Results 21 to 30 of about 3,896,424 (394)
Cells, 2022 Glioblastoma is a highly aggressive, invasive and treatment-resistant tumour. The DNA damage response (DDR) provides tumour cells with enhanced ability to activate cell cycle arrest and repair treatment-induced DNA damage.
Mathew Lozinski +6 more
doaj +1 more source
A Path to Real-World Evidence in Critical Care Using Open-Source Data Harmonization Tools
Critical Care Explorations, 2023 COVID-19 highlighted the need for use of real-world data (RWD) in critical care as a near real-time resource for clinical, research, and policy efforts.
Smith F. Heavner, PhD, RN +11 more
doaj +1 more source
BMC Cancer, 2022 Background Platinum chemoresistance results in high-grade serous ovarian cancer (HGSOC) disease recurrence. Recent treatment advances using checkpoint inhibitor immunotherapy has not benefited platinum-resistant HGSOC.
Michelle W. Wong-Brown +2 more
doaj +1 more source
Pharmacology Research & Perspectives, 2021 Trial data support an absence of an exposure–survival relationship for pembrolizumab. As these relationships remain unexamined in a real‐world setting, we determined them in metastatic melanoma prospectively in an observational study.
Vishal Navani +5 more
doaj +1 more source
A SARS-CoV-2 Protein Interaction Map Reveals Targets for Drug-Repurposing
Nature, 2020 A newly described coronavirus named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which is the causative agent of coronavirus disease 2019 (COVID-19), has infected over 2.3 million people, led to the death of more than 160,000 individuals
D. Gordon +124 more
semanticscholar +1 more source
Repurposing Drugs via Network Analysis: Opportunities for Psychiatric Disorders
Pharmaceutics, 2022 Despite advances in pharmacology and neuroscience, the path to new medications for psychiatric disorders largely remains stagnated. Drug repurposing offers a more efficient pathway compared with de novo drug discovery with lower cost and less risk ...
Trang T. T. Truong +3 more
doaj +1 more source
A data-driven methodology towards evaluating the potential of drug repurposing hypotheses
Computational and Structural Biotechnology Journal, 2021 Drug repurposing has become a widely used strategy to accelerate the process of finding treatments. While classical de novo drug development involves high costs, risks, and time-consuming paths, drug repurposing allows to reuse already-existing and ...
Lucía Prieto Santamaría +5 more
doaj +1 more source
A brief overview of current drug repurposing approaches for COVID-19 management [PDF]
, 2020 This brief overview is intended to shed light on the current drug repositioning (also called drug repurposing) in the therapeutics of the novel coronavirus disease which emerged in 2019 (COVID-19).
Rodrigues, Pedro da Fonseca Soares +1 more
core +2 more sources
Network-based drug repurposing for novel coronavirus 2019-nCoV/SARS-CoV-2
Cell Discovery, 2020 Human coronaviruses (HCoVs), including severe acute respiratory syndrome coronavirus (SARS-CoV) and 2019 novel coronavirus (2019-nCoV, also known as SARS-CoV-2), lead global epidemics with high morbidity and mortality.
Yadi Zhou +5 more
semanticscholar +1 more source
Deep learning for drug repurposing: Methods, databases, and applications [PDF]
WIREs Computational Molecular Science, 2022 Drug development is time‐consuming and expensive. Repurposing existing drugs for new therapies is an attractive solution that accelerates drug development at reduced experimental costs, specifically for Coronavirus Disease 2019 (COVID‐19), an infectious ...
Xiao Pan +7 more
semanticscholar +1 more source