Results 61 to 70 of about 3,896,275 (257)
Pharmacology Research & PerspectivesCancer medicines often have narrow therapeutic windows; toxicity can be severe and sometimes fatal, but inadequate dose intensity reduces efficacy and survival.
Jennifer H. Martin +3 more
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Scientific Reports, 2023 The search for an effective drug is still urgent for COVID-19 as no drug with proven clinical efficacy is available. Finding the new purpose of an approved or investigational drug, known as drug repurposing, has become increasingly popular in recent ...
M. Islam +5 more
semanticscholar +1 more source
Breaking the paradigm: Dr Insight empowers signature-free, enhanced drug repurposing [PDF]
, 2019 Motivation: Transcriptome-based computational drug repurposing has attracted considerable interest by bringing about faster and more cost-effective drug discovery.
Baldwin, Nicole E. +4 more
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On the integration of in silico drug design methods for drug repurposing [PDF]
, 2017 Drug repurposing has become an important branch of drug discovery. Several computational approaches that help to uncover new repurposing opportunities and aid the discovery process have been put forward, or adapted from previous applications. A number of
Chen, Hongming +6 more
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DeCoST: A New Approach in Drug Repurposing From Control System Theory
Frontiers in Pharmacology, 2018 In this paper, we propose DeCoST (Drug Repurposing from Control System Theory) framework to apply control system paradigm for drug repurposing purpose.
Thanh M. Nguyen +6 more
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Antibiotics, 2020 Control of fungal pathogens is increasingly problematic due to the limited number of effective drugs available for antifungal therapy. Conventional antifungal drugs could also trigger human cytotoxicity associated with the kidneys and liver, including ...
Jong H. Kim +7 more
doaj +1 more source
npj Digital MedicineDrug repurposing represents an attractive alternative to the costly and time-consuming process of new drug development, particularly for serious, widespread conditions with limited effective treatments, such as Alzheimer’s disease (AD).
Chao Yan +11 more
semanticscholar +1 more source
Identification of Trypanosoma cruzi Polyamine Transport Inhibitors by Computational Drug Repurposing [PDF]
, 2019 Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. In T. cruzi the transport of polyamines is essential because this organism is unable to synthesize these compounds de novo.
Martínez Sayé, Melisa Soledad +5 more
core +1 more source
Artificial intelligence in COVID-19 drug repurposing
The Lancet: Digital Health, 2020 Summary: Drug repurposing or repositioning is a technique whereby existing drugs are used to treat emerging and challenging diseases, including COVID-19.
Yadi Zhou, PhD +4 more
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BMC MedicineBackground There is a lack of effective therapeutic strategies for amyotrophic lateral sclerosis (ALS); therefore, drug repurposing might provide a rapid approach to meet the urgent need for treatment.
Qingqing Duan +10 more
semanticscholar +1 more source