Results 11 to 20 of about 59,924 (341)
Improving drug repositioning accuracy using non-negative matrix tri-factorization. [PDF]
Sci RepLi Q, Wang Y, Wang J, Zhao C.
europepmc +3 more sources
Current Issues in Molecular Biology, 2022 Pacliatxel is a taxol-based chemotherapeutic drug that is widely used to treat cancer. However, it can also induce peripheral neuropathy, which limits its use.
Ji Hwan Lee +3 more
doaj +1 more source
Effect and Mechanism of Herbal Medicines on Cisplatin-Induced Anorexia
Pharmaceuticals, 2022 Cisplatin is a well-known chemotherapeutic agent used to treat various types of cancers; however, it can also induce anorexia, which results in reduced food intake, loss of body weight, and lower quality of life.
Daeun Min +3 more
doaj +1 more source
Frontiers in Oncology, 2022 Daemonorops draco Blume (DD), also called dragon’s blood, has been used as a traditional Korean medicine, especially for relieving pain caused by wound infection. Recently, it has been described that DD has antibacterial and analgesic effects.
Moon Nyeo Park +11 more
doaj +1 more source
<i>In vitro</i> assessment of BBI608 in 2D and 3D culture models for drug repositioning in oral squamous cell carcinoma. [PDF]
Oncol RepPark DG +6 more
europepmc +3 more sources
Repositioned Drugs for Chagas Disease Unveiled via Structure-Based Drug Repositioning [PDF]
International Journal of Molecular Sciences, 2020 Chagas disease, caused by the parasite Trypanosoma cruzi, affects millions of people in South America. The current treatments are limited, have severe side effects, and are only partially effective. Drug repositioning, defined as finding new indications for already approved drugs, has the potential to provide new therapeutic options for Chagas. In this
Melissa F. Adasme +11 more
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Drug Repositioning Using Temporal Trajectories of Accompanying Comorbidities in Diabetes Mellitus [PDF]
Endocrinology and Metabolism, 2022 Background Most studies of systematic drug repositioning have used drug-oriented data such as chemical structures, gene expression patterns, and adverse effect profiles.
Namgi Park +4 more
doaj +1 more source
Integrated analysis for drug repositioning in migraine using genetic evidence and claims database. [PDF]
Front Big DataInokuchi S, Tajima T.
europepmc +3 more sources
International Journal of Epilepsy, 2016 AbstractRapid advances in pharmacotherapy and bioinformatics has led to the discovery and growing popularity of drug repositioning which includes re-investigating or recycling of existing drugs for new indications. There are innumerable advantages as well as challenges of drug repositioning. Since de-novo drug discovery takes plenty of time, effort and
Man Mohan Mehndiratta +4 more
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Drug repositioning: a brief overview [PDF]
Journal of Pharmacy and Pharmacology, 2020 Abstract Objectives Drug repositioning, that is, the use of a drug in an indication other than the one for which it was initially marketed, is a growing trend. Its origins lie mainly in the attrition experienced in recent years in the field of new drug discovery.
Jourdan, Jean-Pierre +3 more
openaire +4 more sources