Advanced Science, EarlyView.Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu +7 more
wiley +1 more source
Transcriptomics- and Genomics-Guided Drug Repurposing for the Treatment of Vesicular Hand Eczema
PharmaceuticsVesicular hand eczema (VHE), a clinical subtype of hand eczema (HE), showed limited responsiveness to alitretinoin, the only approved systemic treatment for severe chronic HE. This emphasizes the need for alternative treatment approaches.
Fieke M. Rosenberg +7 more
doaj +1 more source
Systems biology strategy for drug potentiating through drug repurposing:bisphosphonates beyond osteoporosis treatment [PDF]
, 2018 Goltsov, Alexey +2 more
core +2 more sources
Sensing and Reprogramming Surface Receptor Activation With Synthetic Transcriptional Circuits
Advanced Science, EarlyView.A synthetic receptor‐signalling induced transcription (RESIT) circuit is designed based on receptor activation mediated split protease complementation and release of membrane‐tethered synthetic transcriptional modules. The RESIT system enables probing Ca2+ entry, receptor tyrosine kinase (RTK) activities and Ras activation, and reprogramming RTK ...
Fei Liu +5 more
wiley +1 more source
How drug repurposing can advance drug discovery: challenges and opportunities
Frontiers in Drug DiscoveryTraditional de novo drug discovery, which typically presents an 11% approval rate from phase I trials and even higher failure rates in fields like neurodegeneration, often requires two to three billion dollars and 10–17 years per new drug.
Luca Pinzi +2 more
doaj +1 more source
From Business model to Business model portfolio in the european biopharmaceutical industry [PDF]
At the crossroad of firm's core competencies and of the anticipations of consumers' needs, the business model approach complements corporate and business strategy approaches.
Tristan Rouselle +2 more
core
Advanced Science, EarlyView.We report a rational design strategy for STING antagonists by dual covalent targeting of Cys292/309 in its C‐terminal domain, directly preventing functional oligomerization. Through covalent warhead repurposing, we identified P005091 and revealed its unique dual‐cysteine mechanism.
Yuxuan Zhao +23 more
wiley +1 more source
The Evaluation of Mefloquine Drug Repurposing on Acute Myeloid Leukemia [PDF]
, 2018 The aim of this study is to observe cell proliferation, cell viability, apoptosis, and autophagy on acute myeloid leukemia (AML) cell lines, NB4 and U937, with the drug repurposing of mefloquine (MQ).
Corey, Seth +3 more
core +1 more source
Multimodal Wearable Biosensing Meets Multidomain AI: A Pathway to Decentralized Healthcare
Advanced Science, EarlyView.Multimodal biosensing meets multidomain AI. Wearable biosensors capture complementary biochemical and physiological signals, while cross‐device, population‐aware learning aligns noisy, heterogeneous streams. This Review distills key sensing modalities, fusion and calibration strategies, and privacy‐preserving deployment pathways that transform ...
Chenshu Liu +10 more
wiley +1 more source
IUPHAR review – Data-driven computational drug repurposing approaches for opioid use disorder
Pharmacological ResearchOpioid Use Disorder (OUD) is a chronic and relapsing condition characterized by the misuse of opioid drugs, causing significant morbidity and mortality in the United States.
Zhenxiang Gao, Pingjian Ding, Rong Xu
doaj +1 more source