Results 31 to 40 of about 59,924 (341)
Viruses, 2020 Traditionally, drug discovery utilises a de novo design approach, which requires high cost and many years of drug development before it reaches the market.
Zheng Yao Low +2 more
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An in silico drug repositioning workflow for host-based antivirals
STAR Protocols, 2021 Summary: Drug repositioning represents a cost- and time-efficient strategy for drug development. Artificial intelligence-based algorithms have been applied in drug repositioning by predicting drug-target interactions in an efficient and high throughput ...
Zexu Li +4 more
doaj +1 more source
Drug repositioning for personalized medicine [PDF]
Genome Medicine, 2012 Human diseases can be caused by complex mechanisms involving aberrations in numerous proteins and pathways. With recent advances in genomics, elucidating the molecular basis of disease on a personalized level has become an attainable goal. In many cases, relevant molecular targets will be identified for which approved drugs already exist, and the ...
Li, Yvonne Y, Jones, Steven JM
openaire +2 more sources
Repositioning Natural Products in Drug Discovery [PDF]
Molecules, 2020 Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [...]
Rastelli, G. +3 more
openaire +4 more sources
A Systematic Approach to Identifying Protein-Ligand Binding Profiles on a Proteome Scale [PDF]
, 2008 Identification of protein-ligand interaction networks on a proteome scale is crucial to address a wide range of biological problems such as correlating molecular functions to physiological processes and designing safe and efficient therapeutics.
Lei Xie +3 more
core +2 more sources
BMC Bioinformatics, 2018 Background Drug repositioning is the process of identifying new uses for existing drugs. Computational drug repositioning methods can reduce the time, costs and risks of drug development by automating the analysis of the relationships in pharmacology ...
Pathima Nusrath Hameed +3 more
doaj +1 more source
RepCOOL: computational drug repositioning via integrating heterogeneous biological networks
Journal of Translational Medicine, 2020 Background It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in drug development.
Ghazale Fahimian +3 more
doaj +1 more source
BMC Bioinformatics, 2021 Background Drug repositioning refers to the identification of new indications for existing drugs. Drug-based inference methods for drug repositioning apply some unique features of drugs for new indication prediction. Complementary information is provided
Hailin Chen, Zuping Zhang, Jingpu Zhang
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Recent computational drug repositioning strategies against SARS-CoV-2
Computational and Structural Biotechnology Journal, 2022 Since COVID-19 emerged in 2019, significant levels of suffering and disruption have been caused on a global scale. Although vaccines have become widely used, the virus has shown its potential for evading immunities or acquiring other novel ...
Lu Lu +6 more
doaj +1 more source
Repositioning of Verrucosidin, a purported inhibitor of chaperone protein GRP78, as an inhibitor of mitochondrial electron transport chain complex I. [PDF]
, 2013 Verrucosidin (VCD) belongs to a group of fungal metabolites that were identified in screening programs to detect molecules that preferentially kill cancer cells under glucose-deprived conditions.
Chen, Thomas C +8 more
core +2 more sources