Results 1 to 10 of about 6,868,569 (338)
Cytochrome P450 Enzymes and Drug Metabolism in Humans
International Journal of Molecular Sciences, 2021 Human cytochrome P450 (CYP) enzymes, as membrane-bound hemoproteins, play important roles in the detoxification of drugs, cellular metabolism, and homeostasis. In humans, almost 80% of oxidative metabolism and approximately 50% of the overall elimination
Mingzhe Zhao +10 more
semanticscholar +1 more source
Human Gut Microbiota and Drug Metabolism
Microbial Ecology, 2022 The efficacy of drugs widely varies in individuals, and the gut microbiota plays an important role in this variability. The commensal microbiota living in the human gut encodes several enzymes that chemically modify systemic and orally administered drugs,
Archana Pant +3 more
semanticscholar +1 more source
Drug metabolism and drug transport of the 100 most prescribed oral drugs
Basic & Clinical Pharmacology & Toxicology, 2022 Safe and effective use of drugs requires an understanding of metabolism and transport. We identified the 100 most prescribed drugs in six countries and conducted a literature search on in vitro data to assess contribution of Phase I and II enzymes and ...
D. B. Iversen +4 more
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2023 Daprodustat is an oral small molecule hypoxia‐inducible factor (HIF) prolyl hydroxylase inhibitor (PHI) approved in Japan and the United States for the treatment of anemia associated with chronic kidney disease.
Guoying Tai +8 more
doaj +1 more source
Exploring Drug Metabolism by the Gut Microbiota: Modes of Metabolism and Experimental Approaches
Drug Metabolism And Disposition, 2021 Increasing evidence uncovers the involvement of gut microbiota in the metabolism of numerous pharmaceutical drugs. The human gut microbiome harbors 10–100 trillion symbiotic gut microbial bacteria that use drugs as substrates for enzymatic processes to ...
Pooja Dhurjad +3 more
semanticscholar +1 more source
Clinical and Translational Science, 2021 The impact of organic anion‐transporting polypeptide (OATP) inhibition on systemic and liver exposures of three OATP substrates was investigated in cynomolgus monkeys.
Yaofeng Cheng +4 more
doaj +1 more source
Drug metabolism in the lungs: opportunities for optimising inhaled medicines
Expert Opinion on Drug Metabolism & Toxicology, 2021 Introduction The lungs possess many xenobiotic metabolizing enzymes which influence the pharmacokinetics and safety of inhaled medicines. Anticipating metabolism in the lungs provides an opportunity to optimize new inhaled medicines and overcome ...
Zachary Enlo-Scott +3 more
semanticscholar +1 more source
Personalized Mapping of Drug Metabolism by the Human Gut Microbiome.
Cell, 2020 The human gut microbiome harbors hundreds of bacterial species with diverse biochemical capabilities. Dozens of drugs have been shown to be metabolized by single isolates from the gut microbiome, but the extent of this phenomenon is rarely explored in ...
Bahar Javdan +8 more
semanticscholar +1 more source
Pharmacology Research & Perspectives, 2020 In clinical pharmacology, the free drug hypothesis has been widely applied in the interpretation of the relationship between pharmacokinetics and pharmacodynamics (PK/PD).
Chun Chen +21 more
doaj +1 more source
Cell Death Discovery, 2022 As the modulation of serine/arginine-rich splicing factor 3 (SRSF3) may be therapeutically beneficial to colorectal cancer (CRC) treatment, the identification of novel SRSF3 inhibitors is highly anticipated. However, pharmaceutical agents targeting SRSF3
Yawen Zhang +14 more
doaj +1 more source