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Human Fungal Pathogens and Drug Resistance Against Azole Drugs
2017Pathogenic fungi causing severe infections in humans with immunocompromised immune system have been the major reasons of deaths in the world. Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus are among the most prevalent human fungal pathogens. The most widely used therapy used for the invasive fungal infections is the treatment with
Preetida J. Bhetariya +5 more
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Role of Mitochondria in Fungal Drug Resistance
2019Incidences of opportunistic fungal infections and related mortality are growing threats to immunosuppressed patients. Limited arsenal in form of antifungals, along with emerging resistance, their toxicity and efficacy are the bottlenecks in successful treatment.
Ritu Pasrija, Deepika Kundu
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Pathogenesis of Fungal Infections and Drug-Resistance Phenomenon
2020Fungi the primitive eukaryotes are emerging as life-threatening pathogens of public health. Over a decade and ago, the frequency of fungal infections has been enormous, with an increased range of mortality and morbidity in immunocompromised patients.
Sudhakar Pola +3 more
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Fungal ATP-Binding Cassette (ABC) Transporters in Drug Resistance & Detoxification
Current Drug Targets, 2006Pleiotropic drug resistance (PDR) is a well-described phenomenon occurring in fungi. PDR shares several similarities with processes in bacteria and higher eukaryotes. In mammalian cells, multidrug resistance (MDR) develops from an initial single drug resistance, eventually leading to a broad cross-resistance to many structurally and functionally ...
György, Sipos, Karl, Kuchler
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Beyond resistance: antifungal heteroresistance and antifungal tolerance in fungal pathogens.
Current Opinion in MicrobiologyFungal infections are increasing globally, causing alarmingly high mortality and economic burden. In addition to antifungal resistance, other more subtle drug responses appear to increase the likelihood of treatment failures.
Feng Yang, J. Berman
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Fungal ABC proteins: pleiotropic drug resistance, stress response and cellular detoxification
Research in Microbiology, 2001A number of prominent genetic diseases are caused by mutations in genes encoding ATP-binding cassette (ABC) proteins (Ambudkar, Gottesmann, 1998). Moreover, several mammalian ABC proteins such as P-glycoprotein (P-gp) (Gottesman et al., 1995) and multidrug-resistance-associated proteins (MRPs) (Cole, Deeley, 1998) have been implicated in multidrug ...
H, Wolfger, Y M, Mamnun, K, Kuchler
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
exaly
- Molecular Characterization of Fungal Drug Resistance
2011Maurizio Sanguinetti +2 more
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