Results 41 to 50 of about 237,994 (265)

Antibacterial activities of aqueous and methanol extracts of Nigella sativa on some multiple drug resistant diarrheic bacterial agents

Journal of Medicinal Botany, 2020
Combinations of various antimicrobial agents have been introduced as an extra successful strategy to combat multiple drug resistant infections. This study was undertaken to evaluate the effects of Nigella sativa seeds on several multi-drug resistant diarrheic bacterial agents.
Hassan Zainab Adewunmi, Adedayo Emmanuel Ogunware   +1 more
openaire   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

FEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace, Alyssa Borges, Charles Arnaud, Tove Karlsson, Nina K. Bröker, Stefanie Barbirz, Marta Bally   +6 more
wiley   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Editorial: Accelerating antibiotic development from natural products: tackling antimicrobial resistance (AMR)

Frontiers in Antibiotics
Graphical AbstractAccelerating antibiotic development from natural products. Natural products with antimicrobial activity can act through multiple mechanisms to overcome antibiotic resistance. These include directly inhibiting bacterial growth, reversing
Sanjib Bhakta, Cynthia Amaning Danquah, RuAngelie Edrada-Ebel, Simon Gibbons   +3 more
doaj   +1 more source

Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure

EBioMedicine, 2015
Current antibiotic testing does not include the potential influence of host cell environment on microbial susceptibility and antibiotic resistance, hindering appropriate therapeutic intervention.
Jessica Z. Kubicek-Sutherland, Douglas M. Heithoff, Selvi C. Ersoy, William R. Shimp, John K. House, Jamey D. Marth, Jeffrey W. Smith, Michael J. Mahan   +7 more
doaj   +1 more source

Rate and impact of duodenoscope contamination: A systematic review and meta-analysis

EClinicalMedicine, 2020
Background: Multiple infection outbreaks have been linked to contaminated duodenoscopes worldwide. However, the contamination rate of patient-ready duodenoscopes varies highly amongst published studies testing this subject.
Sara Larsen, Rasmus Vinther Russell, Lotte Klinten Ockert, Stephen Spanos, Helena Strømstad Travis, Lars Holger Ehlers, Anders Mærkedahl   +6 more
doaj   +1 more source

Microflora in patients with community-acquired pneumonia and hospital environment in Blagoveshchensk during pandemic

International Journal of Infectious Diseases, 2022
Purpose: An increase of community-acquired pneumonia (CAP) incidence has been detected during COVID-19 pandemic. Aim: to conduct analysis of bacterial microflora isolated from patients suffering from CAP and hospital environment in hospitals.
O. Kurganova, N. Pshenichnaya, E. Burdinskaya, Y. Natykan, O. Trotsenko, A. Bondarenko, V. Shmylenko, E. Bazykina   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source