Results 11 to 20 of about 11,447,845 (407)

Pharmacokinetic, Pharmacodynamic, and Drug-Interaction Profile of Remdesivir, a SARS-CoV-2 Replication Inhibitor

Clinical Pharmacokinetics, 2021
Remdesivir (RDV, Veklury®) is a once-daily, nucleoside ribonucleic acid polymerase inhibitor of severe acute respiratory syndrome coronavirus 2 replication.
R. Humeniuk, A. Mathias, B. Kirby, J. Lutz, H. Cao, A. Osinusi, D. Babusis, D. Porter, Xuelian Wei, J. Ling, Y. S. Reddy, P. German   +11 more
semanticscholar   +1 more source

DDInter: an online drug–drug interaction database towards improving clinical decision-making and patient safety

Nucleic Acids Res., 2021
Drug-drug interaction (DDI) can trigger many adverse effects in patients and has emerged as a threat to medicine and public health. Despite the continuous information accumulation of clinically significant DDIs, there are few open-access knowledge ...
Guoli Xiong, Zhi-Jiang Yang, Jiacai Yi, Ningning Wang, Lei Wang, Huimin Zhu, Chengkun Wu, Aiping Lu, Xiang Chen, Shao Liu, Tingjun Hou, Dongsheng Cao   +11 more
semanticscholar   +1 more source

Enhancing Drug-Drug Interaction Prediction Using Deep Attention Neural Networks

bioRxiv, 2021
Drug-drug interactions are one of the main concerns in drug discovery. Accurate prediction of drug-drug interactions plays a key role in increasing the efficiency of drug research and safety when multiple drugs are c o-prescribed.
Shichao Liu, Yang Zhang, Yuxin Cui, Yang Qiu, Yifan Deng, Wen Zhang, Zhongfei Zhang   +6 more
semanticscholar   +1 more source

MDNN: A Multimodal Deep Neural Network for Predicting Drug-Drug Interaction Events

International Joint Conference on Artificial Intelligence, 2021
The interaction of multiple drugs could lead to serious events, which causes injuries and huge medical costs. Accurate prediction of drug-drug interaction (DDI) events can help clinicians make effective decisions and establish appropriate therapy ...
Tengfei Lyu, Jianliang Gao, Ling Tian, Zhao Li, Peng Zhang, Ji Zhang   +5 more
semanticscholar   +1 more source

Multi-view Graph Contrastive Representation Learning for Drug-Drug Interaction Prediction [PDF]

The Web Conference, 2020
Potential Drug-Drug Interactions (DDI) occur while treating complex or co-existing diseases with drug combinations, which may cause changes in drugs’ pharmacological activity.
Yingheng Wang, Yaosen Min, Xin Chen, Ji Wu   +3 more
semanticscholar   +1 more source

Variability in In Vitro OATP1B1/1B3 Inhibition Data: Impact of Incubation Conditions on Variability and Subsequent Drug Interaction Predictions

Clinical and Translational Science, 2020
As the research into the organic anion transporting polypeptides (OATPs) continues to grow, it is important to ensure that the data generated are accurate and reproducible.
Savannah J. McFeely, Tasha K. Ritchie, Isabelle Ragueneau‐Majlessi   +2 more
doaj   +1 more source

Enhancing Dissolution and Oral Bioavailability of Ursodeoxycholic Acid with a Spray-Dried pH-Modified Extended Release Formulation

Pharmaceutics, 2022
Ursodeoxycholate (UDCA) has low oral bioavailability and pH-dependent solubility and permeability. Thus, we developed a pH-modified extended-release formulation of UDCA using Na2CO3 as the alkalizing agent and hydroxypropyl methylcellulose (HPMC) as the ...
Jaehyeok Lee, Chul Haeng Lee, Jong-Geon Lee, So Yeon Jeon, Min-Koo Choi, Im-Sook Song   +5 more
doaj   +1 more source

