Results 231 to 240 of about 26,660 (305)

Surgical management of recurrent oesophageal obstruction in a yearling Saddlebred filly

Equine Veterinary Education, EarlyView.
Summary This case report describes the diagnostic approach and surgical management of a yearling Saddlebred filly with recurrent oesophageal obstruction, likely caused by an acquired extraluminal oesophageal stricture. The filly initially presented with repeated episodes of oesophageal obstruction, which were resolved with sedation and nasogastric ...
K. M. Andrews, J. Melcher, J. F. Peroni, M. Perlini, E. M. Beasley   +4 more
wiley   +1 more source

Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment. [PDF]

PLoS One
Sanami S, Aghaamoo S, Ahmad S, Fazli A, Mansouri B, Nobre Oliveira JI, Rahmanian M.   +6 more
europepmc   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Drug repositioning pipeline integrating community analysis in drug-drug similarity networks and automated ATC community labeling to foster molecular docking analysis. [PDF]

Front Bioinform
Colibăşanu D, Groza V, Occhiuzzi MA, Grande F, Udrescu M, Udrescu L.   +5 more
europepmc   +1 more source

Use of Text Data in Identifying and Prioritizing Potential Drug Repositioning Candidates

, 2019
Majid Rastegar-Mojarad
openalex   +1 more source

Human IDO2 exhibits unique binding affinities distinct to those of human IDO1

The FEBS Journal, EarlyView.
Although indoleamine 2,3‐dioxygenase 2 (IDO2) is highly homologous to IDO1, it displays markedly lower catalytic activity. We found that IDO2 binds L‐tryptophan (L‐Trp) in a flipped orientation stabilized by the IDO2‐specific residue His143. Replacement of His143 with the IDO1‐equivalent tyrosine restored an IDO1‐like binding mode and increased ...
Shunsuke Nogi, Ayumu Takahashi, So Murakami, Nami Adachi, Tina Fujimoto, Yohta Fukuda, Taku Yamashita, Tsuyoshi Inoue, Hirofumi Tsujino   +8 more
wiley   +1 more source

Recent advances in drug repositioning and rediscovery for different therapeutic activities utilizing updated technological approaches. [PDF]

Mol Divers
Nossier ES, Anwar MM, El-Zahabi MA.
europepmc   +1 more source

A novel all‐in‐one dynamic wrinkle evaluation system: Development, validation and application in cosmetic industries

International Journal of Cosmetic Science, EarlyView.
Photo grading of dynamic lines in the dynamic line repeatability validation study. Abstract Objective This study aimed to develop and validate a novel, integrated dynamic wrinkle assessment system based on standardized, real‐time and multi‐angle facial images and video recordings, and to explore its potential application in evaluating the anti‐wrinkle ...
Xingzuo Liu, Juanjuan Chen, Chengda Ye, Andrew Steel, Yidong Tu, Frederic Flament, Jing Li   +6 more
wiley   +1 more source

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches. [PDF]

Proteomics
Perco P, Ley M, Kęska-Izworska K, Wojenska D, Bono E, Walter SM, Fillinger L, Kratochwill K.   +7 more
europepmc   +1 more source

Getting to the COR of Workarounds: A Resource Perspective on Deviating Usage of Critical Care Information Systems

Information Systems Journal, EarlyView.
ABSTRACT Workarounds in high‐hazard environments like intensive care units (ICUs) compromise safety and regulatory compliance. While prior research attributes these deviations to technology misfits and notes self‐reinforcing dynamics, the underlying mechanisms of aggravating workaround spirals remain understudied.
Pauline Kuss, Christian Meske, Martin Gersch, Stefan Schaller, Alica Thissen, Felix Balzer, Daniel Fürstenau   +6 more
wiley   +1 more source