Results 11 to 20 of about 194,109 (247)

Multiple-Replicon Resistance Plasmids of Klebsiella Mediate Extensive Dissemination of Antimicrobial Genes

open access: yesFrontiers in Microbiology, 2021
Multiple-replicon resistance plasmids have become important carriers of resistance genes in Gram-negative bacteria, and the evolution of multiple-replicon plasmids is still not clear.
Xue Wang   +15 more
doaj   +1 more source

Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia [PDF]

open access: yesBMC Urology, 2021
Abstract Background The urinary stone and urinary tract infection (UTI) are invariably associated and are frequent causes of morbidity. Date on burden of UTI among urinary stone patients is lacking in Ethiopia. This study was aimed to assess bacterial profile, antimicrobial susceptibility and associated factors among ...
Feleke Moges   +4 more
openaire   +4 more sources

The evolution of resistance to synergistic multi‐drug combinations is more complex than evolving resistance to each individual drug component

open access: yesEvolutionary Applications, 2023
Multidrug antibiotic resistance is an urgent public health concern. Multiple strategies have been suggested to alleviate this problem, including the use of antibiotic combinations and cyclic therapies.
Natalie Ann Lozano‐Huntelman   +11 more
doaj   +1 more source

Isolation and characterization of multiple drug resistance bacterial pathogens from waste water in hospital and non-hospital environments, Northwest Ethiopia [PDF]

open access: yesBMC Research Notes, 2014
The importance of bacterial isolates from waste water environment as a reservoir of antibiotic resistance and a potential source of novel resistance genes to clinical pathogens is underestimated. This study is aimed at to isolate and characterize public health important bacteria from waste water in hospital and non- hospital environments and evaluate ...
Walelegn Worku   +4 more
openaire   +4 more sources

Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance

open access: yesmBio, 2022
Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting ...
Jees Sebastian   +8 more
doaj   +1 more source

Heavy metal tolerance and multiple drug resistance of heterotrophic bacterial isolates from metal contaminated soil [PDF]

open access: yesThe South Pacific Journal of Natural and Applied Sciences, 2012
The development of multiple metal/antibiotic resistances among the bacterial population causes a potential risk to human health. Metal contamination in natural environments could have an important role in the maintenance and proliferation of antibiotic resistance.
A. A. Mohamed Hatha   +2 more
openaire   +2 more sources

Etiology of Diarrhoea with Reference to Multiple Drug Resistant Enteric Bacterial Pathogens

open access: yesNepal Journal of Science and Technology, 1970
A total of 340 stool samples were processed and studied from both sexes including all ages of patients. Association of enteropathogens between male and female was not statistically significant. Incidence of diarrhoea (28.23%) as well as prevalence of enteropathogens (34.31%) was found highest in the age group (20-30) years.
Sirjana Devi Shrestha   +2 more
openaire   +3 more sources

Interplay in the selection of fluoroquinolone resistance and bacterial fitness. [PDF]

open access: yesPLoS Pathogens, 2009
Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA transcription by regulating chromosome supercoiling.
Linda L Marcusson   +2 more
doaj   +1 more source

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

open access: yeseLife, 2021
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat.
Claudia Igler, Jens Rolff, Roland Regoes
doaj   +1 more source

Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria

open access: yesFrontiers in Microbiology, 2021
There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has emerged from multiple screening efforts as a potential target for auranofin ...
LewisOscar Felix   +2 more
doaj   +1 more source

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