Results 171 to 180 of about 3,896,424 (394)

Risk assessment of drug-induced Long QT Syndrome for some COVID-19 repurposed drugs [PDF]

, 2020
Véronique Michaud, Pamela Dow, Sweilem B. Al Rihani, Malavika Deodhar, Meghan J. Arwood, Brian Cicali, Jacques Turgeon   +6 more
openalex   +1 more source

Drug repurposing in cardiology [PDF]

Netherlands Heart Journal, 2020
van Driel, B. O., van der Velden, J.
openaire   +4 more sources

Cytokine‐Engineered Chimeric Antigen Receptor‐T Cell Therapy: How to Balance the Efficacy and Toxicity

Advanced Science, EarlyView.
Cytokine‐engineered CAR‐T cells represent a promising immunotherapy against malignancies due to direct tumor killing and potent immunity response. However, significant toxicities, including CRS and ICANS, have restricted clinical applications. How to keep the risk‐benefit balance of the advanced therapy is of great importance for maximizing the benefit
Xinru Zhang, Gulizeba Aimaiti, Yuanye Guan, Yuzhe Sha, Wei Zhou, Jiefeng Shen, Bo Zhao, Wei‐En Yuan   +7 more
wiley   +1 more source

MELEGROS: Monolithic Elephant‐Inspired Gripper with Optical Sensors

Advanced Science, EarlyView.
MELEGROS is a monolithic, elephant‐inspired soft gripper integrating 3D‐printed optical sensors within a pneumatically actuated lattice. Simulation‐guided design decouples tactile and proprioceptive sensing. Characterized through grasping tests, MELEGROS can reach, scoop, and grasp, showcasing a paradigm where fully embedded sensing and continuous ...
Petr Trunin, Diana Cafiso, Anderson Brazil Nardin, Trevor Exley, Lucia Beccai   +4 more
wiley   +1 more source

Fusobacterium nucleatum: An Overview of Evidence, Demi-Decadal Trends, and Its Role in Adverse Pregnancy Outcomes and Various Gynecological Diseases, including Cancers

Cells
Gynecological and obstetric infectious diseases are crucial to women’s health. There is growing evidence that links the presence of Fusobacterium nucleatum (F. nucleatum), an anaerobic oral commensal and potential periodontal pathogen, to the development
Arunita Ghosh, Ken Jaaback, Angela Boulton, Michelle Wong-Brown, Steve Raymond, Partha Dutta, Nikola A. Bowden, Arnab Ghosh   +7 more
doaj   +1 more source

High-Throughput Flow Cytometry Identifies Small-Molecule Inhibitors for Drug Repurposing in T-ALL [PDF]

, 2018
Dominique Perez, Christian K. Nickl, Anna Waller, Cristina Delgado-Martín, Travis A. Woods, Nitesh Sharma, Michelle L. Hermiston, Mignon L. Loh, Stephen P. Hunger, Stuart S. Winter, Alexandre Chigaev, Bruce S. Edwards, Larry A. Sklar, Ksenia Matlawska‐Wasowska   +13 more
openalex   +1 more source

Rapamycin: Drug Repurposing in SARS-CoV-2 Infection [PDF]

, 2021
Jiří Patočka, Kamil Kuča, Patrik Olekšák, Eugenie Nepovimová, Martin Vališ, Michal Novotný, Blanka Klímová   +6 more
openalex   +1 more source

CD147/Basigin: From Integrative Molecular Hub to Translational Therapeutic Target

Advanced Science, EarlyView.
This review conceptualizes CD147 as a fundamental “Energy‐Structure Coupler,” physically bridging metabolic flux (via MCTs) with morphogenetic plasticity (via integrins/MMPs) to drive cancer, infection, and autoimmunity. Addressing the “specificity paradox” that limits current translation, the authors chart a strategic roadmap—spanning logic‐gated ...
Xiang‐Min Yang, Huijie Bian, Zhi‐Nan Chen   +2 more
wiley   +1 more source

Transcriptomics- and Genomics-Guided Drug Repurposing for the Treatment of Vesicular Hand Eczema

Pharmaceutics
Vesicular hand eczema (VHE), a clinical subtype of hand eczema (HE), showed limited responsiveness to alitretinoin, the only approved systemic treatment for severe chronic HE. This emphasizes the need for alternative treatment approaches.
Fieke M. Rosenberg, Zoha Kamali, Angelique N. Voorberg, Thijs H. Oude Munnink, Peter J. van der Most, Harold Snieder, Ahmad Vaez, Marie L. A. Schuttelaar   +7 more
doaj   +1 more source

Macrophage–Derived Ferritin Exacerbates Silica‐Induced Pulmonary Fibrosis via PIK3R2‐Mediated Fibroblast Differentiation

Advanced Science, EarlyView.
This study identifies ferritin as a pivotal mediator of silica‐induced pulmonary fibrosis. Macrophage‐derived ferritin drives fibroblast‐to‐myofibroblast differentiation via the PIK3R2/SMAD pathway, while ferritin knockdown alleviates fibrosis. These findings define ferritin as both a biomarker and pathogenic driver, highlighting ferritin‐PIK3R2 ...
Liqun Wang, Xuxi Chen, Hongying Quan, Rui Qian, Shuyu Gong, Qiurong He, Ying Gao, Ajia Axi, Manyu Zhao, Qin Zhang, Ling Zhang, Lijun Peng, Xin Sun, Ben Zhang, Yuqin Yao   +14 more
wiley   +1 more source