Results 1 to 10 of about 3,896,424 (394)

Antifungal Drug Repurposing [PDF]

Antibiotics, 2020
Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including ...
Jong H. Kim, Luisa W. Cheng, Kathleen L. Chan, Christina C. Tam, Noreen Mahoney, Mendel Friedman, Mikhail Martchenko Shilman, Kirkwood M. Land   +7 more
doaj   +3 more sources

Phenotype versus genotype to optimize cancer dosing in the clinical setting—focus on 5‐fluorouracil and tyrosine kinase inhibitors

Pharmacology Research & Perspectives
Cancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival.
Jennifer H. Martin, Peter Galettis, Alex Flynn, Jennifer Schneider   +3 more
doaj   +1 more source

Molecular-evaluated and explainable drug repurposing for COVID-19 using ensemble knowledge graph embedding

Scientific Reports, 2023
The search for an effective drug is still urgent for COVID-19 as no drug with proven clinical efficacy is available. Finding the new purpose of an approved or investigational drug, known as drug repurposing, has become increasingly popular in recent ...
M. Islam, Diego Amaya-Ramirez, B. Maigret, M. Devignes, Sabeur Aridhi, Malika Smaïl-Tabbone   +5 more
semanticscholar   +1 more source

Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]

, 2019
Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E., Chan, Jinyan, Gu, Jinghua, Turner, Jacob A., Wang, Xuan   +4 more
core   +1 more source

On the integration of in silico drug design methods for drug repurposing [PDF]

, 2017
Drug repurposing has become an important branch of drug discovery. Several computational approaches that help to uncover new repurposing opportunities and aid the discovery process have been put forward, or adapted from previous applications. A number of
Chen, Hongming, Engkvist, Ola, MARCH VILA, ERIC, PINZI, LUCA, RASTELLI, Giulio, Sturm, Noã, TINIVELLA, ANNACHIARA   +6 more
core   +2 more sources

DeCoST: A New Approach in Drug Repurposing From Control System Theory

Frontiers in Pharmacology, 2018
In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose.
Thanh M. Nguyen, Syed A. Muhammad, Sara Ibrahim, Lin Ma, Jinlei Guo, Baogang Bai, Bixin Zeng   +6 more
doaj   +1 more source

Leveraging generative AI to prioritize drug repurposing candidates for Alzheimer’s disease with real-world clinical validation

npj Digital Medicine
Drug repurposing represents an attractive alternative to the costly and time-consuming process of new drug development, particularly for serious, widespread conditions with limited effective treatments, such as Alzheimer’s disease (AD).
Chao Yan, M. Grabowska, Alyson L. Dickson, Bingshan Li, Zhexing Wen, Dan M. Roden, C. Michael Stein, Peter J. Embí, Josh F. Peterson, Q. Feng, Brad Malin, Wei-Qi Wei   +11 more
semanticscholar   +1 more source

Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Phanstiel, Otto, Reigada, Chantal, Valera Vera, Edward Augusto   +5 more
core   +1 more source

Artificial intelligence in COVID-19 drug repurposing

The Lancet: Digital Health, 2020
Summary: Drug repurposing or repositioning is a technique whereby existing drugs are used to treat emerging and challenging diseases, including COVID-19.
Yadi Zhou, PhD, Fei Wang, ProfPhD, Jian Tang, ProfPhD, Ruth Nussinov, ProfPhD, Feixiong Cheng, ProfPhD   +4 more
doaj   +1 more source

TBK1, a prioritized drug repurposing target for amyotrophic lateral sclerosis: evidence from druggable genome Mendelian randomization and pharmacological verification in vitro

BMC Medicine
Background There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment.
Qingqing Duan, Hang Wang, Wei-Ming Su, Xiaohong Gu, Xiao-Fei Shen, Zheng Jiang, Yan-Ling Ren, Bei Cao, Guo-Bo Li, Yi Wang, Yongping Chen   +10 more
semanticscholar   +1 more source