Results 231 to 240 of about 2,071,500 (370)

Identifying prognostic targets in metastatic prostate cancer beyond AR

FEBS Open Bio, EarlyView.
Genome‐wide functional screens combined with a large gene expression database and clinical outcomes can identify new therapeutic vulnerabilities in prostate cancer. Eight potentially druggable targets demonstrated strong dependency in cell lines, were associated with worse prognosis clinically, and showed evidence of protein expression in prostate ...
Emily Feng, Eric Feng, Tracy Berg, Isabella S. Nguyen, Lilac G. Nguyen, William Chen, Meng Zhang, David Quigley, Marina Sharifi, Haolong Li, Ilsa Coleman, Peter S. Nelson, Martin Sjöström, Shuang G. Zhao   +13 more
wiley   +1 more source

Role of M2 macrophage-derived exosomes in cancer drug resistance via noncoding RNAs. [PDF]

Discov Oncol
Hu X, Li Y, Wang X, Xue X.
europepmc   +1 more source

Multiple antimicrobial drug resistance in enteric pathogens [PDF]

Journal of Antimicrobial Chemotherapy, 1981
B. Rowe, E.J. Threlfall
openaire   +3 more sources

Understanding and Overcoming Immunotherapy Resistance in Skin Cancer: Mechanisms and Strategies

Aging and Cancer, EarlyView.
This narrative review explores the mechanisms driving immunotherapy resistance in skin cancer, including tumor microenvironment factors, genetic mutations, and immune evasion strategies. It highlights potential strategies to overcome resistance, offering insights for improving therapeutic outcomes and guiding future research in personalized ...
Shreya Singh Beniwal, Abhimanyu Chiraparambil Radhakrishnan, Ayanchetty Haripraba, Saif Syed, Gajawada Pragna, Ayush Dwivedi, Akash Rawat, Daniela Castro Calderón, Martin Cevallos‐Cueva   +8 more
wiley   +1 more source

P-Glycoprotein as a Therapeutic Target in Hematological Malignancies: A Challenge to Overcome. [PDF]

Int J Mol Sci
Álvarez-Carrasco P, Morales-Villamil F, Maldonado-Bernal C.   +2 more
europepmc   +1 more source

Origin and Proliferation of Multiple-Drug Resistance in Bacterial Pathogens

Microbiology and Molecular Reviews, 2015
Hsiao-Han Chang, T. Cohen, Y. Grad, W. Hanage, T. O'Brien, M. Lipsitch   +5 more
semanticscholar   +1 more source

The neglected model validation of antimicrobial resistance transmission models - a systematic review. [PDF]

Antimicrob Resist Infect Control
Brinch ML, Palladino A, Geurtsen J, Van Effelterre T, Argante L, McConnell MJ, Christiansen L, Pihl MA, Lund NK, Hald T.   +9 more
europepmc   +1 more source

Impact of enhanced leaf model on dose calculation accuracy in single‐isocenter multitarget stereotactic radiosurgery treatments

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Purpose Single‐isocenter multitarget (SIMT) radiosurgery has become increasingly popular as advancement in planning and delivery systems have made this approach clinically viable. With targets varying in size and distance from isocenter, SIMT plans are highly complex with dynamic multileaf collimator (MLC) motion.
Hem Moktan, Hongyu Jiang, H. Harold Li, Kenny Guida   +3 more
wiley   +1 more source

A thematic analysis of prognostic, diagnostic, and therapeutic of circulating miRNA biomarkers in bortezomib-resistant multiple myeloma. [PDF]

SAGE Open Med
Bamfield-Cummings S, Silva J, Karim ZA.
europepmc   +1 more source

Toward a human‐centric co‐design methodology for AI detection of differences between planned and delivered dose in radiotherapy

Journal of Applied Clinical Medical Physics, EarlyView.
Abstract Introduction Many artificial intelligence (AI) solutions have been proposed to enhance the radiotherapy (RT) workflow, but limited applications have been implemented to date, suggesting an implementation gap. One contributing factor to this gap is a misalignment between AI systems and their users.
Luca M. Heising, Frank Verhaegen, Stefan G. Scheib, Maria J. G. Jacobs, Carol X. J. Ou, Viola Mottarella, Yin‐Ho Chong, Mariangela Zamburlini, Sebastiaan M. J. J. G. Nijsten, Ans Swinnen, Michel Öllers, Cecile J. A. Wolfs   +11 more
wiley   +1 more source