Results 231 to 240 of about 3,841,835 (347)

An Overview of Drug Repurposing: Review Article

, 2019
Gargi Dey, Gargi Dey
openalex   +1 more source

PharmVar GeneFocus: NAT2—Genetic Variation and Updated Nomenclature

Clinical Pharmacology &Therapeutics, EarlyView.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the highly polymorphic human N‐acetyltransferase 2 (NAT2) gene. NAT2 metabolizes several clinically used drugs including isoniazid, hydralazine, amifampridine, procainamide, and sulfonamides such as dapsone, and also some highly carcinogenic arylamines.
Georgia Papanikolaou, Estella S. Poloni, José A.G. Agúndez, Raquel L.F. Teixeira, Erin C. Boone, Adalberto Rezende Santos, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Mariam R. Habil, Giannoulis Fakis, Rodney F. Minchin, David W. Hein, Sotiria Boukouvala, Andrea Gaedigk   +14 more
wiley   +1 more source

Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma. [PDF]

J Transl Med
Costantini S, Romeo I, Fanelli G, Roca MS, Gualtieri G, Bagnara P, Polo A, Di Gennaro E, Ortuso F, Alcaro S, Budillon A, Ciliberto G, Paggi MG, Abbruzzese C.   +13 more
europepmc   +1 more source

Learning Strategies from Nature's Blueprint to Cyclic Carbonate Synthesis

ChemSusChem, Volume 18, Issue 6, March 15, 2025.
The development of sustainable synthetic methods for cyclic carbonates draws inspiration from nature, focusing on eco‐friendly processes and renewable resources like CO2 and biomass. This review explore various CO2 activation mechanisms, green chemistry principles, and green catalysts.
Erika Saccullo, Vincenzo Patamia, Chiara Zagni, Antonio Rescifina, Giuseppe Floresta   +4 more
wiley   +1 more source

Drug Repurposing for Targeting Cancer Stem-like Cells in Glioblastoma. [PDF]

Cancers (Basel)
De Sousa-Coelho AL, Solaković B, Bento AD, Fernandes MT.   +3 more
europepmc   +1 more source

Repurposing drugs to advance the treatment of Buruli ulcer

Sanjay Singh, Rie Yotsu, Eric L. Nuermberger, Shashikant Srivastava   +3 more
openalex   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Overcoming barriers to off-patent drug repurposing: a lifecycle-based policy solutions. [PDF]

Front Pharmacol
Garcia-Diaz M, Epstein D, Espin J.
europepmc   +1 more source

Rephetio: Repurposing drugs on a hetnet [project]

, 2015
Daniel Himmelstein, Antoine Lizée, Chrissy Hessler, Leo Brueggeman, Sabrina Chen, Dexter Hadley, Ari Green, Pouya Khankhanian, Sergio E. Baranzini   +8 more
openalex   +1 more source