Repurposing screen identifies mebendazole as a clinical candidate to synergise with docetaxel for prostate cancer treatment [PDF]
, 2020 BACKGROUND: Docetaxel chemotherapy in prostate cancer has a modest impact on survival. To date, efforts to develop combination therapies have not translated into new treatments. We sought to develop a novel therapeutic strategy to tackle chemoresistant
Dufès, Christine +9 more
core +3 more sources
A machine learning and network framework to discover new indications for small molecules.
PLoS Computational Biology, 2020 Drug repurposing, identifying novel indications for drugs, bypasses common drug development pitfalls to ultimately deliver therapies to patients faster. However, most repurposing discoveries have been led by anecdotal observations (e.g.
Coryandar Gilvary +5 more
doaj +1 more source
Drug Repurposing for Rare Orphan Diseases Using Machine Learning Techniques
Proceedings of the International Florida Artificial Intelligence Research Society Conference, 2022 New drug discovery is a time-consuming and costly process. Several drugs have been in clinical trials for a very long period. Finding a new target for existing medications can be an effective strategy to reduce the lengthy and costly drug development ...
Rajesh Manicavasaga +3 more
doaj +1 more source
Decoding Connectivity Map-based drug repurposing for oncotherapy
Briefings Bioinform., 2023 The rising global burden of cancer has driven considerable efforts into the research and development of effective anti-cancer agents. Fortunately, with impressive advances in transcriptome profiling technology, the Connectivity Map (CMap) database has ...
Yuanchun Zhao +3 more
semanticscholar +1 more source
Repurposing Albendazole: new potential as a chemotherapeutic agent with preferential activity against HPV-negative head and neck squamous cell cancer. [PDF]
, 2017 Albendazole is an anti-helminthic drug that has been shown to exhibit anti-cancer properties, however its activity in head and neck squamous cell cancer (HNSCC) was unknown.
Barrett, John W +17 more
core +1 more source
A Maximum Flow-Based Approach to Prioritize Drugs for Drug Repurposing of Chronic Diseases
Life, 2021 The discovery of new drugs is required in the time of global aging and increasing populations. Traditional drug development strategies are expensive, time-consuming, and have high risks.
Md. Mohaiminul Islam +2 more
doaj +1 more source
Drug Repurposing of Generic Drugs: Challenges and the Potential Role for Government
Applied Health Economics and Health Policy, 2023 Drug repurposing is the process of identifying a new use for an existing drug or active substance in an indication outside the scope of the original indication.
K. H. van der Pol +6 more
semanticscholar +1 more source
Old Drugs, New Indications (Review)
Разработка и регистрация лекарственных средств, 2023 Introduction. The drug can be used in the treatment of one disease and for the prevention and treatment of another pathological process. This is possible due to the repurposing of medicines.
I. I. Miroshnichenko +2 more
doaj +1 more source
A novel drug repurposing approach for non-small cell lung cancer using deep learning.
PLoS ONE, 2020 Drug repurposing is an attractive and pragmatic way offering reduced risks and development time in the complicated process of drug discovery. In the past, drug repurposing has been largely accidental and serendipitous. The most successful examples so far
Bingrui Li +6 more
doaj +1 more source
Drug Repurposing in Non-Small Cell Lung Carcinoma: Old Solutions for New Problems
Current Oncology, 2023 Lung cancer is the second most common cancer and the leading cause of cancer-related deaths in 2022. The majority (80%) of lung cancer cases belong to the non-small cell lung carcinoma (NSCLC) subtype.
George Doumat +6 more
semanticscholar +1 more source