Applying hierarchical task analysis to medication administration errors [PDF]
, 2006 Medication use in hospitals is a complex process and is dependent on the successful interaction of health professionals functioning within different disciplines.
Harrison, DJ, Lane, R, Stanton, NA
core +1 more source
Pharmaceutics, 2021 Parkinson’s disease (PD) is a progressive, neurodegenerative disorder primarily affecting dopaminergic neuronal systems, with impaired motor function as a consequence.
Urszula Adamiak-Giera +6 more
doaj +1 more source
A 3D Pancreatic Cancer Model with Integrated Optical Sensors for Noninvasive Metabolism Monitoring and Drug Screening [PDF]
Advanced Healthcare Materials 2024, 2401138A distinct feature of pancreatic ductal adenocarcinoma (PDAC) is a prominent tumor microenvironment (TME) with remarkable cellular and spatial heterogeneity that meaningfully impacts disease biology and treatment resistance. The dynamic crosstalk between cancer cells and the dense stromal compartment leads to spatially and temporally heterogeneous ...
arxiv +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
How the presentation of patient information and decision-support advisories influences opioid prescribing behavior: A simulation study [PDF]
, 2020 ObjectiveThe United States faces an opioid crisis. Integrating prescription drug monitoring programs into electronic health records offers promise to improve opioid prescribing practices.
Hussain, Mustafa I +4 more
core
Total and Unbound Pharmacokinetics of Cefiderocol in Critically Ill Patients
Pharmaceutics, 2022 Background: Cefiderocol is a siderophore cephalosporin antibiotic active against Gram-negative bacteria, including extended-spectrum beta-lactamase and carbapenemase-producing strains.
Noël Zahr +11 more
doaj +1 more source
Association Between Prescription Drug Monitoring Programs and Nonfatal and Fatal Drug Overdoses
Annals of Internal Medicine, 2018 The overuse of prescription opioids during the past 2 decades has evolved into a major public health issue in the United States. Opioid prescribing increased 350% between 1999 and 2015, from 180 to 640 morphine milligram equivalents per capita (1), with ...
David S. Fink +10 more
semanticscholar +1 more source
Brucella NyxA and NyxB dimerization enhances effector function during infection
FEBS Letters, EarlyView.Brucella abortus thrives inside cells thanks to the translocation of effector proteins that fine‐tune cellular functions. NyxA and NyxB are two effectors that destabilize the nucleolar localization of their host target, SENP3. We show that the Nyx proteins directly interact with each other and that their dimerization is essential for their function ...
Lison Cancade‐Veyre +4 more
wiley +1 more source
Everolimus dosing recommendations for tuberous sclerosis complex–associated refractory seizures [PDF]
, 2018 ObjectiveThe present analysis examined the exposure-response relationship by means of the predose everolimus concentration (C-min) and the seizure response in patients with tuberous sclerosis complex-associated seizures in the EXIST-3 study ...
Brandt, Christian +12 more
core +2 more sources
Determination of α-hydroxy acids in cosmetics by UHPLC-MS/MS
Shanghai yufang yixueObjectiveTo establish a UHPLC-MS/MS quantitative method for the determination of glucuronic acid， tartaric acid， glycolic acid， malic acid， lactic acid， citric acid， DL-2-hydroxybutyric acid sodium， mandelic acid， benzilic acid， hydroxycaprylic acid ...
RU Ge +5 more
doaj +1 more source