Results 61 to 70 of about 3,896,424 (394)

Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment [PDF]

open access: yes, 2020
BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant
Dufès, Christine   +9 more
core   +3 more sources

A machine learning and network framework to discover new indications for small molecules.

open access: yesPLoS Computational Biology, 2020
Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g.
Coryandar Gilvary   +5 more
doaj   +1 more source

Drug Repurposing for Rare Orphan Diseases Using Machine Learning Techniques

open access: yesProceedings of the International Florida Artificial Intelligence Research Society Conference, 2022
New drug discovery is a time-consuming and costly process. Several drugs have been in clinical trials for a very long period. Finding a new target for existing medications can be an effective strategy to reduce the lengthy and costly drug development ...
Rajesh Manicavasaga   +3 more
doaj   +1 more source

Decoding Connectivity Map-based drug repurposing for oncotherapy

open access: yesBriefings Bioinform., 2023
The rising global burden of cancer has driven considerable efforts into the research and development of effective anti-cancer agents. Fortunately, with impressive advances in transcriptome profiling technology, the Connectivity Map (CMap) database has ...
Yuanchun Zhao   +3 more
semanticscholar   +1 more source

Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer. [PDF]

open access: yes, 2017
Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown.
Barrett, John W   +17 more
core   +1 more source

A Maximum Flow-Based Approach to Prioritize Drugs for Drug Repurposing of Chronic Diseases

open access: yesLife, 2021
The discovery of new drugs is required in the time of global aging and increasing populations. Traditional drug development strategies are expensive, time-consuming, and have high risks.
Md. Mohaiminul Islam   +2 more
doaj   +1 more source

Drug Repurposing of Generic Drugs: Challenges and the Potential Role for Government

open access: yesApplied Health Economics and Health Policy, 2023
Drug repurposing is the process of identifying a new use for an existing drug or active substance in an indication outside the scope of the original indication.
K. H. van der Pol   +6 more
semanticscholar   +1 more source

Old Drugs, New Indications (Review)

open access: yesРазработка и регистрация лекарственных средств, 2023
Introduction. The drug can be used in the treatment of one disease and for the prevention and treatment of another pathological process. This is possible due to the repurposing of medicines.
I. I. Miroshnichenko   +2 more
doaj   +1 more source

A novel drug repurposing approach for non-small cell lung cancer using deep learning.

open access: yesPLoS ONE, 2020
Drug repurposing is an attractive and pragmatic way offering reduced risks and development time in the complicated process of drug discovery. In the past, drug repurposing has been largely accidental and serendipitous. The most successful examples so far
Bingrui Li   +6 more
doaj   +1 more source

Drug Repurposing in Non-Small Cell Lung Carcinoma: Old Solutions for New Problems

open access: yesCurrent Oncology, 2023
Lung cancer is the second most common cancer and the leading cause of cancer-related deaths in 2022. The majority (80%) of lung cancer cases belong to the non-small cell lung carcinoma (NSCLC) subtype.
George Doumat   +6 more
semanticscholar   +1 more source

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