Results 321 to 330 of about 2,071,500 (370)

Drug resistance and drug development in multiple myeloma

Seminars in Oncology, 2002
Circumvention of drug resistance in multiple myeloma is a major obstacle to improving clinical outcomes for myeloma patients. Identification of several mechanisms of acquired drug resistance has led to the development of chemosensitizing agents that counter specific drug resistance mechanisms.
openaire   +3 more sources

Topoisomerase I in multiple drug resistance

Cytotechnology, 1993
Topoisomerase I is a nuclear enzyme able to catalyse the relaxation of supercoiled DNA by introducing single-stranded breaks in DNA molecule. Its function seems important to prepare DNA for many processes such as recombination, DNA repair and RNA transcription.
openaire   +3 more sources

Multiple or pleiotropic drug resistance in yeast

Biochimica et Biophysica Acta (BBA) - General Subjects, 1991
The purpose of this review is to gather genetic and biochemical data established on multiple drug resistance in yeast, with a view to the implications that these findings may have for unravelling the mechanism of multidrug resistance in higher ...
Elisabetta Balzi, André Goffeau
openaire   +3 more sources

Molecular cytogenetics of multiple drug resistance

Cytotechnology, 1993
The refractory nature of many human cancers to multi-agent chemotherapy is termed multidrug resistance (MDR). In the past several decades, a major focus of clinical and basic research has been to characterize the genetic and biochemical mechanisms mediating this phenomenon.
openaire   +3 more sources

Self-assembled polymer/inorganic hybrid nanovesicles for multiple drug delivery to overcome drug resistance in cancer chemotherapy.

Langmuir, 2015
With the aim to develop a facile strategy to prepare functional drug carriers to overcome multidrug resistance (MDR), we prepared heparin/protamine/calcium carbonate (HP/PS/CaCO3) hybrid nanovesicles with enhanced cell internalization, good serum ...
Meng-Qing Gong, Jin-Long Wu, Bin Chen, R. Zhuo, Si-Xue Cheng   +4 more
semanticscholar   +1 more source

Drug resistance in multiple myeloma.

Seminars in hematology, 1997
The development of multidrug resistance (MDR) is a major obstacle to improving treatment outcomes in multiple myeloma. Recent studies have indicated that several specific mechanisms of MDR may be involved in clinically refractory multiple myeloma patients, such as expression of P-glycoprotein (P-gp), expression of the lung-resistance protein (LRP) and ...
Sonneveld, Pieter, Lokhorst, HM, Vossebelt, PJM   +2 more
openaire   +2 more sources

Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells.

Blood, 2014
The interplay between bone marrow stromal cells (BMSCs) and multiple myeloma (MM) cells performs a crucial role in MM pathogenesis by secreting growth factors, cytokines, and extracellular vesicles.
Jinheng Wang, A. Hendrix, S. Hernot, M. Lemaire, E. De Bruyne, E. Van Valckenborgh, T. Lahoutte, O. De Wever, K. Vanderkerken, E. Menu   +9 more
semanticscholar   +1 more source

In vitro models of multiple drug resistance

1994
The emergence of drug resistance in many ways reflects evolution; those cells capable of surviving exposure to an environmental stress propagate. This is particularly important in cancer, where it has been estimated that 90% of the 500,000 annual cancer fatalities in the United States are influenced by drug resistance [1].
Susan Band Horwitz, Dalia Cohen, Lee M. Greenberger   +2 more
openaire   +3 more sources

Transmissible Drug-resistance Factors and Formation of Multiple Resistance

Nature, 1962
IN earlier reports several types of drug (chloramphenicol, Cm; tetracycline, Tc; streptomycin, Sm; sulphanilamide, Da) resistant Escherichia coli and Shigella were described1–3. It was also found that seven types of drug resistance are transmitted by cell-to-cell contact4.
S. Mitsuhashi, Kenji Harada
openaire   +3 more sources

Multiple Drug Resistance Mechanisms in Cancer

Molecular Biotechnology, 2010
Multiple drug resistance (multidrug resistance; MDR), a phenomenon whereby human tumours that acquire resistance to one type of therapy are found to be resistant to several other drugs that are often quite different in both structure and mode of action, has been recognised clinically for several decades. An important advance in our understanding of MDR
openaire   +3 more sources