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Drug resistance in multiple myeloma.
Pathologie-biologie, 1999Multidrug resistance (MDR) is a pleiotropic resistance against several unrelated drugs. It may be induced by prolonged exposure of cells to drugs such as doxorubicin, etoposide and vinca alkaloids. Once MDR develops in clinical tumors, it is a major obstacle for the improvement of treatment of multiple myeloma (MM).
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Multiple drug resistance in the pathogenic protozoa
Acta Tropica, 1994Evidence for the phenomenon of multiple drug resistance (MDR) in the well studied pathogenic protozoa has been examined. This has been placed in the more familiar context of the MDR efflux transporters and the cloned mdr genes of mammalian cells. Homologues of the mdr gene family in protozoa and their possible role in drug efflux have been compared ...
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Management of Multiple Drug-Resistant Malaria
2004Each year, malaria accounts for more deaths worldwide than any other parasitic disease, with mortality estimates of between 1.5 and 2.7 million (1). Malaria not only is associated with huge morbidity and mortality, but also it hampers economic growth, trapping endemic countries in a cycle of poverty and disease (2–4).The main disease burden is in ...
François Nosten, Elizabeth A. Ashley
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Infectious Multiple Drug Resistance in the Enterobacteriaceae
1975Abstract : The antibiotic resistance gene of R plasmids which encodes for ampicillin resistance resides upon a 3.7 x 3700000 dalton sequence of DNA, TnA, which can migrate (translocate) from plasmid to plasmid. The translocation of TnA occurs independently of normal bacterial rec functions so that it permits rearrangement and recombination of DNA ...
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Cellular models for multiple drug resistance in cancer
In Vitro Cellular & Developmental Biology - Animal, 1993Considerable progress has been made toward understanding some of the molecular mechanisms underlying MDR in cancer cells in vitro, and sensitive techniques such as immunocytochemistry and RT-PCR indicate that these mechanisms may also play a role in resistance in human cancers.
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MULTIPLE-DRUG-RESISTANT TUBERCULOSIS
The Pediatric Infectious Disease Journal, 1995Heinz F. Eichenwald, R. F. Jacobs
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