Results 41 to 50 of about 59,924 (341)

Drug repositioning for orphan diseases [PDF]

Briefings in Bioinformatics, 2011
The need and opportunity to discover therapeutics for rare or orphan diseases are enormous. Due to limited prevalence and/or commercial potential, of the approximately 6000 orphan diseases (defined by the FDA Orphan Drug Act as
Divya, Sardana, Cheng, Zhu, Minlu, Zhang, Ranga C, Gudivada, Lun, Yang, Anil G, Jegga   +5 more
openaire   +2 more sources

DMAP: a connectivity map database to enable identification of novel drug repositioning candidates [PDF]

, 2015
BACKGROUND: Drug repositioning is a cost-efficient and time-saving process to drug development compared to traditional techniques. A systematic method to drug repositioning is to identify candidate drug's gene expression profiles on target disease ...
Chen, Jake Y., Huang, Hui, Ibrahim, Sara, Nguyen, Thanh, Shantharam, Sandeep, Yue, Zongliang   +5 more
core   +2 more sources

Computational Drug Repositioning: Current Progress and Challenges

Applied Sciences, 2020
Novel drug discovery is time-consuming, costly, and a high-investment process due to the high attrition rate. Therefore, many trials are conducted to reuse existing drugs to treat pressing conditions and diseases, since their safety profiles and ...
Younhee Ko
doaj   +1 more source

Maltol has anti-cancer effects via modulating PD-L1 signaling pathway in B16F10 cells

Frontiers in Pharmacology, 2023
Introduction: Among skin cancers, melanoma has a high mortality rate. Recent advances in immunotherapy, particularly through immune checkpoint modulation, have improved the clinical treatment of melanoma.
Na-Ra Han, Na-Ra Han, Hi-Joon Park, Seong-Gyu Ko, Seong-Gyu Ko, Phil-Dong Moon   +5 more
doaj   +1 more source

Repurposing drugs to target nonalcoholic steatohepatitis [PDF]

, 2019
Nonalcoholic fatty liver disease (NAFLD) is a complex disorder that has evolved in recent years as the leading global cause of chronic liver damage.
Pirola, Carlos José, Sookoian, Silvia Cristina   +1 more
core   +1 more source

Differential spatial repositioning of activated genes in Biomphalaria glabrata snails infected with Schistosoma mansoni [PDF]

, 2014
Copyright @ 2014 Arican-Goktas et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and
A Zarjou, AE Lockyer, AE Lockyer, AE Lockyer, AN Miller, C Li, C Perrin, CM Adema, CS Richards, D Zink, E Odoemelam, EC Odoemelam, EV Volpi, H Bierne, HA Foster, HA Foster, Halime D. Arican-Goktas, I Szczerbal, IS Mehta, JA Croft, JM Bridger, Joanna M. Bridger, KJ Livak, KJ Meaburn, KJ Meaburn, KK1 Geyer, L Chitsulo, LA Hertel, M Cremer, M Knight, M Knight, Malcolm K. Jones, Matty Knight, MG Castillo, N Raghavan, N Raghavan, P Fraser, PF Basch, S Fneich, S Jin, SD Bernal, TP Yoshino, UK Hahn, UK Hahn, W Ittiprasert, W Ittiprasert, W Ittiprasert, Wannaporn Ittiprasert, Y Hu   +48 more
core   +7 more sources

Drug repositioning based on network-specific core genes identifies potential drugs for the treatment of autism spectrum disorder in children

Computational and Structural Biotechnology Journal, 2021
Identification of exact causative genes is important for in silico drug repositioning based on drug-gene-disease relationships. However, the complex polygenic etiology of the autism spectrum disorder (ASD) is a challenge in the identification of ...
Huan Gao, Yuan Ni, Xueying Mo, Dantong Li, Shan Teng, Qingsheng Huang, Shuai Huang, Guangjian Liu, Sheng Zhang, Yaping Tang, Long Lu, Huiying Liang   +11 more
doaj   +1 more source

Disruption of the developmental programme of Trypanosoma brucei by genetic ablation of TbZFP1, a differentiation-enriched CCCH protein [PDF]

, 2005
The regulation of differentiation is particularly important in microbial eukaryotes that inhabit multiple environments. The parasite Trypanosoma brucei is an extreme example of this, requiring exquisite gene regulation during transmission from mammals to
Hendriks, Edward F, Matthews, Keith R
core   +1 more source

Enriching limited information on rare diseases from heterogeneous networks for drug repositioning

BMC Medical Informatics and Decision Making, 2021
Background The historical data of rare disease is very scarce in reality, so how to perform drug repositioning for the rare disease is a great challenge.
Hongkui Cao, Liang Zhang, Bo Jin, Shicheng Cheng, Xiaopeng Wei, Chao Che   +5 more
doaj   +1 more source

DHLP 1&2: Giraph based distributed label propagation algorithms on heterogeneous drug-related networks

, 2020
Background and Objective: Heterogeneous complex networks are large graphs consisting of different types of nodes and edges. The knowledge extraction from these networks is complicated. Moreover, the scale of these networks is steadily increasing.
Ghadiri, Nasser, Maleki, Erfan Farhangi, Maleki, Zeinab, Shahreza, Maryam Lotfi   +3 more
core   +1 more source