Results 21 to 30 of about 308,564 (306)

Multiple Drug Resistance Patterns in Various Phylogenetic Groups of Hospital-Acquired Uropathogenic E. coli Isolated from Cancer Patients

open access: yesAntibiotics, 2020
Cancer patients are more susceptible to several bacterial infections, particularly urinary tract infections caused by uropathogenic E. coli (UPEC).
A. Mahmoud   +4 more
semanticscholar   +1 more source

Role of bacterial efflux pumps in antibiotic resistance, virulence, and strategies to discover novel efflux pump inhibitors

open access: yesMicrobiology, 2023
The problem of antibiotic resistance among pathogenic bacteria has reached a crisis level. The treatment options against infections caused by multiple drug-resistant bacteria are shrinking gradually. The current pace of the discovery of new antibacterial
Amit Gaurav   +4 more
semanticscholar   +1 more source

Origin and Dynamics of Mycobacterium tuberculosis Subpopulations That Predictably Generate Drug Tolerance and Resistance

open access: yesmBio, 2022
Initial responses to tuberculosis treatment are poor predictors of final therapeutic outcomes in drug-susceptible disease, suggesting that treatment success depends on features that are hidden within a small minority of the overall infecting ...
Jees Sebastian   +8 more
doaj   +1 more source

Interplay in the selection of fluoroquinolone resistance and bacterial fitness. [PDF]

open access: yesPLoS Pathogens, 2009
Fluoroquinolones are antibacterial drugs that inhibit DNA Gyrase and Topoisomerase IV. These essential enzymes facilitate chromosome replication and RNA transcription by regulating chromosome supercoiling.
Linda L Marcusson   +2 more
doaj   +1 more source

Multi-step vs. single-step resistance evolution under different drugs, pharmacokinetics, and treatment regimens

open access: yeseLife, 2021
The success of antimicrobial treatment is threatened by the evolution of drug resistance. Population genetic models are an important tool in mitigating that threat.
Claudia Igler, Jens Rolff, Roland Regoes
doaj   +1 more source

Multiple drug resistance bacterial isolates and associated factors among urinary stone patients at the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia [PDF]

open access: yesBMC Urology, 2021
Abstract Background The urinary stone and urinary tract infection (UTI) are invariably associated and are frequent causes of morbidity. Date on burden of UTI among urinary stone patients is lacking in Ethiopia. This study was aimed to assess bacterial profile, antimicrobial susceptibility and associated factors among ...
Desie Kasew   +4 more
openaire   +3 more sources

Heavy metal tolerance and multiple drug resistance of heterotrophic bacterial isolates from metal contaminated soil [PDF]

open access: yesThe South Pacific Journal of Natural and Applied Sciences, 2013
The development of multiple metal/antibiotic resistances among the bacterial population causes a potential risk to human health. Metal contamination in natural environments could have an important role in the maintenance and proliferation of antibiotic resistance.
M. P. Krishna   +2 more
openaire   +1 more source

Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion

open access: yeseLife, 2019
Antibiotic resistance typically induces a fitness cost that shapes the fate of antibiotic-resistant bacterial populations. However, the cost of resistance can be mitigated by compensatory mutations elsewhere in the genome, and therefore the loss of ...
Anett Dunai   +12 more
semanticscholar   +1 more source

Thioredoxin Reductase Is a Valid Target for Antimicrobial Therapeutic Development Against Gram-Positive Bacteria

open access: yesFrontiers in Microbiology, 2021
There is a drought of new antibacterial compounds that exploit novel targets. Thioredoxin reductase (TrxR) from the Gram-positive bacterial antioxidant thioredoxin system has emerged from multiple screening efforts as a potential target for auranofin ...
LewisOscar Felix   +2 more
doaj   +1 more source

Human Multidrug-Resistant Salmonella Newport Infections, Wisconsin, 2003–2005

open access: yesEmerging Infectious Diseases, 2007
We conducted a retrospective study of Salmonella Newport infections among Wisconsin residents during 2003–2005. Multidrug resistance prevalence was substantially greater in Wisconsin than elsewhere in the United States.
Amy E. Karon   +4 more
doaj   +1 more source

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