Results 81 to 90 of about 249,494 (353)

Substance misuse assessment in mental health services: the importance of professional curiosity [PDF]

, 2017
Co-morbidity of mental health and substance misuse problems (or "Dual Diagnosis") is highly prevalent in mental health and drug treatment services. The parallel approach, where the two conditions are treated at the same time in separate services, is the ...
Milani, Raffaella Margherita, University of West London   +1 more
core  

TP53BP2 Promotes Placental Autophagy and Preeclampsia via G9a and DNMT1 Cooperatively Modulating E2F1

Advanced Science, EarlyView.
G9a, and DNA Methyltransferase1 (DNMT1) cooperatively modulates E2F1 on the promoter of tumor suppressor p53‐binding protein 2 (TP53BP2) increased autophagy in preeclampsia. TP53BP2 promotes autophagy in trophoblasts through DNA methylation and H3K9me2‐mediated transcriptional regulation.
Nan Jiang, Shaoju Jin, Shaoying Wen, Wen Zeng, Chen Wang, Jingyu Wang, Qingyun Song, Guizhong Li, Pengzhi Yin, Yuhui Liao, Yuee Chai, Huiping Zhang, Shengchao Ma   +12 more
wiley   +1 more source

Prevalence and correlates of prescription drug diversion and misuse among people living with HIV in the eThekwini district, KwaZulu-Natal, South Africa.

PLoS ONE, 2020
BackgroundPrescription drug diversion, and misuse has increased over the past decade and is notably in high-income-countries and significantly contributes to the opioid epidemic.
Buyisile Chibi, Nonhlanhla Yende-Zuma, Tivani P Mashamba-Thompson   +2 more
doaj   +1 more source

How to Misuse Drugs

Curationis, 1978
Most of us, during our training, are taught about the actions of drugs and their side-effects, but very few of us are taught how to misuse drugs. However, this is an art that seems to be acquired through practice in handling drugs, by various members of the medical and nursing professions, as well as by the general population. The purpose of this paper
openaire   +4 more sources

A Glucose‐Responsive Intelligent Antibacterial and Oxygen‐Producing Hydrogel Promotes the Healing of Diabetic Wounds by Regulating Cellular Heterogeneity

Advanced Science, EarlyView.
We have developed a glucose‐triggered on‐demand drug delivery CF‐CPGaMPN hydrogel based on borate ester bonds. It inactivates microbes, releases oxygen, and enables on‐demand drug release in high‐glucose environments to promote healing of diabetic wounds. Single‐cell sequencing reveals that the CF‐CPGaMPN hydrogel significantly alleviates dysfunctional
Manxuan Liu, Zhongcheng Li, Qian Ren, Ziqian Lu, Yubing Zhang, Yili Guo, Ruomeng Li, Die Hu, Linglin Zhang   +8 more
wiley   +1 more source

The disappearance of the "revolving door" patient in Scottish general practice: successful policies [PDF]

, 2012
<b>Background</b> We describe the health of "revolving door" patients in general practice in Scotland, estimate changes in their number over the timescale of the study, and explore reasons for changes, particularly related to NHS and ...
Andrea E Williamson, B Charlin, CA O'Donnell, D O'Reilly, J Greene, J Munro, JCM Gillies, JL Geller, K Charmaz, Kenneth Mullen, Paul CD Johnson, Philip Wilson, RR Donnelley   +12 more
core   +4 more sources

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

Advanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang, Bohao Liu, Xingzhuo Zhu, Deqian Qiao, Sizhe Chen, Xiaoyan Zeng, Qingqing Yang, Zihuan Wei, Yinjuan Huang, Jizhao Wang, Guangjian Zhang, Qiuyu Gong   +11 more
wiley   +1 more source

Conversion of Transplanted Mature Hepatocytes into Afp+ Reprogrammed Cells for Liver Regeneration After Injury

Advanced Science, EarlyView.
Donor‐derived tdTomato+ mature hepatocytes were FACS‐isolated and transplanted into Fah−/− host mice. During regeneration, these cells convert into proliferative, unipotent Afp+ rHeps. Their plasticity is governed by a PPARγ/AFP‐dependent metabolic switch, segregating into pro‐proliferative Afplow and pro‐survival Afphigh subpopulations.
Ting Fang, Chao Yang, Hua Qiu, Yuan Du, Xicheng Wang, Yuting Li, Mingyang Xu, Changcheng Liu, Xiuhua Li, Na Guo, Jun Shi, Wencheng Zhang, Zhiying He   +12 more
wiley   +1 more source

Focus on ‘Psychiatry and Addiction: A Multi-Faceted Issue’

Brain Sciences
The reconceptualization of addiction as a neurobiological disease has gained significant traction over recent decades, informed by advances in neuropharmacological and neuroimaging research [...]
Fabrizio Schifano, Giovanni Martinotti, Norbert Scherbaum   +2 more
doaj   +1 more source

SMart Nanoparticle–Hydrogel Hybrid System for Synergistic Eradication of Infection and Promotion of Wound Healing

Advanced Science, EarlyView.
The integrated system, comprising bacterial‐targeted photothermal nanoparticles (Fe2O3‐CS@RBP) and multifunctional hydrogels (PAOC‐3@BA) modules, achieves rapid wound healing within one week. This work introduces a smart therapeutic platform that integrates bacterial targeting, self‐regulating photothermal therapy, tissue adhesion, and stimulus ...
Hongping Wan, Huirong Tan, Xinghong Zhao
wiley   +1 more source