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Journal of Medicinal Chemistry, 2022
The high mortality rate of invasive fungal infections and quick emergence of drug-resistant fungal pathogens urgently call for potent antifungal agents. Inspired by the cell penetrating peptide (CPP) octaarginine (R8), we elongated to 28 residues poly(d ...
Yueming Wu +15 more
semanticscholar +1 more source
The high mortality rate of invasive fungal infections and quick emergence of drug-resistant fungal pathogens urgently call for potent antifungal agents. Inspired by the cell penetrating peptide (CPP) octaarginine (R8), we elongated to 28 residues poly(d ...
Yueming Wu +15 more
semanticscholar +1 more source
Resistance and tolerance mechanisms to antifungal drugs in fungal pathogens [PDF]
Mycologist, 2003 Fungal pathogens are using several mechanisms to circumvent the inhibitory actions of antifungal drugs. The variety of these mechanisms was revealed in recent years by several laboratories with molecular approaches. Besides the identification of genes involved in antifungal drug resistance and the discovery of alternative pathways of resistance (i.e ...
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Novel Strategiesto Combat the Emerging Drug Resistance in Human Pathogenic Microbes.
Current Drug Targets, 2020The major health-care burden for the developing world are the Infectious diseases and antimicrobial agents prove to be the magical drugs to combat this.
Hafsa Qadri, A. H. Shah, M. Mir
semanticscholar +1 more source
Human Fungal Pathogens and Drug Resistance Against Azole Drugs
2017Pathogenic fungi causing severe infections in humans with immunocompromised immune system have been the major reasons of deaths in the world. Candida albicans, Cryptococcus neoformans, and Aspergillus fumigatus are among the most prevalent human fungal pathogens. The most widely used therapy used for the invasive fungal infections is the treatment with
Santosh Kumar Upadhyay +5 more
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Biomimetic Nanopillared Surfaces Inhibit Drug Resistant Filamentous Fungal Growth
ACS Applied Bio Materials, 2019Filamentous fungi are invasive and multidrug resistant pathogens that commonly contaminate biomedical devices and implants. Once spherical fungal spores attach to a surface, they exhibit germ tube development, hyphal growth, and robust biofilm formation.
Rachel Rosenzweig +5 more
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Drug development challenges and strategies to address emerging and resistant fungal pathogens
Expert Review of Anti-infective Therapy, 2017Invasive fungal infections represent an expanding threat to public health. The recent emergence of Candida auris, which is often resistant to existing antifungal agents and is associated with a high mortality rate, underscores the urgent need for novel drug development strategies.
Thomas J. Walsh, Matthew W. McCarthy
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In the Crossroad Between Drug Resistance and Virulence in Fungal Pathogens
2018Fungal species from the Cryptococcus, Candida, and Aspergillus genera are recognized as important human pathogens, causing infections which are often deadly and extremely difficult to treat due to their ability to exhibit and develop antifungal resistance and virulence.
Miguel C. Teixeira, Mafalda Cavalheiro
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The evolution of fungal drug resistance: modulating the trajectory from genotype to phenotype
Nature Reviews Microbiology, 2008The emergence of drug resistance in pathogenic microorganisms provides an excellent example of microbial evolution that has had profound consequences for human health. The widespread use of antimicrobial agents in medicine and agriculture exerts strong selection for the evolution of drug resistance.
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Antibody–drug conjugates: Smart chemotherapy delivery across tumor histologies
Ca-A Cancer Journal for Clinicians, 2022Paolo Tarantino +2 more
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