Results 81 to 90 of about 3,896,424 (394)

Light‐Responsive Enzyme‐Loaded Nanoparticles for Tunable Adhesion and Mechanical Wound Contraction

Advanced Functional Materials, EarlyView.
This study presents a photoactivatable enzyme‐loaded mesoporous nanoparticle system (MPDA_PaTy) that enables light‐triggered tunable tissue adhesion and facilitates mechanical wound contraction. Controlled enzymatic crosslinking at tissue or hydrogel interfaces allows on‐demand adhesion.
Junghyeon Ko, Hyeon‐Jin Kim, Jeong‐Uk Kim, Seh Ri Oh, Tae Hoon Kang, Junghwan Byun, Uk‐Jae Lee, Minglin Ma, Su‐Hwan Kim, Byung‐Gee Kim, Nathaniel S. Hwang   +10 more
wiley   +1 more source

Drug repurposing: a systematic review on root causes, barriers and facilitators

BMC Health Services Research, 2022
Background Repurposing is a drug development strategy receiving heightened attention after the Food and Drug Administration granted emergency use authorization of several repurposed drugs to treat Covid-19. There remain knowledge gaps on the root causes,
Nithya Krishnamurthy, A. Grimshaw, S. Axson, Sung Hee Choe, Jennifer E. Miller   +4 more
semanticscholar   +1 more source

Disruptive Strategies for Removing Drug Discovery Bottlenecks [PDF]

, 2012
Drug Discovery is shifting focus from the industry to outside partners and in the process creating new bottlenecks, suggesting the need for a more disruptive overhaul.
Antony Williams, Chris Waller, Mary Bradley, Sean Ekins, Sean Ekins   +4 more
core   +2 more sources

Novel Functional Materials via 3D Printing by Vat Photopolymerization

Advanced Functional Materials, EarlyView.
This Perspective systematically analyzes strategies for incorporating functionalities into 3D‐printed materials via Vat Photopolymerization (VP). It explores the spectrum of achievable functionalities in recently reported novel materials—such as conductive, energy‐storing, biodegradable, stimuli‐responsive, self‐healing, shape‐memory, biomaterials, and
Sergey S. Nechausov, Patrick Fesser, Boris A. Bulgakov, Ulrich S. Schubert   +3 more
wiley   +1 more source

Targeting Inflammation in Non-Small Cell Lung Cancer through Drug Repurposing

Pharmaceuticals, 2023
Lung cancer is the most common cause of cancer-related deaths. Lung cancers can be classified as small-cell (SCLC) or non-small cell (NSCLC). About 84% of all lung cancers are NSCLC and about 16% are SCLC. For the past few years, there have been a lot of
T. Rajasegaran, C. W. How, Anoosha Saud, Azhar Ali, Jonathan Chee Woei Lim   +4 more
semanticscholar   +1 more source

Setting a research agenda for progressive multiple sclerosis: The International Collaborative on Progressive MS [PDF]

, 2012
Despite significant progress in the development of therapies for relapsing MS, progressive MS remains comparatively disappointing. Our objective, in this paper, is to review the current challenges in developing therapies for progressive MS and identify ...
Baker, D, Baneke, P, Brown, D, Browne, P, Chandraratna, D, Ciccarelli, O, Coetzee, T, Comi, G, Feinstein, A, Fox, RJ, Kapoor, R, Lee, K, Salvetti, M, Sharrock, K, Thompson, A, Toosy, A, Zaratin, P, Zuidwijk, K   +17 more
core   +2 more sources

Drug repurposing in cancer

Pharmacological Research, 2017
Cancer is a major health issue worldwide, and the global burden of cancer is expected to increase in the coming years. Whereas the limited success with current therapies has driven huge investments into drug development, the average number of FDA approvals per year has declined since the 1990s.
Linda, Sleire, Hilde Elise, Førde, Inger Anne, Netland, Lina, Leiss, Bente Sandvei, Skeie, Per Øyvind, Enger   +5 more
openaire   +2 more sources

Metal–Organic Frameworks for Gaseous Pollutant Management: From Capture to Neutralization and Reutilization

Advanced Functional Materials, EarlyView.
This review maps how MOFs can manage hazardous gases by combining adsorption, neutralization, and reutilization, enabling sustainable air‐pollution control. Covering chemical warfare agent simulants, SO2, NOx, NH3, H2S, and volatile organic compounds, it highlights structure‐guided strategies that boost selectivity, water tolerance, and cycling ...
Yuanmeng Tian, Zeyu Tao, Kaikai Ma, Xiaoliang Wang, Bo Yu, Yiu Wan Yip, Zhijie Chen, Jin Shang, Bin Fei   +8 more
wiley   +1 more source

A Unified Explanation for Drug Repurposing and Pharmacological Pleiotropy Based on Classical and Statistical Thermodynamics

Pharmacology Research & Perspectives
Drug repurposing is an authentic, emerging, and growing aspect of drug development when the demand for new therapeutic solutions is high. Many repurposed drugs have been discovered by serendipity or a non‐ordered process driven by chance and sharp ...
Richard Head, Saiful Islam, Jennifer H. Martin   +2 more
doaj   +1 more source

Drug Repurposing for Cancer Treatment: A Comprehensive Review

International Journal of Molecular Sciences
Cancer ranks among the primary contributors to global mortality. In 2022, the global incidence of new cancer cases reached about 20 million, while the number of cancer-related fatalities reached 9.7 million.
Abdulaziz H. Al Khzem, Mohammed Gomaa, Mansour S. Alturki, Nada Tawfeeq, Mohammad Sarafroz, Shareefa M. Alonaizi, Alhassan Al Faran, Laela Ahmed Alrumaihi, Fatimah AlAnsari, Abdullah Abbas Alghamdi   +9 more
semanticscholar   +1 more source