Results 21 to 30 of about 3,841,835 (347)
A data-driven methodology towards evaluating the potential of drug repurposing hypotheses
Computational and Structural Biotechnology Journal, 2021 Drug repurposing has become a widely used strategy to accelerate the process of finding treatments. While classical de novo drug development involves high costs, risks, and time-consuming paths, drug repurposing allows to reuse already-existing and ...
Lucía Prieto Santamaría +5 more
doaj +1 more source
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Cell Discovery, 2020 Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality.
Yadi Zhou +5 more
semanticscholar +1 more source
Deep learning for drug repurposing: Methods, databases, and applications [PDF]
WIREs Computational Molecular Science, 2022 Drug development is time‐consuming and expensive. Repurposing existing drugs for new therapies is an attractive solution that accelerates drug development at reduced experimental costs, specifically for Coronavirus Disease 2019 (COVID‐19), an infectious ...
Xiao Pan +7 more
semanticscholar +1 more source
Considerations and challenges for sex-aware drug repurposing
Biology of Sex Differences, 2022 Highlights Genetic, epigenetic, hormonal, immunological, metabolic, and environmental factors affect sex-biased drug responses. Drug repurposing approaches provide a significant advantage over novel drug development by reducing lengthy and costly ...
Jennifer L. Fisher +5 more
doaj +1 more source
Pharmaceutics, 2021 Drug repurposing is a valuable alternative to traditional drug design based on the assumption that medicines have multiple functions. Computer-based techniques use ever-growing drug databases to uncover new drug repurposing hints, which require further ...
Vlad Groza +3 more
doaj +1 more source
Systematic polypharmacology and drug repurposing via an integrated L1000-based Connectivity Map database mining [PDF]
Royal Society Open Science, 2018 Drug repurposing aims to find novel indications of clinically used or experimental drugs. Because drug data already exist, drug repurposing may save time and cost, and bypass safety concerns.
Tsang-Pai Liu +3 more
doaj +1 more source
Network Crosstalk as a Basis for Drug Repurposing
Frontiers in Genetics, 2022 The need for systematic drug repurposing has seen a steady increase over the past decade and may be particularly valuable to quickly remedy unexpected pandemics. The abundance of functional interaction data has allowed mapping of substantial parts of the
Dimitri Guala +2 more
doaj +1 more source
Buying time: Drug repurposing to treat the host in COVID‐19H
Pharmacology Research & Perspectives, 2020 In 2016 Fedson stated …. “For almost two decades, leading scientists and health officials have warned that we must prepare for a potentially devastating global pandemic of an infectious disease. Initial concern was focused on …H5N1….
Jennifer H. Martin +2 more
doaj +1 more source
Clinical Epigenetics, 2023 Background N-methyl-2-pyrrolidone (NMP) is an epigenetically active chemical fragment and organic solvent with numerous applications including use as a drug-delivery vehicle. Previously considered biologically inert, NMP demonstrates immunomodulatory and
Jake Shortt +8 more
doaj +1 more source
Drug Repurposing: An Effective Tool in Modern Drug Discovery
Russian journal of bioorganic chemistry, 2023 Drug repurposing is using an existing drug for a new treatment that was not indicated before. It has received immense attention during the COVID-19 pandemic emergency.
V. Kulkarni +4 more
semanticscholar +1 more source