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Computational drug repositioning with attention walking [PDF]

Scientific Reports
Drug repositioning aims to identify new therapeutic indications for approved medications. Recently, the importance of computational drug repositioning has been highlighted because it can reduce the costs, development time, and risks compared to ...
Jong-Hoon Park, Young-Rae Cho
doaj   +6 more sources

Drug repositioning based on individual bi-random walks on a heterogeneous network [PDF]

BMC Bioinformatics, 2019
Background Traditional drug research and development is high cost, time-consuming and risky. Computationally identifying new indications for existing drugs, referred as drug repositioning, greatly reduces the cost and attracts ever-increasing research ...
Yuehui Wang, Maozu Guo, Yazhou Ren, Lianyin Jia, Guoxian Yu   +4 more
doaj   +2 more sources

Drug Repositioning in Friedreich Ataxia [PDF]

Frontiers in Neuroscience, 2022
Friedreich ataxia is a rare neurodegenerative disorder caused by insufficient levels of the essential mitochondrial protein frataxin. It is a severely debilitating disease that significantly impacts the quality of life of affected patients and reduces ...
Alessandra Rufini, Alessandra Rufini, Alessandra Rufini, Florence Malisan, Ivano Condò, Roberto Testi, Roberto Testi   +6 more
doaj   +4 more sources

Drug repositioning in drug discovery of T2DM and repositioning potential of antidiabetic agents

Computational and Structural Biotechnology Journal, 2022
Repositioning or repurposing drugs account for a substantial part of entering approval pipeline drugs, which indicates that drug repositioning has huge market potential and value.
Sha Zhu, Qifeng Bai, Lanqing Li, Tingyang Xu   +3 more
doaj   +3 more sources

Some Aspects and Convergence of Human and Veterinary Drug Repositioning [PDF]

Molecules
Drug innovation traditionally follows a de novo approach with new molecules through a complex preclinical and clinical pathway. In addition to this strategy, drug repositioning has also become an important complementary approach, which can be shorter ...
Patrik Mag, Melinda Nemes-Terényi, Ákos Jerzsele, Péter Mátyus   +3 more
doaj   +2 more sources

Network mirroring for drug repositioning [PDF]

BMC Medical Informatics and Decision Making, 2017
Background Although drug discoveries can provide meaningful insights and significant enhancements in pharmaceutical field, the longevity and cost that it takes can be extensive where the success rate is low.
Sunghong Park, Dong-gi Lee, Hyunjung Shin   +2 more
doaj   +4 more sources

Large Language Model–Enhanced Drug Repositioning Knowledge Extraction via Long Chain-of-Thought: Development and Evaluation Study

JMIR Medical Informatics
BackgroundDrug repositioning is a pivotal strategy in pharmaceutical research, offering accelerated and cost-effective therapeutic discovery. However, biomedical information relevant to drug repositioning is often complex, dispersed, and underutilized ...
Hongyu Kang, Jiao Li, Li Hou, Xiaowei Xu, Si Zheng, Qin Li   +5 more
doaj   +2 more sources

Antiretroviral Drug Repositioning for Glioblastoma. [PDF]

Cancers (Basel)
Outcomes for glioblastoma (GBM) remain poor despite standard-of-care treatments including surgical resection, radiation, and chemotherapy. Intratumoral heterogeneity contributes to treatment resistance and poor prognosis, thus demanding novel therapeutic approaches.
Rivas SR, Mendez Valdez MJ, Chandar JS, Desgraves JF, Lu VM, Ampie L, Singh EB, Seetharam D, Ramsoomair CK, Hudson A, Ingle SM, Govindarajan V, Doucet-O'Hare TT, DeMarino C, Heiss JD, Nath A, Shah AH.   +16 more
europepmc   +3 more sources

Biology-Informed Matrix Factorization: An AI-Driven Framework for Enhanced Drug Repositioning. [PDF]

Biology (Basel)
Wang Y, Wang Y, Hu Y, Wang J.
europepmc   +2 more sources

A Study on Methodologies of Drug Repositioning Using Biomedical Big Data: A Focus on Diabetes Mellitus [PDF]

Endocrinology and Metabolism, 2022
Drug repositioning is a strategy for identifying new applications of an existing drug that has been previously proven to be safe. Based on several examples of drug repositioning, we aimed to determine the methodologies and relevant steps associated with ...
Suehyun Lee, Seongwoo Jeon, Hun-Sung Kim
doaj   +1 more source