Results 11 to 20 of about 640,629 (321)

Systematic Investigation of DNA Methylation Associated With Platinum Chemotherapy Resistance Across 13 Cancer Types

Frontiers in Pharmacology, 2021
Background: Platinum resistance poses a significant problem for oncology clinicians. As a result, the role of epigenetics and DNA methylation in platinum-based chemoresistance has gained increasing attention from researchers in recent years. A systematic
Ruizheng Sun, Ruizheng Sun, Chao Du, Chao Du, Jiaxin Li, Jiaxin Li, Yanhong Zhou, Yanhong Zhou, Wei Xiong, Wei Xiong, Juanjuan Xiang, Juanjuan Xiang, Jiheng Liu, Zhigang Xiao, Li Fang, Zheng Li, Zheng Li   +16 more
doaj   +1 more source

The study of FGFR3 ⁃ TACC3 fusion gene mediating pyruvate kinase M2 nuclear translocation to promote DNA damage repair in glioblastoma

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
Objective To explore the mechanism of FGFR3⁃TACC3 (F3⁃T3) fusion gene mediating DNA damage repair through promoting pyruvate kinase M2 (PKM2)'s nuclear translocation in glioblastoma.
REN Xiu⁃de, LI Tao, FAN Ji⁃kang, WANG Xi⁃sen, JIA Xiao⁃dan, YANG Xue⁃jun   +5 more
doaj   +1 more source

Drug Resistance in Osteosarcoma: Emerging Biomarkers, Therapeutic Targets and Treatment Strategies

Cancers, 2021
Simple Summary Despite the adoption of aggressive, multimodal treatment schedules, the cure rate of high-grade osteosarcoma (HGOS) has not significantly improved in the last 30 years.
C. Hattinger, Maria Pia Patrizio, Leonardo Fantoni, Chiara Casotti, C. Riganti, M. Serra   +5 more
semanticscholar   +1 more source

Emerging Therapeutic Strategies to Overcome Drug Resistance in Multiple Myeloma

Cancers, 2021
Simple Summary Multiple myeloma is a deadly blood cancer, but fortunately drug development has substantially prolonged the lifespan of patients to average more than a decade after diagnosis with optimal therapy.
Lorraine N Davis, Daniel W. Sherbenou
semanticscholar   +1 more source

Molecular and Clinical Data of Antimicrobial Resistance in Microorganisms Producing Bacteremia in a Multicentric Cohort of Patients with Cancer in a Latin American Country

Microorganisms, 2023
Patients with cancer have a higher risk of severe bacterial infections. This study aims to determine the frequency, susceptibility profiles, and resistance genes of bacterial species involved in bacteremia, as well as risk factors associated with ...
Sergio Andrés Cruz-Vargas, Laura García-Muñoz, Sonia Isabel Cuervo-Maldonado, Carlos Arturo Álvarez-Moreno, Carlos Humberto Saavedra-Trujillo, José Camilo Álvarez-Rodríguez, Angélica Arango-Gutiérrez, Julio César Gómez-Rincón, Katherine García-Guzman, Aura Lucía Leal, Javier Garzón-Herazo, Samuel Martínez-Vernaza, Fredy Orlando Guevara, Leydy Paola Jiménez-Cetina, Liliana Marcela Mora, Sandra Yamile Saavedra, Jorge Alberto Cortés   +16 more
doaj   +1 more source

Targeting Cell-Impermeable Prodrug Activation to Tumor Microenvironment Eradicates Multiple Drug-Resistant Neoplasms [PDF]

Cancer Research, 2006
AbstractThe tumor microenvironment is notably enriched with a broad spectrum of proteases. The proteolytic specificities of peptide substrates provide modular chemical tools for the rational design of cell-impermeable prodrugs that are specifically activated by proteases extracellularly in the tumor microenvironment.
Wenyuan, Wu, Yunping, Luo, Chengzao, Sun, Yuan, Liu, Paul, Kuo, Janos, Varga, Rong, Xiang, Ralph, Reisfeld, Kim D, Janda, Thomas S, Edgington, Cheng, Liu   +10 more
openaire   +2 more sources

A combined computational and functional approach identifies IGF2BP2 as a driver of chemoresistance in a wide array of pre-clinical models of colorectal cancer

Molecular Cancer, 2023
Aim Chemoresistance is a major cause of treatment failure in colorectal cancer (CRC) therapy. In this study, the impact of the IGF2BP family of RNA-binding proteins on CRC chemoresistance was investigated using in silico, in vitro, and in vivo approaches.
Sandra Kendzia, Susanne Franke, Tarek Kröhler, Nicole Golob-Schwarzl, Caroline Schweiger, Anna M. Toeglhofer, Christina Skofler, Stefan Uranitsch, Amin El-Heliebi, Julia Fuchs, Andreas Punschart, Philipp Stiegler, Marlen Keil, Jens Hoffmann, David Henderson, Hans Lehrach, Marie-Laure Yaspo, Christoph Reinhard, Reinhold Schäfer, Ulrich Keilholz, Christian Regenbrecht, Rudolf Schicho, Peter Fickert, Sigurd F. Lax, Frank Erdmann, Marcel H. Schulz, Alexandra K. Kiemer, Johannes Haybaeck, Sonja M. Kessler   +28 more
doaj   +1 more source

Cervical cancer heterogeneity: a constant battle against viruses and drugs

Biomarker Research, 2022
Cervical cancer is the first identified human papillomavirus (HPV) associated cancer and the most promising malignancy to be eliminated. However, the ever-changing virus subtypes and acquired multiple drug resistance continue to induce failure of tumor ...
Qian Sun, Liangliang Wang, Cong Zhang, Zhenya Hong, Zhiqiang Han   +4 more
doaj   +1 more source

Synthesis and Antitumor Activity of a GSH Inert Bisphosphonate Platinum (II) Complex

Journal of Chemistry, 2022
Osteosarcoma is a highly aggressive neoplasm. Traditional platinum chemotherapeutic agents for osteosarcoma inevitably have acquired drug resistance and serious side effects, which have limited their utility.
Lu Ma, Hua Liu, Yichun Ju, Kai Chen, Yi Yang, Zhichao Zhou, Zhenqin Zhang, Zheng Cai   +7 more
doaj   +1 more source

In silico drug repurposing and lipid bilayer molecular dynamics puzzled out potential breast cancer resistance protein (BCRP/ABCG2) inhibitors

Journal of Biomolecular Structure and Dynamics, 2022
Multidrug resistance (MDR) is a fundamental reason for the fiasco of carcinoma chemotherapy. A wide variety of anticarcinoma drugs are expelled from neoplasm cells through the ATP-binding cassette (ABC) transporter superfamily, rendering the neoplasm ...
N. Almansour, Alaa H. M. Abdelrahman, Ekram Ismail Fagiree, Mahmoud A. A. Ibrahim   +3 more
semanticscholar   +1 more source