Results 61 to 70 of about 9,006,960 (303)

Multilabel hybridization probes for sequence-specific detection of sepsis-related drug resistance genes in plasmids

Talanta Open, 2021
Emerging antimicrobial drug resistance is increasing the complexity involved in treating critical conditions such as bacterial induced sepsis. Methods for diagnosing specific drug resistance tend to be rapid or sensitive, but not both.
Robert L. Hanson, Elaine Lazalde, Radim Knob, David H. Harris, Yesman Akuoko, Jacob B. Nielsen, Adam T. Woolley   +6 more
doaj   +1 more source

Characterisation of the vibrio cholerae antibiotic resistance var operon [PDF]

, 2007
The discovery and use of antibiotics in the chemotherapy of bacterial infections has revolutionised medicine as it is today. Unfortunately, the progressive use of antibiotics has promoted the evolution of bacterial defences against these mediators and ...
Massam-Wu, Teresa
core  

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Investigation of the intrinsic mechanism of drug resistance in multiple myeloma [PDF]

, 2011
The focus of this thesis was to evaluate the mechanisms whereby myeloma cells develop intrinsic resistance with a focus on resistance in the context of bortezomib treatment.
Ooi, Melissa
core   +1 more source

Editorial: Accelerating antibiotic development from natural products: tackling antimicrobial resistance (AMR)

Frontiers in Antibiotics
Graphical AbstractAccelerating antibiotic development from natural products. Natural products with antimicrobial activity can act through multiple mechanisms to overcome antibiotic resistance. These include directly inhibiting bacterial growth, reversing
Sanjib Bhakta, Cynthia Amaning Danquah, RuAngelie Edrada-Ebel, Simon Gibbons   +3 more
doaj   +1 more source

Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure

EBioMedicine, 2015
Current antibiotic testing does not include the potential influence of host cell environment on microbial susceptibility and antibiotic resistance, hindering appropriate therapeutic intervention.
Jessica Z. Kubicek-Sutherland, Douglas M. Heithoff, Selvi C. Ersoy, William R. Shimp, John K. House, Jamey D. Marth, Jeffrey W. Smith, Michael J. Mahan   +7 more
doaj   +1 more source

Rate and impact of duodenoscope contamination: A systematic review and meta-analysis

EClinicalMedicine, 2020
Background: Multiple infection outbreaks have been linked to contaminated duodenoscopes worldwide. However, the contamination rate of patient-ready duodenoscopes varies highly amongst published studies testing this subject.
Sara Larsen, Rasmus Vinther Russell, Lotte Klinten Ockert, Stephen Spanos, Helena Strømstad Travis, Lars Holger Ehlers, Anders Mærkedahl   +6 more
doaj   +1 more source

Microflora in patients with community-acquired pneumonia and hospital environment in Blagoveshchensk during pandemic

International Journal of Infectious Diseases, 2022
Purpose: An increase of community-acquired pneumonia (CAP) incidence has been detected during COVID-19 pandemic. Aim: to conduct analysis of bacterial microflora isolated from patients suffering from CAP and hospital environment in hospitals.
O. Kurganova, N. Pshenichnaya, E. Burdinskaya, Y. Natykan, O. Trotsenko, A. Bondarenko, V. Shmylenko, E. Bazykina   +7 more
doaj   +1 more source

Rapid microarray-based method for monitoring of all currently known single-nucleotide polymorphisms associated with parasite resistance to antimalaria drugs. [PDF]

, 2007
Parasite drug resistance is partly conferred by single-nucleotide polymorphisms (SNPs), and monitoring them has been proposed as an alternative to monitoring drug resistance.
Regös, Attila, Beck, Hans-Peter, Puijalon, Odile, Huber, E., Crameri, A., Regos, A., Crameri, Andreas, Mugittu, K., Felger, Ingrid, Sismeiro, Odile, Laubscher, Daniel, Marfurt, J., Genton, B., Laubscher, D., Puijalon, O., Felger, I., Burki, Richard, Beck, H. P., Coppee, Jean Yves, Genton, Blaise, Maire, N., Coppee, J. Y., Marfurt, Jutta, Mugittu, Kefas, Maire, Nicolas, Burki, R., Huber, Eric, Sismeiro, O.   +27 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source