Results 1 to 10 of about 283,019 (191)

Kinome rewiring during acquired drug resistance in neuroendocrine neoplasms [PDF]

Endocrine-Related Cancer, 2021
Although there is evidence of a significant rise of neuroendocrine neoplasms (NENs) incidence, current treatments are largely insufficient due to somewhat poor knowledge of these tumours. Despite showing differentiated features, NENs exhibit therapeutic resistance to most common treatments, similar to other cancers in many instances.
Gerard, Corinne, Lagarde, Marie, Poizat, Flora, Oziel-Taieb, Sandrine, Garcia, Vincent, Roche, Catherine, Niccoli, Patricia, Barlier, Anne, Romano, David   +8 more
openaire   +3 more sources

Multi-Drug Resistance against Second-Line Medication and MicroRNA Plasma Level in Metastatic Breast Cancer Patients [PDF]

Iranian Journal of Medical Sciences, 2023
Background: Circulating microRNAs (miRNAs) can help to predict the chemotherapy response in breast cancer with promising results. The aim of the present study was to investigate the relationships between the miR-199a, miR-663a, and miR-663b expression ...
Mehdi Dehghani, Samira Mokhtari, Hassan Abidi, Behnam Alipoor, Mohammad Amin Nazer Mozaffari, Hossein Sadeghi, Reza Mahmoudi, Mohsen Nikseresht   +7 more
doaj   +1 more source

Systematic Investigation of DNA Methylation Associated With Platinum Chemotherapy Resistance Across 13 Cancer Types

Frontiers in Pharmacology, 2021
Background: Platinum resistance poses a significant problem for oncology clinicians. As a result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers in recent years. A systematic
Ruizheng Sun, Ruizheng Sun, Chao Du, Chao Du, Jiaxin Li, Jiaxin Li, Yanhong Zhou, Yanhong Zhou, Wei Xiong, Wei Xiong, Juanjuan Xiang, Juanjuan Xiang, Jiheng Liu, Zhigang Xiao, Li Fang, Zheng Li, Zheng Li   +16 more
doaj   +1 more source

The study of FGFR3 ⁃ TACC3 fusion gene mediating pyruvate kinase M2 nuclear translocation to promote DNA damage repair in glioblastoma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Objective To explore the mechanism of FGFR3⁃TACC3 (F3⁃T3) fusion gene mediating DNA damage repair through promoting pyruvate kinase M2 (PKM2)'s nuclear translocation in glioblastoma.
REN Xiu⁃de, LI Tao, FAN Ji⁃kang, WANG Xi⁃sen, JIA Xiao⁃dan, YANG Xue⁃jun   +5 more
doaj   +1 more source

The effect of resistancerelated proteins on the prognosis and survival of patients with osteosarcoma: an immunohistochemical analysis

Acta Orthopaedica et Traumatologica Turcica, 2020
Objectives: Despite the developments in chemotherapy protocols, improvement in the survival rates of osteosarcoma has been limited. We evaluated the effect of certain prognosis-related proteins on survival of patients with osteosarcoma.\r\nMethods: Data ...
Harzem Ozger, Levent Eralp, Ata Can lar, Berkin Toker, Lora Esberk Ates, Mustafa Sungur, Bilge Bilgic, Inci Ayan   +7 more
doaj   +1 more source

Molecular and Clinical Data of Antimicrobial Resistance in Microorganisms Producing Bacteremia in a Multicentric Cohort of Patients with Cancer in a Latin American Country

Microorganisms, 2023
Patients with cancer have a higher risk of severe bacterial infections. This study aims to determine the frequency, susceptibility profiles, and resistance genes of bacterial species involved in bacteremia, as well as risk factors associated with ...
Sergio Andrés Cruz-Vargas, Laura García-Muñoz, Sonia Isabel Cuervo-Maldonado, Carlos Arturo Álvarez-Moreno, Carlos Humberto Saavedra-Trujillo, José Camilo Álvarez-Rodríguez, Angélica Arango-Gutiérrez, Julio César Gómez-Rincón, Katherine García-Guzman, Aura Lucía Leal, Javier Garzón-Herazo, Samuel Martínez-Vernaza, Fredy Orlando Guevara, Leydy Paola Jiménez-Cetina, Liliana Marcela Mora, Sandra Yamile Saavedra, Jorge Alberto Cortés   +16 more
doaj   +1 more source

Targeting Cell-Impermeable Prodrug Activation to Tumor Microenvironment Eradicates Multiple Drug-Resistant Neoplasms [PDF]

Cancer Research, 2006
AbstractThe tumor microenvironment is notably enriched with a broad spectrum of proteases. The proteolytic specificities of peptide substrates provide modular chemical tools for the rational design of cell-impermeable prodrugs that are specifically activated by proteases extracellularly in the tumor microenvironment.
Wenyuan, Wu, Yunping, Luo, Chengzao, Sun, Yuan, Liu, Paul, Kuo, Janos, Varga, Rong, Xiang, Ralph, Reisfeld, Kim D, Janda, Thomas S, Edgington, Cheng, Liu   +10 more
openaire   +2 more sources

A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer

Molecular Cancer, 2023
Aim Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was investigated using in silico, in vitro, and in vivo approaches.
Sandra Kendzia, Susanne Franke, Tarek Kröhler, Nicole Golob-Schwarzl, Caroline Schweiger, Anna M. Toeglhofer, Christina Skofler, Stefan Uranitsch, Amin El-Heliebi, Julia Fuchs, Andreas Punschart, Philipp Stiegler, Marlen Keil, Jens Hoffmann, David Henderson, Hans Lehrach, Marie-Laure Yaspo, Christoph Reinhard, Reinhold Schäfer, Ulrich Keilholz, Christian Regenbrecht, Rudolf Schicho, Peter Fickert, Sigurd F. Lax, Frank Erdmann, Marcel H. Schulz, Alexandra K. Kiemer, Johannes Haybaeck, Sonja M. Kessler   +28 more
doaj   +1 more source

Cervical cancer heterogeneity: a constant battle against viruses and drugs

Biomarker Research, 2022
Cervical cancer is the first identified human papillomavirus (HPV) associated cancer and the most promising malignancy to be eliminated. However, the ever-changing virus subtypes and acquired multiple drug resistance continue to induce failure of tumor ...
Qian Sun, Liangliang Wang, Cong Zhang, Zhenya Hong, Zhiqiang Han   +4 more
doaj   +1 more source

Synthesis and Antitumor Activity of a GSH Inert Bisphosphonate Platinum (II) Complex

Journal of Chemistry, 2022
Osteosarcoma is a highly aggressive neoplasm. Traditional platinum chemotherapeutic agents for osteosarcoma inevitably have acquired drug resistance and serious side effects, which have limited their utility.
Lu Ma, Hua Liu, Yichun Ju, Kai Chen, Yi Yang, Zhichao Zhou, Zhenqin Zhang, Zheng Cai   +7 more
doaj   +1 more source