Results 41 to 50 of about 303,635 (348)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

ASSESSMENT OF PRESCRIPTION PATTERN AND PRESCRIPTION ERRORS USING THE WORLD HEALTH ORGANIZATION DRUG USE INDICATORS IN LADY READING HOSPITAL PESHAWAR, PAKISTAN: A RETROSPECTIVE STUDY

open access: yesKhyber Medical University Journal, 2018
OBJECTIVES: To assess and evaluate prescription pattern and prescription errors using World Health Organization (WHO) drug use indicators in the medical ward of Leady Reading Hospital, Peshawar, Pakistan.
Haya Hussain   +6 more
doaj  

A Budding Theory of Willful Patent Infringement: Orange Books, Colored Pills, and Greener Verdicts [PDF]

open access: yes, 2007
The rules of engagement in the brand-name versus generic-drug war are rapidly changing. Brand-name manufacturers face increasing competition from Canadian manufacturers of generic drugs, online drug companies, and Wal-Mart® Super Centers deciding to cash
Harkins, Christopher A.
core   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

open access: yesFEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies   +3 more
wiley   +1 more source

Potential intravenous drug interactions in intensive care

open access: yesRevista da Escola de Enfermagem da USP
OBJECTIVE To analyze potential intravenous drug interactions, and their level of severity associated with the administration of these drugs based on the prescriptions of an intensive care unit.
Maiara Benevides Moreira   +3 more
doaj   +1 more source

Drug prescriptions in Danish out-of-hours primary care: a 1-yearpopulation-based study

open access: yesScandinavian Journal of Primary Health Care, 2016
Objective: General practitioners are the first point of contact in Danish out-of-hours (OOH) primary care. The large number of contacts implies that prescribing behaviour may have considerable impact on health-care expenditures and quality of care.
Morten Bondo Christensen   +4 more
doaj   +1 more source

Opioid Analgesic Prescribing Practices of Dental Professionals in the United States [PDF]

open access: yes, 2017
The prescription of opioid analgesics by dental professionals is widespread in the United States. Policy makers, government agencies, and professional organizations consider this phenomenon a growing public health concern.
Okunseri, Christopher   +4 more
core   +2 more sources

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

open access: yesAging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel   +4 more
wiley   +1 more source

Interactive exploration of population scale pharmacoepidemiology datasets

open access: yes, 2020
Population-scale drug prescription data linked with adverse drug reaction (ADR) data supports the fitting of models large enough to detect drug use and ADR patterns that are not detectable using traditional methods on smaller datasets. However, detecting
Abadi M.   +4 more
core   +1 more source

Individual and county-level factors associated with use of multiple prescribers and multiple pharmacies to obtain opioid prescriptions in California. [PDF]

open access: yes, 2012
Use of multiple prescribers and pharmacies is a means by which some individuals misuse opioids. Community characteristics may be important determinants of the likelihood of this phenomenon independent of individual-level factors. This was a retrospective
Han, Huijun   +3 more
core   +2 more sources

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