Results 51 to 60 of about 7,614,121 (392)
Drugs, Industry, and Academia [PDF]
Science, 2008 This week, international academic and industry leaders, investors, and policy-makers participated in the Biotechnology Industry Organization9s International Convention in San Diego, a reminder that prospects for new drugs seem bleak. Only 17 new molecular entities were approved by the U.S.
openaire +3 more sources
Human organs-on-chips for disease modelling, drug development and personalized medicine
Nature reviews genetics, 2022 The failure of animal models to predict therapeutic responses in humans is a major problem that also brings into question their use for basic research.
D. Ingber
semanticscholar +1 more source
Menthol sensory qualities and smoking topography: a review of tobacco industry documents. [PDF]
, 2011 ObjectiveTo determine what the tobacco industry knew about the potential effects of menthol on smoking topography-how a person smokes a cigarette.MethodsA snowball strategy was used to systematically search the Legacy Tobacco Documents Library (http ...
McCandless, Phyra M, Yerger, Valerie B
core +2 more sources
Accelerating antiviral drug discovery: lessons from COVID-19
Nature reviews. Drug discovery, 2023 During the coronavirus disease 2019 (COVID-19) pandemic, a wave of rapid and collaborative drug discovery efforts took place in academia and industry, culminating in several therapeutics being discovered, approved and deployed in a 2-year time frame ...
Annette von Delft +7 more
semanticscholar +1 more source
Chiral Analysis of the Key Intermediates of Tenofovir Alafenamide Fumarate
Pharmaceutical Fronts, 2023 (R)-Tenofovir phenyl ester ((R)-1) and (R)-tenofovir diphenyl ester ((R)-2) are key intermediates for the practical synthesis of tenofovir alafenamide fumarate, which is a mainstay antiretroviral for the treatment of chronic hepatitis B and HIV-1 ...
Man Li, Ting Zhou, Qing-Wen Zhang
doaj +1 more source
Prevalence of tablet splitting in a Brazilian tertiary care hospital
Pharmacy Practice, 2020 Background: Although a highly common practice in hospital care, tablet splitting can cause dose variation and reduce drug stability, both of which impair drug therapy. Objective: To determine the overall prevalence of tablet splitting in hospital care
Vivianne V. Melo +6 more
doaj +1 more source
Synthesis and Antitumor Activity of (3-Hydroxyacrylato-O,O′) Diammineplatinum(II)
Pharmaceutical Fronts, 2021 As an indispensable part of cancer chemotherapy, platinum drugs still play an important role in cancer treatment. In this study, two platinum(II) complexes with Michael acceptor 3-hydroxyacrylic acid as the leaving group were synthesized from cis ...
Yong-Zhi Shu +6 more
doaj +1 more source
Anti-tuberculosis treatment strategies and drug development: challenges and priorities
Nature Reviews Microbiology, 2022 Despite two decades of intensified research to understand and cure tuberculosis disease, biological uncertainties remain and hamper progress. However, owing to collaborative initiatives including academia, the pharmaceutical industry and non-for-profit ...
V. Dartois, E. Rubin
semanticscholar +1 more source
Molecules, 2020 During 2019, the US Food and Drug Administration (FDA) approved 48 new drugs (38 New Chemical Entities and 10 Biologics). Although this figure is slightly lower than that registered in 2018 (59 divided between 42 New Chemical Entities and 17 Biologics ...
B. G. de la Torre, F. Albericio
semanticscholar +1 more source
Ceftiofur-loaded PHBV microparticles: A potential formulation for a long-acting antibiotic to treat animal infections [PDF]
, 2012 Indexación: Web of Science; ScieloBackground: The infectious diseases in the livestock breeding industry represent a significant drawback that generates substantial economic loss and have led to the indiscriminate use of antibiotics.
Constandil +5 more
core +1 more source