised multi-label classification setup and only work with existing drugs with sufficient prescription data from many patients.
arxiv
Making regulation responsive to commercial interests: streamlining drug industry watchdogs [PDF]
, 2002 New prescription drugs are developed and tested for quality, safety, and efficacy by the pharmaceutical industry, and little or no drug testing is conducted by governments in modern industrialised countries.
Abraham, John
core +2 more sources
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
Nature Reviews Microbiology, 2022 Despite two decades of intensified research to understand and cure tuberculosis disease, biological uncertainties remain and hamper progress. However, owing to collaborative initiatives including academia, the pharmaceutical industry and non-for-profit ...
V. Dartois, E. Rubin
semanticscholar +1 more source
Chiral Analysis of the Key Intermediates of Tenofovir Alafenamide Fumarate
Pharmaceutical Fronts, 2023 (R)-Tenofovir phenyl ester ((R)-1) and (R)-tenofovir diphenyl ester ((R)-2) are key intermediates for the practical synthesis of tenofovir alafenamide fumarate, which is a mainstay antiretroviral for the treatment of chronic hepatitis B and HIV-1 ...
Man Li, Ting Zhou, Qing-Wen Zhang
doaj +1 more source
Drugs, Industry, and Academia [PDF]
Science, 2008 This week, international academic and industry leaders, investors, and policy-makers participated in the Biotechnology Industry Organization9s International Convention in San Diego, a reminder that prospects for new drugs seem bleak. Only 17 new molecular entities were approved by the U.S.
openaire +3 more sources
The Price of Progress: Funding and Financing Alzheimer\u27s Disease Drug Development [PDF]
, 2018 Introduction Advancing research and treatment for Alzheimer\u27s disease (AD) and the search for effective treatments depend on a complex financial ecosystem involving federal, state, industry, advocacy, venture capital, and philanthropy funding ...
Cummings, Jeffrey +2 more
core +2 more sources
Application of Digital Image Processing in Drug Industry
, 2017 Digital Image Processing is a very vast field It has many applications in every field and one such application is in drug industry. Drug Industry is leading industry.
Huvaida Manzoor
semanticscholar +1 more source