Results 61 to 70 of about 334,672 (303)

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Time‐restricted feeding prior to Mycobacterium tuberculosis infection reduces tissue CD4+ T cells with limited impact on bacterial clearance

FEBS Open Bio, EarlyView.
Time‐restricted feeding (TRF) in mice increased liver fatty acid oxidation and decreased fatty acid biosynthesis. These alterations persisted when TRF was discontinued and the host was infected with Mycobacterium tuberculosis. Pre‐exposure to TRF did not alter tissue (lung and spleen) mycobacterial burden but significantly reduced CD3+ T cells in lungs
Ashish Gupta, Nidhi Yadav, Subhasmita Das, R. Rajendra Kumar Reddy, Nupur Sharma, Amol Ratnakar Suryawanshi, Jaswinder Singh Maras, Ranjan Kumar Nanda   +7 more
wiley   +1 more source

A Prediction Method for Animal-Derived Drug Resistance Trend Using a Grey-BP Neural Network Combination Model

Antibiotics, 2021
There is an increasing drug resistance of animal-derived pathogens, seriously posing a huge threat to the health of animals and humans. Traditional drug resistance testing methods are expensive, have low efficiency, and are time-consuming, making it ...
Xinxing Li, Ziyi Zhang, Ding Xu, Congming Wu, Jianping Li, Yongjun Zheng   +5 more
doaj   +1 more source

Isolation and Identification of Multiple Drug Resistant Bacterial Pathogens from Well Water Samples in and Around Wolaita Sodo Town, Southern Ethiopia

Journal of Drug Delivery and Therapeutics, 2021
Water for human consumption is required to be free from any bacteria that might pose a health risk. The worldwide prevalence of pathogen contamination is a serious concern, and enhancing the understanding of major pathogen sources and their significant impacts on water resources is crucial. Further, these organisms underwent multiple drug resistance in
Subramaniyan Vaithilingam, Krishna Moorthy Sivalingam   +1 more
openaire   +2 more sources

Emerging insights into CC and CXC chemokines and their receptors in Mycobacterium tuberculosis infection

FEBS Open Bio, EarlyView.
The dual roles of CC and CXC chemokines in distinguishing active, latent, and subclinical tuberculosis were reviewed, along with an evaluation of their potential as diagnostic biomarkers and therapeutic targets to advance precision medicine in tuberculosis management. The graphical abstract was generated with AI assistance (Gemini 3.0).
Xuying Yin, Dangsheng Xiao, Jiezuan Yang
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Antibacterial activities of aqueous and methanol extracts of Nigella sativa on some multiple drug resistant diarrheic bacterial agents

Journal of Medicinal Botany, 2020
Combinations of various antimicrobial agents have been introduced as an extra successful strategy to combat multiple drug resistant infections. This study was undertaken to evaluate the effects of Nigella sativa seeds on several multi-drug resistant diarrheic bacterial agents.
Hassan Zainab Adewunmi, Adedayo Emmanuel Ogunware   +1 more
openaire   +1 more source

Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance

Frontiers in Microbiology, 2018
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant microbes (or superbugs) are non-responsive to most of the commonly used
V. Shriram, T. Khare, R. Bhagwat, R. Shukla, Vinay Kumar   +4 more
semanticscholar   +1 more source

Coevolution of host-plasmid pairs facilitates the emergence of novel multi-drug resistance

Nature Ecology & Evolution, 2020
Multidrug resistance (MDR) of pathogens is an ongoing public health crisis exacerbated by the horizontal transfer of antibiotic resistance genes via conjugative plasmids.
Hannah Jordt, Thibault Stalder, Olivia Kosterlitz, J. Ponciano, E. Top, B. Kerr   +5 more
semanticscholar   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source