Results 51 to 60 of about 26,660 (305)
Advanced Healthcare Materials, EarlyView.The repair and regeneration of brain tissue faces both biological and technical challenges. Injectable bioscaffolds offer new opportunities to stimulate tissue regrowth in the brain by recruiting neural stem cells. Here, the translational issues are reviewed that need to be address to advance this promising new therapeutic approach from the bench to ...
Michel Modo, Alena Kisel
wiley +1 more source
Drug Repositioning for Gynecologic Tumors: A New Therapeutic Strategy for Cancer
The Scientific World Journal, 2015 The goals of drug repositioning are to find a new pharmacological effect of a drug for which human safety and pharmacokinetics are established and to expand the therapeutic range of the drug to another disease. Such drug discovery can be performed at low
Kouji Banno +7 more
doaj +1 more source
A Review of Current In Silico Methods for Repositioning Drugs and Chemical Compounds
Frontiers in Oncology, 2021 Drug repositioning is a new way of applying the existing therapeutics to new disease indications. Due to the exorbitant cost and high failure rate in developing new drugs, the continued use of existing drugs for treatment, especially anti-tumor drugs ...
Binsheng He +5 more
doaj +1 more source
Multivalent Protein Nanorings for Broad and Potent SARS‐CoV‐2 Neutralization
Advanced Healthcare Materials, EarlyView.A protein‐only, modular multivalent nanoscaffold displaying 20 anchor points, decorated with two different binders (10 of each), targeting the SARS‐CoV‐2 receptor‐binding domain is presented. The construct self‐assembles into stable, biocompatible, homogeneous nanoparticles, exhibit synergistic binding with fM IC50 values. It also detects spike at 9 ng
Molood Behbahanipour +11 more
wiley +1 more source
In Vitro Screening for Drug Repositioning [PDF]
SLAS Discovery, 2015 Drug repositioning or repurposing has received much coverage in the scientific literature in recent years and has been responsible for the generation of both new intellectual property and investigational new drug submissions. The literature indicates a significant trend toward the use of computational- or informatics-based methods for generating ...
Graeme F, Wilkinson, Kevin, Pritchard
openaire +2 more sources
Topological network measures for drug repositioning [PDF]
Briefings in Bioinformatics, 2020 Abstract Drug repositioning has received increased attention since the past decade as several blockbuster drugs have come out of repositioning. Computational approaches are significantly contributing to these efforts, of which, network-based methods play a key role.
Badkas, Apurva +2 more
openaire +3 more sources
Advanced Healthcare Materials, EarlyView.Myocardial infarction often leads to pathological remodelling and ventricular dilatation, key features of HFrEF. This study introduces a personalized, 3D‐printed cardiac restraint device (CARD) printed using rationally designed inks displaying the requested printability and mechanical properties.
Nicola Mansour +6 more
wiley +1 more source
Advanced Healthcare Materials, EarlyView.Percutaneous prosthetic venous valves are fabricated by embedding stents in an electrospun matrix that extends luminally to form leaflets. The design shields leaflets from hyperplastic cells, isolates struts from blood contact, and avoids discrete anchoring points.
Dario Arcuti +6 more
wiley +1 more source
Predicting Drug-Disease Association Based on Ensemble Strategy
Frontiers in Genetics, 2021 Drug repositioning is used to find new uses for existing drugs, effectively shortening the drug research and development cycle and reducing costs and risks. A new model of drug repositioning based on ensemble learning is proposed.
Jianlin Wang +4 more
doaj +1 more source
Metformin and chloroquine enhanced the efficacy of cytarabine in acute lymphoblastic leukemia cell lines: a drug repositioning approach. [PDF]
Sci RepPoodeh AM +7 more
europepmc +3 more sources