Results 41 to 50 of about 454,627 (348)

Patient-reported outcomes labeling for oncology drugs: Multidisciplinary perspectives on current status and future directions

Frontiers in Pharmacology, 2022
Introduction: Regulatory agencies encourage the incorporation of the patient voices throughout clinical drug development. Patient-Reported Outcomes (PROs) offer one way of doing this and their use has markedly increased in many therapeutic areas ...
David Cella, Chieh-I Chen, Ruben G. W. Quek, Ainhoa Uribarren, Matthew Reaney, Vera Mastey, Deborah Collyar, Olivier Chassany, Olivier Chassany   +8 more
doaj   +1 more source

Challenges and Opportunities to Updating Prescribing Information for Longstanding Oncology Drugs. [PDF]

, 2019
A number of important drugs used to treat cancer-many of which serve as the backbone of modern chemotherapy regimens-have outdated prescribing information in their drug labeling.
Balogh, Erin P, Bindman, Andrew B, Eckhardt, S Gail, Halabi, Susan, Harvey, R Donald, Jaiyesimi, Ishmael, Miksad, Rebecca, Moses, Harold L, Nass, Sharyl J, Schilsky, Richard L, Sun, Steven, Torrente, Josephine M, Warren, Katherine E   +12 more
core   +2 more sources

Role of dorsomedial striatum neuronal ensembles in incubation of methamphetamine craving after voluntary abstinence [PDF]

, 2017
We recently developed a rat model of incubation of methamphetamine craving after choice-based voluntary abstinence. Here, we studied the role of dorsolateral striatum (DLS) and dorsomedial striatum (DMS) in this incubation.
Bossert, Jennifer M., CAPRIOLI, DANIELE, Hope, Bruce T., Shaham, Yavin, Venniro, Marco, Warren, Brandon L., Zhang, Michelle   +6 more
core   +2 more sources

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Packaging and Labeling of Pharmaceutical Products Obtained from the Internet

Journal of Medical Internet Research, 2011
BackgroundFor patients, the prescription container label may be the only source of instructions on how to take their medicines. In the United States, the legal requirements for a prescription label are set by federal law and state statutes. The container
Veronin, Michael
doaj   +1 more source

Label-free drug discovery [PDF]

Frontiers in Pharmacology, 2014
Current drug discovery is dominated by label-dependent molecular approaches, which screen drugs in the context of a predefined and target-based hypothesis in vitro. Given that target-based discovery has not transformed the industry, phenotypic screen that identifies drugs based on a specific phenotype of cells, tissues, or animals has gained renewed ...
openaire   +3 more sources

Teaching of Critical Analysis of Drug Advertisements to Medical Students [PDF]

, 2011
Background: Medical practitioners utilize drug promotional materials from pharmaceutical companies as a major source of information especially in developing countries.
Adiga, S, Bairy, KL, Chogtu, B, Nayak, V
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Level of Evidence Associated with FDA Safety Communications with Drug Labeling Changes: 2010-2014

INNOVATIONS in Pharmacy, 2017
Purpose: Approximately 800,000 safety reports are submitted to the FDA annually, however, only significant issues generate drug safety communications (DSC). The purpose of this study was to determine the type of clinical evidence used to warrant a change
Benjamin Hixon, Joseph M. Lowrey, Lindsay N Hume, Katelynn Mayberry, Maisha Kelly Freeman   +4 more
doaj   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source