Results 31 to 40 of about 26,660 (305)
An in silico drug repositioning workflow for host-based antivirals
STAR Protocols, 2021 Summary: Drug repositioning represents a cost- and time-efficient strategy for drug development. Artificial intelligence-based algorithms have been applied in drug repositioning by predicting drug-target interactions in an efficient and high throughput ...
Zexu Li +4 more
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Recent computational drug repositioning strategies against SARS-CoV-2
Computational and Structural Biotechnology Journal, 2022 Since COVID-19 emerged in 2019, significant levels of suffering and disruption have been caused on a global scale. Although vaccines have become widely used, the virus has shown its potential for evading immunities or acquiring other novel ...
Lu Lu +6 more
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Drug repositioning for personalized medicine [PDF]
Genome Medicine, 2012 Human diseases can be caused by complex mechanisms involving aberrations in numerous proteins and pathways. With recent advances in genomics, elucidating the molecular basis of disease on a personalized level has become an attainable goal. In many cases, relevant molecular targets will be identified for which approved drugs already exist, and the ...
Li, Yvonne Y, Jones, Steven JM
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Repositioning Natural Products in Drug Discovery [PDF]
Molecules, 2020 Drug repositioning (o repurposing) has become one of the most popular and successful strategies to reduce failures typically associated with drug discovery [...]
Rastelli, G. +3 more
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BMC Bioinformatics, 2018 Background Drug repositioning is the process of identifying new uses for existing drugs. Computational drug repositioning methods can reduce the time, costs and risks of drug development by automating the analysis of the relationships in pharmacology ...
Pathima Nusrath Hameed +3 more
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RepCOOL: computational drug repositioning via integrating heterogeneous biological networks
Journal of Translational Medicine, 2020 Background It often takes more than 10 years and costs more than 1 billion dollars to develop a new drug for a particular disease and bring it to the market. Drug repositioning can significantly reduce costs and time in drug development.
Ghazale Fahimian +3 more
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Drug repositioning for orphan diseases [PDF]
Briefings in Bioinformatics, 2011 The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as
Divya, Sardana +5 more
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Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells
Frontiers in Pharmacology, 2023 Introduction: Among skin cancers, melanoma has a high mortality rate. Recent advances in immunotherapy, particularly through immune checkpoint modulation, have improved the clinical treatment of melanoma.
Na-Ra Han +5 more
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Computational Drug Repositioning: Current Progress and Challenges
Applied Sciences, 2020 Novel drug discovery is time-consuming, costly, and a high-investment process due to the high attrition rate. Therefore, many trials are conducted to reuse existing drugs to treat pressing conditions and diseases, since their safety profiles and ...
Younhee Ko
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Computational and Structural Biotechnology Journal, 2021 Identification of exact causative genes is important for in silico drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of ...
Huan Gao +11 more
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