Results 71 to 80 of about 76,365 (263)

COVID-19: The Hidden Impact on Mental Health and Drug Addiction

Frontiers in Psychiatry, 2020
Stefania Chiappini, Amira Guirguis, Amira Guirguis, Ann John, John Martin Corkery, Fabrizio Schifano   +5 more
doaj   +1 more source

Association Between Opioid Use and Emergency Department Visits for Spine-Related Disorders

Journal of Pain Research
Chijioke Okeke,1,2 Godwin Okoye,3 J Douglas Thornton1,2 1The Prescription Drug Misuse Education and Research (PREMIER) Center, College of Pharmacy, University of Houston, Houston, TX, USA; 2Department of Pharmaceutical Health Outcomes and Policy, College
Okeke C, Okoye G, Thornton JD
doaj  

Perioperative Intravenous Dexamethasone Improves Pain and Functional Outcomes After Arthroscopic Rotator Cuff Repair

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the effect of perioperative dexamethasone on patient‐reported pain, functional outcomes, and minimal clinically important difference (MCID) achievement following arthroscopic rotator cuff repair. Methods Patients who underwent rotator cuff repair between 2013 and 2023 were identified and divided into groups.
Trevor D. Wolterink, Germain Craddock, Joshua P. Castle, Michael A. Gaudiani, Chimdindu Obinero, Alexander S. Jurayj, Christian A. Freitag, Nathan Y. Li, Jared Mahylis, Stephanie J. Muh   +9 more
wiley   +1 more source

Characterising incident opioid use among incident users of prescription sedative hypnotics: A national cohort study

BMJ Open
Objective To evaluate co-prescribing of sedatives hypnotics and opioids.Design Retrospective study evaluating the association of patient characteristics and comorbidities with coprescribing.Setting and participants Using the national Merative MarketScan ...
Hui Zhao, Harshil Patel, James Douglas Thornton, Eric Schaefer, Chan Shen, Douglas Leslie, Tyler Varisco, Mina Shrestha, Matthew Wanat, Randa Al Saadi   +9 more
doaj   +1 more source

Metabolic fate of drugs of abuse and new psychoactive substances: A pilot study on a novel workflow using a zebrafish embryo model combined with human microdosing

British Journal of Clinical Pharmacology, EarlyView.
Aim The aim of this study was to develop a novel workflow to identify human urine biomarkers for drugs of abuse and new psychoactive substances. Metabolites of amphetamine, cocaine, LSD, MDMA, methamphetamine, THC, MDMB‐CHMICA, and MDPPP were first identified in a zebrafish embryo (ZE) metabolism study followed by comparison to most abundant human ...
Simon K. Wellenberg, Tanja M. Gampfer, Lea Wagmann, Philip Schippers, Jennifer Herrmann, Rolf Müller, Folker Westphal, Markus R. Meyer   +7 more
wiley   +1 more source

Tolazoline, an alpha-adrenergic antagonist, may also block xylazine at off-target sites as inferred from molecular docking

Frontiers in Chemical Biology
Xylazine, a non-opioid α2-adrenoceptor agonist, is increasingly implicated in misuse and opioid-adulterated overdoses. Tolazoline, a non-selective α-adrenergic antagonist, is widely used in veterinary medicine to reverse xylazine-induced sedation and ...
Giuseppe Floresta, Giuseppe Floresta, Vincenzo Patamia, Alberto Granzotto, Alberto Granzotto, Davide Arillotta, Davide Arillotta, Gabriele Duccio Papanti, Gabriele Duccio Papanti, Amira Guirguis, John M. Corkery, Giovanni Martinotti, Giovanni Martinotti, Stefano L. Sensi, Stefano L. Sensi, Stefano L. Sensi, Stefano L. Sensi, Fabrizio Schifano   +17 more
doaj   +1 more source

Editorial: Prescribing psychotropics: Misuse, abuse, dependence, withdrawal and addiction, Volume II

Frontiers in Psychiatry, 2022
Stefania Chiappini, Stefania Chiappini, Fabrizio Schifano, Giovanni Martinotti, Giovanni Martinotti   +4 more
doaj   +1 more source

A scoping review of thresholds for responder and time‐to‐event analysis of patient‐reported outcomes in breast cancer trials

British Journal of Clinical Pharmacology, EarlyView.
Patient‐reported outcomes (PROs) are essential for assessing clinical benefit and tolerability from the patient's perspective. In oncology trials, PRO data analysis often involves responder and time‐to‐event analyses, which depend on predefined thresholds to determine clinically meaningful change.
Anna Margarete Maria Thurner, Daniela Krepper, Micha Johannes Pilz, Lisa Marie Storz, Maike Thumfart, Johannes Maria Giesinger   +5 more
wiley   +1 more source

Editorial: Prescribing Psychotropics: Misuse, Abuse, Dependence, Withdrawal and Addiction

Frontiers in Psychiatry, 2021
Stefania Chiappini, Stefania Chiappini, Fabrizio Schifano, Giovanni Martinotti, Giovanni Martinotti   +4 more
doaj   +1 more source

From Veterinary Medicine to Illicit Drug Supply: Utilising Social Media to Explore the Rising Emergence of Veterinary Medicines in Human Health

Brain Sciences
Background/Objectives: The misuse of veterinary drugs is a growing concern, with increasing evidence of their presence in illicit drug markets and their use as alternatives to traditional substances. Methods: This study explores Reddit discussions on the
Josie Dunn, Fabrizio Schifano, Ed Dudley, Davide Arillotta, Amira Guirguis   +4 more
doaj   +1 more source