Results 41 to 50 of about 471,442 (349)
Open Access Surgery, 2022 Seyoum Hailu Department of Anesthesiology, Dilla University, Dilla, EthiopiaCorrespondence: Seyoum Hailu, Email seyoumhailu44@gmail.comBackground: The practice of anesthesiology needs an anesthetist to administer multiple potent drugs with high accuracy ...
Hailu S
doaj
Разработка и регистрация лекарственных средств, 2021 Introduction. This publication describes the design and implementation sequence of technological procedures for labeling immunobiological medicinal products produced by the FGHI RusRAPI "Microbe" of the Rospotrebnadzor.
A. V. Komissarov +9 more
doaj +1 more source
The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein [PDF]
, 2004 Structural evidence has demonstrated that P-glycoprotein (P-gp) undergoes considerable conformational changes during catalysis, and these alterations are important in drug interaction. Knowledge of which regions in P-gp undergo conformational alterations
al-Shawi +56 more
core +1 more source
GPCR structural characterization by NMR spectroscopy in solution
Acta Biochimica et Biophysica Sinica, 2022 In the human proteome, 826 G-protein-coupled receptors (GPCRs) interact with extracellular stimuli to initiate cascades of intracellular signaling. Determining conformational dynamics and intermolecular interactions are key to understand GPCR function as
Yang Lingyun +2 more
doaj +1 more source
Label-free drug discovery [PDF]
Frontiers in Pharmacology, 2014 Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro. Given that target-based discovery has not transformed the industry, phenotypic screen that identifies drugs based on a specific phenotype of cells, tissues, or animals has gained renewed ...
openaire +4 more sources
Fine-Tuning BERT for Automatic ADME Semantic Labeling in FDA Drug Labeling to Enhance Product-Specific Guidance Assessment [PDF]
arXiv, 2022 Product-specific guidances (PSGs) recommended by the United States Food and Drug Administration (FDA) are instrumental to promote and guide generic drug product development. To assess a PSG, the FDA assessor needs to take extensive time and effort to manually retrieve supportive drug information of absorption, distribution, metabolism, and excretion ...
arxiv
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Heter-LP: A heterogeneous label propagation algorithm and its application in drug repositioning [PDF]
, 2016 Drug repositioning offers an effective solution to drug discovery, saving both time and resources by finding new indications for existing drugs. Typically, a drug takes effect via its protein targets in the cell. As a result, it is necessary for drug development studies to conduct an investigation into the interrelationships of drugs, protein targets ...
arxiv +1 more source
Dynamic enhancement of drug product labels to support drug safety, efficacy, and effectiveness [PDF]
, 2013 Out-of-date or incomplete drug product labeling information may increase the risk of otherwise preventable adverse drug events. In recognition of these concerns, the United States Federal Drug Administration (FDA) requires drug product labels to include ...
Boyce, Richard D +7 more
core +4 more sources
FEBS Letters, EarlyView.The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet +4 more
wiley +1 more source