Recent Advances in Doxorubicin Formulation to Enhance Pharmacokinetics and Tumor Targeting

Pharmaceuticals, 2023
Doxorubicin (DOX), a widely used drug in cancer chemotherapy, induces cell death via multiple intracellular interactions, generating reactive oxygen species and DNA-adducted configurations that induce apoptosis, topoisomerase II inhibition, and histone ...
Jihoon Lee, Min-Koo Choi, Im-Sook Song
doaj   +1 more source

A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing

Nature, 2020
A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals
D. Gordon, Gwendolyn M. Jang, Mehdi Bouhaddou, Jiewei Xu, K. Obernier, K. White, Matthew J. O’Meara, V. Rezelj, Jeffrey Z. Guo, D. Swaney, Tia A. Tummino, Ruth Hüttenhain, Robyn M. Kaake, Alicia L. Richards, B. Tutuncuoglu, Helene Foussard, J. Batra, Kelsey M. Haas, Mayank Modak, Minkyu Kim, Paige Haas, Benjamin J. Polacco, Hannes Braberg, Jacqueline M. Fabius, Manon Eckhardt, Margaret Soucheray, M. J. Bennett, Merve Cakir, Michael J. McGregor, Qiongyu Li, Bjoern Meyer, F. Roesch, T. Vallet, Alice Mac Kain, Lisa Miorin, Elena Moreno, Zun Zar Chi Naing, Yuan Zhou, S. Peng, Ying Shi, Ziyang Zhang, W. Shen, I. T. Kirby, James E. Melnyk, John S. Chorba, Kevin Lou, Shizhong A. Dai, Inigo Barrio-Hernandez, Danish Memon, Claudia Hernandez-Armenta, Jiankun Lyu, Christopher J. P. Mathy, Tina Perica, K. B. Pilla, Sai J. Ganesan, Daniel J. Saltzberg, R. Rakesh, Xi Liu, S. Rosenthal, Lorenzo Calviello, S. Venkataramanan, José M Liboy-Lugo, Yizhu Lin, Xi-Ping Huang, Yongfeng Liu, S. Wankowicz, M. Bohn, M. Safari, Fatima S. Ugur, Cassandra Koh, Nastaran Sadat Savar, Q. D. Tran, Djoshkun Shengjuler, S. Fletcher, M. C. O’Neal, Yiming Cai, Jason C. J. Chang, D. Broadhurst, Saker Klippsten, P. P. Sharp, Nicole A. Wenzell, Duygu Kuzuoglu-Ozturk, Hao-Yuan Wang, R. Trenker, Janet M. Young, D. A. Cavero, J. Hiatt, Theodore L. Roth, Ujjwal Rathore, Advait Subramanian, Julia Noack, Mathieu Hubert, R. Stroud, A. Frankel, O. Rosenberg, K. Verba, D. Agard, M. Ott, M. Emerman, N. Jura, M. von Zastrow, E. Verdin, A. Ashworth, O. Schwartz, C. d’Enfert, Shaeri Mukherjee, Matt Jacobson, Harmit S. Malik, D. Fujimori, T. Ideker, C. Craik, S. Floor, J. Fraser, J. Gross, A. Sali, B. Roth, D. Ruggero, J. Taunton, T. Kortemme, P. Beltrão, M. Vignuzzi, A. García-Sastre, K. Shokat, B. Shoichet, N. Krogan   +124 more
semanticscholar   +1 more source

Chorismate synthase mediates cerebral malaria pathogenesis by eliciting salicylic acid-dependent autophagy response in parasite

Biology Open, 2020
Cerebral malaria caused by Plasmodium falciparum is the severest form of the disease resulting in the morbidity of a huge number of people worldwide. Development of effective curatives is essential in order to overcome the fatality of cerebral malaria ...
Malabika Chakrabarti, Deepika Kannan, Akshay Munjal, Hadi Hasan Choudhary, Satish Mishra, Shailja Singh   +5 more
doaj   +1 more source