DrugSig: A resource for computational drug repositioning utilizing gene expression signatures. [PDF]
PLoS ONE, 2017 Computational drug repositioning has been proved as an effective approach to develop new drug uses. However, currently existing strategies strongly rely on drug response gene signatures which scattered in separated or individual experimental data, and ...
Hongyu Wu +3 more
doaj +1 more source
Drug Repositioning for Hand, Foot, and Mouth Disease
Viruses, 2022 Hand, foot, and mouth disease (HFMD) is a highly contagious disease in children caused by a group of enteroviruses. HFMD currently presents a major threat to infants and young children because of a lack of antiviral drugs in clinical practice.
Ran Yan +8 more
doaj +1 more source
RESKO: Repositioning drugs by using side effects and knowledge from ontologies [PDF]
, 2018 The objective of drug repositioning is to apply existing drugs to different diseases or medical conditions than the original target, and thus alleviate to a certain extent the time and cost expended in drug development.
Graham, Yitka +3 more
core +1 more source
Drug combination therapy increases successful drug repositioning [PDF]
Drug Discovery Today, 2016 Repositioning of approved drugs has recently gained new momentum for rapid identification and development of new therapeutics for diseases that lack effective drug treatment. Reported repurposing screens have increased dramatically in number in the past five years.
Wei, Sun +2 more
openaire +2 more sources
Synergistic drug combinations from electronic health records and gene expression. [PDF]
, 2016 ObjectiveUsing electronic health records (EHRs) and biomolecular data, we sought to discover drug pairs with synergistic repurposing potential. EHRs provide real-world treatment and outcome patterns, while complementary biomolecular data, including ...
Chen, William +19 more
core +2 more sources
Schistosomes and snails: A molecular encounter [PDF]
, 2014 Copyright © 2014 Knight, Arican-Goktas, Ittiprasert, Odoemelam, Miller and Bridger. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Arican-Goktas, HD +5 more
core +3 more sources
MeSHDD: Literature-based drug-drug similarity for drug repositioning [PDF]
Journal of the American Medical Informatics Association, 2016 Objective: Drug repositioning is a promising methodology for reducing the cost and duration of the drug discovery pipeline. We sought to develop a computational repositioning method leveraging annotations in the literature, such as Medical Subject Heading (MeSH) terms.
Brown, Adam, Patel, Chirag
openaire +3 more sources
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad +5 more
core +1 more source
Representation learning of drug and disease terms for drug repositioning
, 2017 Drug repositioning (DR) refers to identification of novel indications for the approved drugs. The requirement of huge investment of time as well as money and risk of failure in clinical trials have led to surge in interest in drug repositioning.
Anand, Ashish, Manchanda, Sahil
core +1 more source
Novel therapeutics for coronary artery disease from genome-wide association study data [PDF]
, 2015 BACKGROUND: Coronary artery disease (CAD), one of the leading causes of death globally, is influenced by both environmental and genetic risk factors. Gene-centric genome-wide association studies (GWAS) involving cases and controls have been remarkably ...
Ballouz, S. +7 more
core +1 more source