Results 31 to 40 of about 346,859 (308)

Transcriptional response to the host cell environment of a multidrug-resistant Mycobacterium tuberculosis clonal outbreak Beijing strain reveals its pathogenic features

Scientific Reports, 2021
Tuberculosis is a global public health problem with emergence of multidrug-resistant infections. Previous epidemiological studies of tuberculosis in Thailand have identified a clonal outbreak multidrug-resistant strain of Mycobacterium tuberculosis in ...
Pakorn Aiewsakun, Pinidphon Prombutara, Tegar Adriansyah Putra Siregar, Thanida Laopanupong, Phongthon Kanjanasirirat, Tanawadee Khumpanied, Suparerk Borwornpinyo, Pirut Tong-Ngam, Alisa Tubsuwan, Prapaporn Srilohasin, Angkana Chaiprasert, Wuthiwat Ruangchai, Prasit Palittapongarnpim, Therdsak Prammananan, Brian C. VanderVen, Marisa Ponpuak   +15 more
doaj   +1 more source

Improved Network Performance via Antagonism: From Synthetic Rescues to Multi-drug Combinations [PDF]

, 2010
Recent research shows that a faulty or sub-optimally operating metabolic network can often be rescued by the targeted removal of enzyme-coding genes--the exact opposite of what traditional gene therapy would suggest.
Adilson E. Motter, Baba, Blagosklonny, Bollenbach, Bourgeois, Burgard, Burgard, Cagatay, Chait, Cun, Dancey, Duarte, Edwards, Feist, Fischer, Fong, Fong, Fong, Fong, Fraenkel, Gerdes, Giaever, Goebl, Harrison, Hashimoto, Hegreness, Henry, Herring, Hilgetag, Hilgetag, Hillenmeyer, Hopkins, Huttenlocher, Huttenlocher, Isalan, Kauffman, Keiser, Kim, Kitano, Kupiec, Ma, Miller, Motter, Motter, Nishikawa, Olson, Palsson, Papp, Pharkya, Reguly, Segre, Segre, Shlomi, Timmermans, Wagner, Yeh, Yildirim, Yngvadottir, Zamboni   +58 more
core   +3 more sources

Advancing Antimicrobial Resistance Research Through Quantitative Modeling and Synthetic Biology

Frontiers in Bioengineering and Biotechnology, 2020
Antimicrobial resistance (AMR) is an emerging global health crisis that is undermining advances in modern medicine and, if unmitigated, threatens to kill 10 million people per year worldwide by 2050.
Kevin S. Farquhar, Harold Flohr, Daniel A. Charlebois   +2 more
doaj   +1 more source

Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study. [PDF]

, 2019
Antimicrobial resistance (AMR) poses a threat to public health. Clinical microbiology laboratories typically rely on culturing bacteria for antimicrobial-susceptibility testing (AST).
Aller, SD, Bruchmann, S, Clark, T, Coello Pelegrin, A, Cormican, M, Diez Benavente, E, Doyle, RM, Ellington, MJ, Harris, KA, Huggett, JF, McGrath, E, Moran-Gilad, J, Motro, Y, O'Sullivan, DM, Phelan, J, Phuong Thuy Nguyen, T, Shaw, LP, Stabler, RA, van Belkum, A, van Dorp, L, Woodford, N   +20 more
core   +4 more sources

Altered Microbial Composition of Drug-Sensitive and Drug-Resistant TB Patients Compared with Healthy Volunteers [PDF]

Microorganisms, 2021
Mycobacterium tuberculosis infection has three discernible outcomes: active tuberculosis, latent tuberculosis, or clearance of the bacterium. The outcome of the infection depends on the interaction of the bacterium, the immune system, and the microbiome of the host.
Fernanda Valdez-Palomares, Marcela Muñoz Torrico, Berenice Palacios-González, Xavier Soberón, Eugenia Silva-Herzog   +4 more
openaire   +4 more sources

A review on lipid-based nanocarriers mimicking chylomicron and their potential in drug delivery and targeting infectious and cancerous diseases

AAPS Open, 2023
Infectious and cancerous diseases are tedious to manage. The problem of drug resistance is often associated with anti-microbial and anti-cancer agents and is one of the most significant challenges that restrict their activity.
Rana E. Elnady, Maha M. Amin, Mohamed Y. Zakaria   +2 more
doaj   +1 more source

Prevalence of Extended-Spectrum β-lactamase and Integron Gene Carriage in Multidrug-Resistant Klebsiella Species Isolated from Outpatients in Yazd, Iran [PDF]

Iranian Journal of Medical Sciences, 2020
Background: Community-acquired infections by multidrug-resistant (MDR), extended-spectrum β-lactamase (ESBL) producing Klebsiella species (Klebsiella spp.) is of major concern worldwide. Antibiotic resistance, production of extended-spectrum β-lactamases
Mohammad Reza Malekjamshidi, Hengameh Zandi, Fereshteh Eftekhar   +2 more
doaj   +1 more source

Global Status of Antimicrobial Resistance and Corresponding Therapeutic Strategies

Xiehe Yixue Zazhi
With the widespread use of antimicrobial agents, the issue of microbial drug resistance has become increasingly severe, emerging as a major global public health challenge.
XU Xuesong, WANG Yao
doaj   +1 more source

The mPEG-PCL Copolymer for Selective Fermentation of Staphylococcus lugdunensis Against Candida parapsilosis in the Human Microbiome. [PDF]

, 2016
Many human skin diseases, such as seborrheic dermatitis, potentially occur due to the over-growth of fungi. It remains a challenge to develop fungicides with a lower risk of generating resistant fungi and non-specifically killing commensal microbes.
Barshop, Bruce A, Chen, Wan-Tzu, Gallo, Richard L, Gangoiti, Jon A, Hsieh, Ming-Fa, Huang, Chun-Jen, Huang, Chun-Ming, Huang, Stephen, Hyun, Choi, Kao, Ming-Shan, Lee, Woan-Ruah, Lin, Wan-Zhen, Marito, Shinta, Ran, Yuping, Sanford, James A, Wang, Yanhan   +15 more
core   +1 more source

Anti-microbial Use in Animals: How to Assess the Trade-offs [PDF]

, 2015
Antimicrobials are widely used in preventive and curative medicine in animals. Benefits from curative use are clear – it allows sick animals to be healthy with a gain in human welfare.
Acar J. F., Codex Alimentarius, Cogliani C., Davies S., Graham J. P., J. Rushton, McEwen S. A., Pagel S. W., Rushton J., Rushton J., Steinfeld H., Tisdell C., Wegener H. C.   +12 more
core   +2 more sources