Results 151 to 160 of about 164,898 (351)

Effect of developmental changes on pharmacokinetics of drugs used in the treatment of infant acute lymphoblastic leukaemia—A comprehensive review

British Journal of Clinical Pharmacology, EarlyView.
While the event‐free survival (EFS) of children treated for acute lymphoblastic leukaemia (ALL) has improved greatly in the last decades, the EFS for patients diagnosed with ALL before the age of one is still under 50%. This outcome further decreases when infants have a rearrangement in the gene encoding histone‐lysine N‐methyltransferase 2A (KMT2A ...
Tirsa de Kluis, Leiah J. Brigitha, Lidwien M. Hanff, Alwin D. R. Huitema, Inge M. van der Sluis, Meta H. M. Diekstra   +5 more
wiley   +1 more source

Associations among drug acquisition and use behaviors, psychosocial attributes, and opioid-involved overdoses

BMC Public Health
Aims This study sought to develop and assess an exploratory model of how demographic and psychosocial attributes, and drug use or acquisition behaviors interact to affect opioid-involved overdoses.
James A. Swartz, Peipei Zhao, Ross Jacobucci, Dennis P. Watson, Mary Ellen Mackesy-Amiti, Dana Franceschini, A. David Jimenez   +6 more
doaj   +1 more source

Fentanyl and heroin contained in seized illicit drugs and overdose-related deaths in British Columbia, Canada: An observational analysis

, 2018
Nicholas Baldwin, Roger Gray, Anirudh Goel, Evan Wood, Jane A. Buxton, Launette Rieb   +5 more
openalex   +2 more sources

A plant-derived cocaine hydrolase prevents cocaine overdose lethality and attenuates cocaine-induced drug seeking behavior

, 2020
Katherine E. Larrimore, Latha Kannan, Robert Kendle, Tameem Jamal, Matthew Barcus, Kathryn Stefanko, Jacquelyn Kilbourne, Stephen Brimijoin, Chang‐Guo Zhan, Janet L. Neisewander, Tsafrir S. Mor   +10 more
openalex   +2 more sources

Short communication: Dynamic chemical labelling allows the measurement of the paracetamol toxicity biomarker microRNA‐122 in hospital clinical laboratories

British Journal of Clinical Pharmacology, EarlyView.
MicroRNA‐122 (miR‐122) is a sensitive biomarker for paracetamol‐induced liver injury. This study assessed the diagnostic performance of dynamic chemical labelling (DCL) combined with an immunoassay platform to quantify miR‐122 in human serum, as a proof‐of‐concept for hospital use.
Samar Alzeer, Antonio Marin‐Romero, Bárbara López‐Longarela, Juan J. Guardia‐Monteagudo, F. Javier Lopez‐Delgado, Salvatore Pernagallo, Juan J. Diaz‐Mochon, Mavys Tabraue‐Chavez, Kathleen Scullion, James W. Dear   +9 more
wiley   +1 more source

Intraspinal Drug Delivery Reservoir Refill Procedure by Non-Physician Clinicians: A Nation-Wide Survey of Training, Pocket Fill Experience, and Life-Long Learning Behaviors [PDF]

, 2016
Intraspinal drug delivery (IDD) is a safe and efficacious method used to deliver medications for the treatment of chronic neurologic disease that requires periodic reservoir refills that can place patients at risk for a rare, accidental but potentially ...
McGlothlen, Gail
core   +1 more source

Drug poisonings following bariatric surgery: Case series report

British Journal of Clinical Pharmacology, EarlyView.
Bariatric surgery alters gastrointestinal anatomy and physiology, which likely impacts upon oral medication absorption. Drug‐ and alcohol‐related deaths in this population are being increasingly reported; however, toxicological detail is lacking. Using data reported to the National Programme on Substance Use Mortality, we identified 18 deaths in people
Eman Mshari, Fannie LaJeunesse‐Trempe, Stephen Morley, Caroline Copeland   +3 more
wiley   +1 more source

Loneliness and fearfulness are associated with non-fatal drug overdose among people who inject drugs.

PLoS ONE
BackgroundPeople who inject drugs (PWID) experience high rates of drug overdose death with the risk of mortality increasing after each non-fatal event.
Oluwaseun Falade-Nwulia, Kathleen Ward, Karla D Wagner, Hamidreza Karimi-Sari, Jeffrey Hsu, Mark Sulkowski, Carl Latkin, Evaristus Nwulia   +7 more
doaj   +1 more source

Utility of serum lactate to predict drug-overdose fatality

, 2010
Alex F. Manini, Ashish Kumar, Dean Olsen, David Vlahov, Robert S. Hoffman   +4 more
openalex   +1 more source

Prescription opioid use and non-fatal overdose in a cohort of injection drug users

, 2015
Stephanie Lake, Evan Wood, Jane A. Buxton, Huiru Dong, Julio Montaner, Thomas Kerr   +5 more
openalex   +2 more sources