Results 21 to 30 of about 431,274 (302)

Impact of multiple drug-resistant Gram-negative bacterial bacteraemia on infected pancreatic necrosis patients

Frontiers in Cellular and Infection Microbiology, 2022
IntroductionMultiple drug-resistant Gram-negative bacterial (MDR-GNB) bacteraemia poses a serious threat to patients in hospital. Infected pancreatic necrosis (IPN) patients are a vulnerable population to infectious complications during hospitalization.
Di Wu, Di Wu, Yan Jia, Wenhao Cai, Wenhao Cai, Yilin Huang, Arjun Kattakayam, Diane Latawiec, Robert Sutton, Jie Peng   +9 more
openaire   +3 more sources

A study of bacterial pathogens obtained from various samples in a tertiary care hospital and their antimicrobial susceptibility patterns

Journal of Clinical and Scientific Research, 2020
Background: Antimicrobial resistance (AMR) is of great concern in recent years as it is posing a global threat. The present study was undertaken to identify the prevalence of common bacterial isolates and their antimicrobial susceptibility patterns and ...
N Ramakrishna, R Jayaprada, K K Sharma, S Yamini, V S Srikala   +4 more
doaj   +1 more source

Multiple-Replicon Resistance Plasmids of Klebsiella Mediate Extensive Dissemination of Antimicrobial Genes

Frontiers in Microbiology, 2021
Multiple-replicon resistance plasmids have become important carriers of resistance genes in Gram-negative bacteria, and the evolution of multiple-replicon plasmids is still not clear.
Xue Wang, Xue Wang, Jianan Zhao, Fang Ji, Han Chang, Jiao Qin, Chenglin Zhang, Guocheng Hu, Jiayue Zhu, Jianchun Yang, Zhongxin Jia, Zhongxin Jia, Gang Li, Jianhua Qin, Bin Wu, Chengmin Wang   +15 more
doaj   +1 more source

The evolution of resistance to synergistic multi‐drug combinations is more complex than evolving resistance to each individual drug component

Evolutionary Applications, 2023
Multidrug antibiotic resistance is an urgent public health concern. Multiple strategies have been suggested to alleviate this problem, including the use of antibiotic combinations and cyclic therapies.
Natalie Ann Lozano‐Huntelman, Austin Bullivant, Jonathan Chacon‐Barahona, Alondra Valencia, Nick Ida, April Zhou, Pooneh Kalhori, Gladys Bello, Carolyn Xue, Sada Boyd, Colin Kremer, Pamela J. Yeh   +11 more
doaj   +1 more source

Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance

mBio, 2022
Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting ...
Jees Sebastian, Anooja Thomas, Carly Levine, Riju Shrestha, Shawn Levy, Hassan Safi, Sri Ram Pentakota, Pradeep Kumar, David Alland   +8 more
doaj   +1 more source

Multistrain models predict sequential multidrug treatment strategies to result in less antimicrobial resistance than combination treatment [PDF]

, 2016
Background Combination treatment is increasingly used to fight infections caused by bacteria resistant to two or more antimicrobials. While multiple studies have evaluated treatment strategies to minimize the emergence of resistant strains for single ...
Ahmad, Amais, Christiansen, Lasse Engbo, Græsbøll, Kaare, Matthews, Louise, Nielsen, Søren Saxmose, Olsen, John Elmerdahl, Toft, Nils, Zachariasen, Camilla   +7 more
core   +4 more sources

Time-programmable drug dosing allows the manipulation, suppression and reversal of antibiotic drug resistance in vitro [PDF]

, 2017
Multi-drug strategies have been attempted to prolong the efficacy of existing antibiotics, but with limited success. Here we show that the evolution of multi-drug-resistant Escherichia coli can be manipulated in vitro by administering pairs of ...
Cronin, Leroy, Furusawa, Chikara, Galiñanes Reyes, Sabrina Galiñanes, Horinouchi, Takaaki, Tsuda, Soichiro, Yoshida, Mari   +5 more
core   +1 more source

Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy. [PDF]

, 2019
Despite tremendous efforts to fight cancer, it remains a major public health problem and a leading cause of death worldwide. With increased knowledge of cancer pathways and improved technological platforms, precision therapeutics that specifically target
Bivona, Trever G, Chang, Samantha, Hernández, Amanda C, Keasling, Jay D, Kothari, Ankita, Mao, Jian-Hua, Snijders, Antoine M, Wang, Jessica, Zargar, Amin   +8 more
core   +1 more source

Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia [PDF]

BMC Urology, 2021
Abstract Background The urinary stone and urinary tract infection (UTI) are invariably associated and are frequent causes of morbidity. Date on burden of UTI among urinary stone patients is lacking in Ethiopia. This study was aimed to assess bacterial profile, antimicrobial susceptibility and associated factors among ...
Desie Kasew, Setegn Eshetie, Abeje Diress, Zerubabiel Tegegne, Feleke Moges   +4 more
openaire   +3 more sources

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

eLife, 2021
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat.
Claudia Igler, Jens Rolff, Roland Regoes
doaj   +1 more source