Results 51 to 60 of about 308,564 (306)

Host-dependent Induction of Transient Antibiotic Resistance: A Prelude to Treatment Failure

EBioMedicine, 2015
Current antibiotic testing does not include the potential influence of host cell environment on microbial susceptibility and antibiotic resistance, hindering appropriate therapeutic intervention.
Jessica Z. Kubicek-Sutherland, Douglas M. Heithoff, Selvi C. Ersoy, William R. Shimp, John K. House, Jamey D. Marth, Jeffrey W. Smith, Michael J. Mahan   +7 more
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Multiple Mechanisms of the Synthesized Antimicrobial Peptide TS against Gram-Negative Bacteria for High Efficacy Antibacterial Action In Vivo

Molecules, 2020
The emergence of drug-resistant bacteria emphasizes the urgent need for novel antibiotics. The antimicrobial peptide TS shows extensive antibacterial activity in vitro and in vivo, especially in gram-negative bacteria; however, its antibacterial ...
Rui Zhang, Xiaobo Fan, Xinglu Jiang, Mingyuan Zou, Han Xiao, Guoqiu Wu   +5 more
doaj   +1 more source

A Prediction Method for Animal-Derived Drug Resistance Trend Using a Grey-BP Neural Network Combination Model

Antibiotics, 2021
There is an increasing drug resistance of animal-derived pathogens, seriously posing a huge threat to the health of animals and humans. Traditional drug resistance testing methods are expensive, have low efficiency, and are time-consuming, making it ...
Xinxing Li, Ziyi Zhang, Ding Xu, Congming Wu, Jianping Li, Yongjun Zheng   +5 more
doaj   +1 more source

Isolation and Identification of Multiple Drug Resistant Bacterial Pathogens from Well Water Samples in and Around Wolaita Sodo Town, Southern Ethiopia

Journal of Drug Delivery and Therapeutics, 2021
Water for human consumption is required to be free from any bacteria that might pose a health risk. The worldwide prevalence of pathogen contamination is a serious concern, and enhancing the understanding of major pathogen sources and their significant impacts on water resources is crucial. Further, these organisms underwent multiple drug resistance in
Subramaniyan Vaithilingam, Krishna Moorthy Sivalingam   +1 more
openaire   +2 more sources

Inhibiting Bacterial Drug Efflux Pumps via Phyto-Therapeutics to Combat Threatening Antimicrobial Resistance

Frontiers in Microbiology, 2018
Antibiotics, once considered the lifeline for treating bacterial infections, are under threat due to the emergence of threatening antimicrobial resistance (AMR). These drug-resistant microbes (or superbugs) are non-responsive to most of the commonly used
V. Shriram, T. Khare, R. Bhagwat, R. Shukla, Vinay Kumar   +4 more
semanticscholar   +1 more source

Decoy Nanozymes Enable Multitarget Blockade of Proinflammatory Cascades for the Treatment of Multi-Drug-Resistant Bacterial Sepsis

Research, 2022
Sepsis is a life-threatening organ dysfunction characterized by severe systemic inflammatory response to infection. Effective treatment of bacterial sepsis remains a paramount clinical challenge, due to its astonishingly rapid progression and the ...
Xuancheng Du, Mingzhen Zhang, Huiting Zhou, Weijie Wang, Chengmei Zhang, Lei Zhang, Yuanyuan Qu, Weifeng Li, Xiangdong Liu, Ming-cai Zhao, K. Tu, Yongqiang Li   +11 more
semanticscholar   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

The Utility of Colistin in Multiple Drug-Resistant Pseudomonas aeruginosa Bacterial Keratitis in a Kaposi’s Sarcoma Patient

Turkish journal of ophthalmology, 2019
WOS ...
Barut Selver Ö., Eğrilmez S., Hasanov S., Yılmaz Dağ M., Tunger A.   +4 more
openaire   +5 more sources

Enabling genomic island prediction and comparison in multiple genomes to investigate bacterial evolution and outbreaks

Microbial Genomics, 2022
Outbreaks of virulent and/or drug-resistant bacteria have a significant impact on human health and major economic consequences. Genomic islands (GIs; defined as clusters of genes of probable horizontal origin) are of high interest because they ...
C. Bertelli, Kristen L. Gray, Nolan Woods, A. C. Lim, Keith E. Tilley, G. Winsor, Gemma Hoad, A. Roudgar, Adam Spencer, James Peltier, Derek Warren, A. Raphenya, A. McArthur, F. Brinkman   +13 more
semanticscholar   +1 more source