Results 161 to 170 of about 1,436,718 (300)

The time is now: making the case for compassionate use/pre-approval access to new TB drugs. [PDF]

IJTLD Open
Reuter A, Stillo J, Thi SS, Motta I, Migliori GB, Mesic A, Mbenga M, Howell P, Guglielmetti L, Gebhard A, DeCroo T, D'Ambrosio L, Furin J.   +12 more
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

PYK2/FAK inhibitors reverse hypoxia-induced drug resistance in multiple myeloma

Haematologica, 2019
Barbara Muz, Maurizio Buggio, Feda Azab, Pilar de la Puente, Mark Fiala, Mahesh V. Padval, David T. Weaver, Jonathan A. Pachter, Ravi Vij, Abdel Kareem Azab   +9 more
doaj   +1 more source

Mechanistic and translational insights into plant-derived natural products in preclinical multiple myeloma research: Current evidence. [PDF]

Transl Oncol
Li L, Xu J, Yu L, Shi J, Li C, Gu J, Wang Y, Cui S.   +7 more
europepmc   +1 more source

Tumor‐stromal crosstalk and macrophage enrichment are associated with chemotherapy response in bladder cancer

FEBS Open Bio, EarlyView.
Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold, Janik Riese, Lancelot Seillier, Mark Kühnel, Julia Pannhausen, Charlotte O. J. Fröhlich, Christian Martin, Peter Boor, Matthias Saar, Danny D. Jonigk, Nadine T. Gaisa, Michael Rose   +11 more
wiley   +1 more source

Proteomic Characterization Reveals CYP2S1 as a Mediator of Drug Resistance in PDAC. [PDF]

Pancreas
Thiel V, Nadler WM, Kerner A, Kuhlmann L, Reitberger M, Vorberg T, Schwerd-Kleine P, Noll E, Giese NA, Yen HY, Steiger K, Vogel V, Klein C, Hackert T, Koschny R, Opitz CA, Trumpp A, Sprick MR, Rösli C.   +18 more
europepmc   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Drug resistance profile of <i>Mycobacterium tuberculosis</i> in China: update until 2024. [PDF]

Front Microbiol
Xu Y, Liu S, Zheng J, Lin J, Gi L, Chang Q.   +5 more
europepmc   +1 more source

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

Targeting ferroptosis to overcome drug resistance in lung cancer. [PDF]

Transl Lung Cancer Res
Sheng P, Jin J, Liu H, Sun C, Chen Y, Chen X, Ma D, Shen J.   +7 more
europepmc   +1 more source