Results 41 to 50 of about 26,660 (305)
Enriching limited information on rare diseases from heterogeneous networks for drug repositioning
BMC Medical Informatics and Decision Making, 2021 Background The historical data of rare disease is very scarce in reality, so how to perform drug repositioning for the rare disease is a great challenge.
Hongkui Cao +5 more
doaj +1 more source
Drug Repositioning for Hand, Foot, and Mouth Disease
Viruses, 2022 Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice.
Ran Yan +8 more
doaj +1 more source
Drug combination therapy increases successful drug repositioning [PDF]
Drug Discovery Today, 2016 Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years.
Wei, Sun +2 more
openaire +2 more sources
DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. [PDF]
PLoS ONE, 2017 Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and ...
Hongyu Wu +3 more
doaj +1 more source
MeSHDD: Literature-based drug-drug similarity for drug repositioning [PDF]
Journal of the American Medical Informatics Association, 2016 Objective: Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms.
Brown, Adam, Patel, Chirag
openaire +3 more sources
Turning genome-wide association study findings into opportunities for drug repositioning
Computational and Structural Biotechnology Journal, 2020 Drug development is a very costly and lengthy process, while repositioned or repurposed drugs could be brought into clinical practice within a shorter time-frame and at a much reduced cost.
Alexandria Lau, Hon-Cheong So
doaj +1 more source
Biomedicines, 2023 Drug repositioning offers the significant advantage of greatly reducing the cost and time of drug discovery by identifying new therapeutic indications for existing drugs.
Yoonbee Kim, Young-Rae Cho
doaj +1 more source
Conductive Bonding and System Architectures for High‐Performance Flexible Electronics
Advanced Functional Materials, EarlyView.This review outlines bonding technologies and structural design strategies that support high‐performance flexible and stretchable electronics. Bonding approaches such as surface‐activated bonding and anisotropic conductive films, together with system‐level architectures including buffer layers and island‐bridge structures, possess distinct mechanical ...
Kazuma Nakajima, Kenjiro Fukuda
wiley +1 more source
DrugMechDB: A Curated Database of Drug Mechanisms
Scientific Data, 2023 Computational drug repositioning methods have emerged as an attractive and effective solution to find new candidates for existing therapies, reducing the time and cost of drug development.
Adriana Carolina Gonzalez-Cavazos +8 more
doaj +1 more source
Drug repositioning based on heterogeneous networks and variational graph autoencoders
Frontiers in Pharmacology, 2022 Predicting new therapeutic effects (drug repositioning) of existing drugs plays an important role in drug development. However, traditional wet experimental prediction methods are usually time-consuming and costly.
Song Lei, Xiujuan Lei, Lian Liu
doaj +1 more source