Results 31 to 40 of about 334,672 (303)

Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionMultiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization.
Di Wu, Di Wu, Yan Jia, Wenhao Cai, Wenhao Cai, Yilin Huang, Arjun Kattakayam, Diane Latawiec, Robert Sutton, Jie Peng   +9 more
openaire   +3 more sources

Multiple-Replicon Resistance Plasmids of Klebsiella Mediate Extensive Dissemination of Antimicrobial Genes

Frontiers in Microbiology, 2021
Multiple-replicon resistance plasmids have become important carriers of resistance genes in Gram-negative bacteria, and the evolution of multiple-replicon plasmids is still not clear.
Xue Wang, Xue Wang, Jianan Zhao, Fang Ji, Han Chang, Jiao Qin, Chenglin Zhang, Guocheng Hu, Jiayue Zhu, Jianchun Yang, Zhongxin Jia, Zhongxin Jia, Gang Li, Jianhua Qin, Bin Wu, Chengmin Wang   +15 more
doaj   +1 more source

The evolution of resistance to synergistic multi‐drug combinations is more complex than evolving resistance to each individual drug component

Evolutionary Applications, 2023
Multidrug antibiotic resistance is an urgent public health concern. Multiple strategies have been suggested to alleviate this problem, including the use of antibiotic combinations and cyclic therapies.
Natalie Ann Lozano‐Huntelman, Austin Bullivant, Jonathan Chacon‐Barahona, Alondra Valencia, Nick Ida, April Zhou, Pooneh Kalhori, Gladys Bello, Carolyn Xue, Sada Boyd, Colin Kremer, Pamela J. Yeh   +11 more
doaj   +1 more source

Multiple Drug Resistance Patterns in Various Phylogenetic Groups of Hospital-Acquired Uropathogenic E. coli Isolated from Cancer Patients

Antibiotics, 2020
Cancer patients are more susceptible to several bacterial infections, particularly urinary tract infections caused by uropathogenic E. coli (UPEC).
A. Mahmoud, Mohamed Taha Salim, R. Ibrahem, Adel Gabr, H. M. Halby   +4 more
semanticscholar   +1 more source

Virulence Factors of Pseudomonas Aeruginosa and Antivirulence Strategies to Combat Its Drug Resistance

Frontiers in Cellular and Infection Microbiology, 2022
Pseudomonas aeruginosa is an opportunistic pathogen causing nosocomial infections in severely ill and immunocompromised patients. Ubiquitously disseminated in the environment, especially in hospitals, it has become a major threat to human health due to ...
Chongbing Liao, Xin Huang, Qingxia Wang, Dan Yao, Wuyuan Lu   +4 more
semanticscholar   +1 more source

Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance

mBio, 2022
Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting ...
Jees Sebastian, Anooja Thomas, Carly Levine, Riju Shrestha, Shawn Levy, Hassan Safi, Sri Ram Pentakota, Pradeep Kumar, David Alland   +8 more
doaj   +1 more source

Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

Microbiology, 2023
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level. The treatment options against infections caused by multiple drug-resistant bacteria are shrinking gradually. The current pace of the discovery of new antibacterial
Amit Gaurav, Perwez Bakht, Mahak Saini, Shivam Pandey, R. Pathania   +4 more
semanticscholar   +1 more source

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

eLife, 2021
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat.
Claudia Igler, Jens Rolff, Roland Regoes
doaj   +1 more source

Interplay in the selection of fluoroquinolone resistance and bacterial fitness. [PDF]

PLoS Pathogens, 2009
Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA transcription by regulating chromosome supercoiling.
Linda L Marcusson, Niels Frimodt-Møller, Diarmaid Hughes   +2 more
doaj   +1 more source

Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia [PDF]

BMC Urology, 2021
Abstract Background The urinary stone and urinary tract infection (UTI) are invariably associated and are frequent causes of morbidity. Date on burden of UTI among urinary stone patients is lacking in Ethiopia. This study was aimed to assess bacterial profile, antimicrobial susceptibility and associated factors among ...
Desie Kasew, Setegn Eshetie, Abeje Diress, Zerubabiel Tegegne, Feleke Moges   +4 more
openaire   +3 more sources