Results 11 to 20 of about 8,631,498 (387)

From Therapeutic Drug Monitoring to Model‐Informed Precision Dosing for Antibiotics

open access: yesClinical pharmacology and therapy, 2021
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have evolved as important tools to inform rational dosing of antibiotics in individual patients with infections.
S. Wicha   +6 more
semanticscholar   +1 more source

Personalized Therapy for Mycophenolate: Consensus Report by the International Association of Therapeutic Drug Monitoring and Clinical Toxicology.

open access: yesTherapeutic Drug Monitoring, 2021
When mycophenolic acid (MPA) was originally marketed for immunosuppressive therapy, fixed doses were recommended by the manufacturer. Awareness of the potential for a more personalized dosing has led to development of methods to estimate MPA area under ...
S. Bergan   +37 more
semanticscholar   +1 more source

Effect of Therapeutic Drug Monitoring vs Standard Therapy During Infliximab Induction on Disease Remission in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Randomized Clinical Trial.

open access: yesJournal of the American Medical Association (JAMA), 2021
Importance Proactive therapeutic drug monitoring (TDM), defined as individualized drug dosing based on scheduled monitoring of serum drug levels, has been proposed as an alternative to standard therapy to maximize efficacy and safety of infliximab and ...
S. W. Syversen   +32 more
semanticscholar   +1 more source

Therapeutic drug monitoring in drug overdose [PDF]

open access: yesBritish Journal of Clinical Pharmacology, 1999
The treatment of poisoned patients is still largely defined by history, clinical assessment and interpretation of ancillary investigations. Measurement of drug concentrations is clinically important for relatively few compounds. Most measurements form an adjunct to and should not be considered a substitute for clinical assessment.
Ian M Whyte, Andrew H. Dawson
openaire   +7 more sources

Determination of Osimertinib, Aumolertinib, and Furmonertinib in Human Plasma for Therapeutic Drug Monitoring by UPLC-MS/MS

open access: yesMolecules, 2022
The third-generation epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs), osimertinib, aumolertinib, and furmonertinib represent a new treatment option for patients with EGFR p.Thr790 Met (T790 M)-mutated non-small cell lung cancer ...
Ying Li   +6 more
doaj   +1 more source

Structure Analysis of the Interfering Substance N-methyl-2-phenylpropan-1-amine of Methamphetamine in Wastewater

open access: yesFayixue Zazhi, 2022
ObjectiveTo analyze the chemical structure of the interfering substance that affects the result of methamphetamine analysis in wastewater.MethodsA combination of GC-MS and liquid chromatography-quadrupole time-of-flight mass spectrometry (LC-QTOF-MS) was
ZHANG Ting-ting   +4 more
doaj   +1 more source

Antimicrobial therapeutic drug monitoring in critically ill adult patients: a Position Paper#

open access: yesIntensive Care Medicine, 2020
This Position Paper aims to review and discuss the available data on therapeutic drug monitoring (TDM) of antibacterials, antifungals and antivirals in critically ill adult patients in the intensive care unit (ICU).
M. Abdul-Aziz   +15 more
semanticscholar   +1 more source

Determination of five prostaglandin analogs in eyelash enhancing cosmetics by LC-MS/MS

open access: yesShanghai yufang yixue, 2022
ObjectiveTo determine bimatoprost, tafluprost ethyl amide, latanoprost, travoprost and tafluprost in eyelash enhancing cosmetics by establishing a LC-MS/MS method.MethodsThe samples were extracted with a 50% acetonitrile water solution. A salt mixture (
XU Yong   +4 more
doaj   +1 more source

Mass Fragmentation Characteristics of 4 Synthetic Cathinone Isomers [PDF]

open access: yesZhipu Xuebao, 2023
Synthetic cathinones, the designer analogs of the naturally occurring cathinone found in Khat, largely entered the recreational drug market at the end of the 2000s. They are a large class of new psychoactive substances (NPS) often used as substitutes for
JIA Wei;HU Shuang;LI Tao;LIU Cui-mei;WANG You-mei;HUA Zhen-dong
doaj   +1 more source

Monitoring drug adherence [PDF]

open access: yesTransplantation Reviews, 2015
Medication nonadherence is prevalent in transplant recipients and is a major reason for graft loss. The present review discusses the measurement of adherence in transplant recipients and strategies to improve adherence. SOURCES REVIEWED: Since adherence research is not confined to transplant recipients, our literature review included studies relevant ...
Sarah R. Lieber   +5 more
openaire   +3 more sources

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