Results 261 to 270 of about 59,924 (341)

Drug repositioning for oral cancer: Identifying candidate therapeutic agents

, 2015
Kellen Cristine Tjioe
openalex   +1 more source

DRUG REPOSITIONING: Revisiting the basic psychopharmacological mechanism of action for agomelatine and where it should be classified?

, 2019
OlumuyiwaJohn Fasipe, OluwatosinBeatrice Ibiyemi-Fasipe, PeterEhizokhale Akhideno, MuyiwaSamuel Fageyinbo   +3 more
openalex   +1 more source

Newly identified properties of known pharmaceuticals and myxobacterial small molecules revealed by screening for autophagy modulators

The FEBS Journal, EarlyView.
Autophagy is a cellular degradation process involved in, for example, immune responses to pathogens and neurodegeneration. To identify modulators of autophagy, we developed a microscopy‐based screening assay and identified previously unknown autophagy‐modulating activities in known drugs and natural products from myxobacteria and fungi.
Janine Fichtner, Yan Yan Beer, H. G. Mauricio Ramm, Sabrina Mühlen, Frank Surup, Jennifer Herrmann, Toni Luise Meister, Stephanie Pfaender, Ursula Bilitewski, Mark Brönstrup, Rolf Müller, Manfred Wirth, Eeva‐Liisa Eskelinen, Ingo Schmitz   +13 more
wiley   +1 more source

Using systems biology and drug repositioning approaches to discover FDA-approved drugs candidates for endometriosis treatment. [PDF]

PLoS One
Sanami S, Aghaamoo S, Ahmad S, Fazli A, Mansouri B, Nobre Oliveira JI, Rahmanian M.   +6 more
europepmc   +1 more source

Repositioning the Repurposed Drug, a Structural Study of Thalidomide Analogs

, 2019
Mahshid Rahmat, Romanos Sklavenitis Pistofidis, Irene M. Ghobrial   +2 more
openalex   +1 more source

Histopathology, Diagnosis, Management and Treatment Outcomes of Cemental Tears: A Retrospective Observational Cohort Study

International Endodontic Journal, EarlyView.
ABSTRACT Introduction Diagnosing cemental tears remains challenging, and treatment outcomes can be unpredictable; recommendations for their diagnosis and management are primarily based on case reports and anecdotal experience. Although a classification has been developed for cemental tears, its clinical applicability and importance have yet to be ...
Angeline Hui Cheng Lee, Mei Zhi Ting, May Chun Mei Wong, Chengfei Zhang   +3 more
wiley   +1 more source

Computational Drug Repositioning in Cardiorenal Disease: Opportunities, Challenges, and Approaches. [PDF]

Proteomics
Perco P, Ley M, Kęska-Izworska K, Wojenska D, Bono E, Walter SM, Fillinger L, Kratochwill K.   +7 more
europepmc   +1 more source

Getting to the COR of Workarounds: A Resource Perspective on Deviating Usage of Critical Care Information Systems

Information Systems Journal, EarlyView.
ABSTRACT Workarounds in high‐hazard environments like intensive care units (ICUs) compromise safety and regulatory compliance. While prior research attributes these deviations to technology misfits and notes self‐reinforcing dynamics, the underlying mechanisms of aggravating workaround spirals remain understudied.
Pauline Kuss, Christian Meske, Martin Gersch, Stefan Schaller, Alica Thissen, Felix Balzer, Daniel Fürstenau   +6 more
wiley   +1 more source

Translational Informatics Driven Drug Repositioning for Neurodegenerative Disease. [PDF]

Curr Neuropharmacol
Zheng X, Chen J, Zhang Y, Hu S, Bi C, Singla RK, Kamal MA, Horimoto K, Shen B.   +8 more
europepmc   +1 more source

Evaluating the Safety, Feasibility and Acceptability of Weighted Blankets in Acute Care for People With Dementia: A Randomised Control Trial

Journal of Advanced Nursing, EarlyView.
ABSTRACT Aim To evaluate the safety, feasibility and acceptability of weighted blankets for patients with dementia who experience agitation in acute care. Design Randomised controlled trial. Methods Patients with dementia experiencing agitation at a single hospital were recruited between May 2023 and January 2024. Participants were randomly assigned to
A. Fox, E. Tomkins, M. Valcovich, E. Ballard   +3 more
wiley   +1 more source