Results 61 to 70 of about 251,619 (354)

Novel Synthetic Opioids (NSOs) and Their Evolving Crisis: Utilising NPSfinder^® as a Real-Time Predictive Tool

Pharmaceuticals
Background/Objectives: The rapidly evolving crisis of Novel Synthetic Opioids (NSOs) poses a serious and growing threat for global public health. NSOs include prescription/non-prescription opioids (fentanyl, non-fentanyl analogues), herbal derivatives ...
Elena Deligianni, Davide Arillotta, Alessandro Vento, John Martin Corkery, Georgios Papazisis, Antonis Goulas, Lisa Lione, Fabrizio Schifano   +7 more
doaj   +1 more source

Restriction of Individual Branched‐Chain Amino Acids has Distinct Effects on the Development and Progression of Alzheimer's Disease in 3xTg Mice

Advanced Science, EarlyView.
Protein restriction (PR) slows Alzheimer's disease (AD) in mice, and other benefits of PR are due to decreased branched‐chain amino acids (BCAAs). We show that restricting any BCAA has benefits, with sex‐ and BCAA‐specific impacts on pathology, molecular signaling, and cognition.
Reji Babygirija, Cara L. Green, Michelle M. Sonsalla, Izabelle Marie F. Le, Fan Xiao, Sarah Yandell, Mariah F. Calubag, Michaela E. Trautman, Anna Tobon, Ryan Matoska, Chung‐Yang Yeh, Charles I. Opara, Isaac Grunow, Diana Vertein, Sophia Schlorf, Bailey A. Knopf, Michael J. Rigby, David A. Harris, Mark P. Keller, Alan D. Attie, Luigi Puglielli, Cholsoon Jang, Dudley W. Lamming   +22 more
wiley   +1 more source

The international development of the ‘Social Norms’ approach to drug education and prevention [PDF]

, 2010
Binge drinking has sparked considerable interest and concern. However despite this interest little is known about the lay understanding of binge drinking and whether there are differences in understanding by gender, age and level of deprivation.
Bewick, B., Hughes, C., McAlaney, John
core   +1 more source

PVNCRF Neurons Regulate Migraine‐Like Allodynia by Activating CRFR2 on Spinal Trigeminal Caudalis Glutamatergic Neurons

Advanced Science, EarlyView.
Paraventricular CRF neurons in the hypothalamus project to glutamatergic neurons of the spinal trigeminal caudal nucleus, enhancing neuronal activation and CRFR2 signaling. This pathway increases CRF release and excitatory drive, promoting central sensitization and migraine‐related behaviors. Targeting the PVN–SP5C circuit provides a potential strategy
Jiang Bian, Xiao‐Long Wang, Li Yin, Wei Wei, Xue Li, Yao Ge, Zhao‐Xia Xiang, Na Tian, Li‐Juan Chen, Ming‐Wei Ma, Xia Zhang, Xu Jing, Mei‐Yun Wang, Xu‐Feng Xu   +13 more
wiley   +1 more source

Statistics on misuse of drugs have been misused

BMJ, 1998
EDITOR —The government's anti-drugs strategy places great emphasis on reducing drug related crime.1 Part of its concern is based on evidence of high drug use among offenders and the assumption that crime is driven by the need to finance drug use and may be prevented if problem drug users are diverted into treatment. The white paper reports that “latest
G V, Stimson, M, Hickman, P J, Turnbull
openaire   +3 more sources

Synergistic Sunlight‐Activated Photodynamic and Near‐Infrared‐Induced Mild Photothermal Therapy for Infected Wound Healing Using Functionalized Nano‐Bi2WO6 Composites

Advanced Science, EarlyView.
This work proposes a multifunctional Bi2WO6:Yb,Er@CuS@CS nanocomposite that integrates photodynamic therapy (PDT), near‐infrared‐triggered photothermal therapy (PTT), and Cu2+ release for infected wound repair. The nanocomposite demonstrates enhanced antibacterial efficacy via combined PDT, PTT, and Cu2+ release, effective immunomodulatory by mild ...
Yihao Sun, Liangrui He, Zhijun Shen, Yuxin Zhang, Yizhang Tang, Xujiang Yu, Jisi Zheng, Moran Huang, Wanwan Li, Lei Wang   +9 more
wiley   +1 more source

Prevalence and correlates of the misuse of z-drugs and benzodiazepines in the National Survey on Drug Use and Health

Frontiers in Psychiatry, 2023
BackgroundBenzodiazepines and non-benzodiazepine hypnotics (z-drugs) are commonly prescribed for their anxiolytic and hypnotic properties, though they can also be misused.
R. Kathryn McHugh, R. Kathryn McHugh, Victoria R. Votaw, Victoria R. Votaw, Emma W. Trapani, Megan D. McCarthy   +5 more
doaj   +1 more source

The family drug & alcohol court (FDAC) evaluation project [PDF]

, 2011
This report presents the findings from the evaluation of the first pilot Family Drug and Alcohol Court (FDAC) in Britain. FDAC is a new approach to care proceedings, in cases where parental substance misuse is a key element in the local authority ...
Alrouh, B, Harwin, J, Matias, C, Momenian-Schneider, S, Pokhrel, S, Ryan, M, Tunnard, J   +6 more
core  

A Chirality‐Converted Bacteriolytic Dodecapeptide Regulates Vibrio‐Induced Polymicrobial Infection and Ameliorates Invasion‐Associated Gut Microbiota Disequilibrium

Advanced Science, EarlyView.
Multidrug‐resistant Vibrio infections are rising rapidly and threaten coastal populations worldwide. This study introduces D‐zp37, a chirality‐engineered antimicrobial peptide with exceptional potency against resistant Vibrio species. D‐zp37 kills planktonic cells, blocks mixed‐species biofilms, disrupts essential bacterial stress responses, and shows ...
Ping Zeng, Qipeng Cheng, Xiaoxu Zhang, Honglan Wang, Jinghan Zhang, Xinyi Ding, Pengfei Zhang, Lanhua Yi, Kwok‐Yin Wong, Kin‐Fai Chan, Sheng Chen, Sharon Shui Yee Leung   +11 more
wiley   +1 more source

Strong Support For Sununu, Drugs Remain Most Important Problem Facing NH 5/9/17 [PDF]

, 2017
Governor Chris Sununu enjoys bipartisan approval of his job performance as well as increasing personal favorability among New Hampshire adults. A strong majority continue to believe overall the state is headed in the right direction, but for the first ...
Survey Center, UNH
core   +1 more source