Results 81 to 90 of about 7,440,138 (398)

A comparative study of circulating tumor cell isolation and enumeration technologies in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells were spiked into donor blood to evaluate the recovery rates of the following circulating tumor cell (CTC) enrichment technologies: CellMag™, EasySep™, RosetteSep™, Parsortix® PR1, and Parsortix® Prototype systems. Each method's advantages and disadvantages are described.
Volga M Saini, Ezgi Oner, Mark P. Ward, Sinead Hurley, Brian David Henderson, Faye Lewis, Stephen P. Finn, Gerard J. Fitzmaurice, John J. O'Leary, Sharon O'Toole, Lorraine O'Driscoll, Kathy Gately   +11 more
wiley   +1 more source

Has the implementation of the TRIPS Agreement in Latin America and the Caribbean produced intellectual property legislation that favours public health?

Bulletin of the World Health Organization
OBJECTIVE: The World Trade Organization's Trade-Related Aspects of Intellectual Property Rights (TRIPS) Agreement establishes minimum standards for intellectual property rights, including patent protection for pharmaceuticals; therefore, it may make it ...
Maria Auxiliadora Oliveira, Jorge Antonio Zepeda Bermudez, Gabriela Costa Chaves, Germán Velásquez   +3 more
doaj   +1 more source

Process Study on the Enzyme-Catalyzed Preparation of Key Chiral Intermediates for Saxagliptin

Pharmaceutical Fronts, 2022
Saxagliptin is a therapeutic drug for diabetes. The key synthesis process of the drug involves catalyzing 2-(3-hydroxy-1-adamantyl)-2-oxoacetic acid (A) into (S)-3-hydroxyadamantane glycine (B), during which enzymes phenylalanine dehydrogenase mutant ...
Shan-Shan Li, Zong-Qing Huang, Hao-Ju Hua, Jian-Guang Lu, Wen-Jie Zhao, Jun Feng   +5 more
doaj   +1 more source

On‐treatment dynamics of circulating extracellular vesicles in the first‐line setting of patients with advanced non‐small cell lung cancer: the LEXOVE prospective study

Molecular Oncology, EarlyView.
The LEXOVE prospective study evaluated plasma cell‐free extracellular vesicle (cfEV) dynamics using Bradford assay and dynamic light scattering in metastatic non‐small cell lung cancer patients undergoing first‐line treatments, correlating a ∆cfEV < 20% with improved median progression‐free survival in responders versus non‐responders.
Valerio Gristina, Viviana Bazan, Nadia Barraco, Simona Taverna, Mauro Manno, Samuele Raccosta, Anna Paola Carreca, Marco Bono, Tancredi Didier Bazan Russo, Francesco Pepe, Pasquale Pisapia, Lorena Incorvaia, Giuseppe Badalamenti, Giancarlo Troncone, Umberto Malapelle, Daniele Santini, Antonio Russo, Antonio Galvano   +17 more
wiley   +1 more source

Using mathematical models of heart cells to assess the safety of new pharmaceutical drugs [PDF]

Mirams, G.R. (2025). Using Mathematical Models of Heart Cells to Assess the Safety of New Pharmaceutical Drugs. In: Aston, P.J. (eds) More UK Success Stories in Industrial Mathematics. Mathematics in Industry, vol 42. Springer, Cham
Many drugs have been withdrawn from the market worldwide, at a cost of billions of dollars, because of patient fatalities due to them unexpectedly disturbing heart rhythm. Even drugs for ailments as mild as hay fever have been withdrawn due to an unacceptable increase in risk of these heart rhythm disturbances.
arxiv   +1 more source

Cellular liquid biopsy provides unique chances for disease monitoring, preclinical model generation and therapy adjustment in rare salivary gland cancer patients

Molecular Oncology, EarlyView.
We quantified and cultured circulating tumor cells (CTCs) of 62 patients with various cancer types and generated CTC‐derived tumoroid models from two salivary gland cancer patients. Cellular liquid biopsy‐derived information enabled molecular genetic assessment of systemic disease heterogeneity and functional testing for therapy selection in both ...
Nataša Stojanović Gužvić, Florian Lüke, Steffi Treitschke, Andrea Coluccio, Martin Hoffmann, Giancarlo Feliciello, Adithi Ravikumar Varadarajan, Xin Lu, Kathrin Weidele, Catherine Botteron, Silvia Materna–Reichelt, Felix Keil, Katja Evert, Florian Weber, Thomas Schamberger, Michael Althammer, Jirka Grosse, Dirk Hellwig, Christian Schulz, Stephan Seitz, Peter Ugocsai, Anke Schlenska‐Lange, Roman Mayr, Ulrich Kaiser, Wolfgang Dietmaier, Bernhard Polzer, Jens Warfsmann, Kamran Honarnejad, Tobias Pukrop, Daniel Heudobler, Christoph A. Klein, Christian Werno   +31 more
wiley   +1 more source

Farmacologia no século XX: a ciência dos medicamentos a partir da análise do livro de Goodman e Gilman Pharmacology in the twentieth century: the science of drugs through the analysis of Goodman and Gilman's textbook

História, Ciências, Saúde: Manguinhos, 2013
Analisa a apresentação da farmacologia como ciência a partir do livro-texto de Louis Goodman e Alfred Gilman reeditado e reimpresso inúmeras vezes entre 1941 e 2006. Nas primeiras edições, a farmacologia é caracterizada
Silvia Cardoso Bittencourt, Sandra Caponi, Sônia Maluf   +2 more
doaj  

Disposal Management in Biological-Pharmaceutical Centers of Alborz Province, Iran

تحقیقات نظام سلامت, 2021
Background: Wastewater is highly sensitive in pharmaceutical industries due to its various microbial and chemical pollutions, and its proper management is of special importance.
Hassan Mardani
doaj  

Evaluation Of The Performance Of Companies Operating In The Pharmaceutical Sector For Reverse Logistics Applications With TOPSIS and MOORA Methods

Journal of Transportation and Logistics, 2019
Reverse logistics activities, which are the process of taking products back to the supply chain point for disposal and recycling are quite expensive and complex.
Batuhan Kocaoğlu, Aykut Küçük
doaj   +1 more source

What's Good for Washington: Fair Prescription Drug Pricing and the Biotechnology Industry [PDF]

, 2003
The rising cost of prescription drugs is consuming an ever-larger portion of limited funds for basic health care and other important services in Washington state.
Rebecca Kavoussi
core